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KCNJ10 potassium inwardly rectifying channel subfamily J member 10 [ Canis lupus familiaris (dog) ]

Gene ID: 488635, updated on 17-Aug-2024

Summary

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Official Symbol
KCNJ10provided by VGNC
Official Full Name
potassium inwardly rectifying channel subfamily J member 10provided by VGNC
Primary source
VGNC:VGNC:110595
See related
Ensembl:ENSCAFG00845030876
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See KCNJ10 in Genome Data Viewer
Location:
chromosome: 38
Exon count:
3
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 38 NC_051842.1 (22234321..22263231)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 38 NC_006620.4 (22189839..22218736)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 38 NC_049259.1 (22944114..22972999)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 38 NC_049298.1 (22138483..22167351)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 38 NC_049779.1 (22534821..22563698)

Chromosome 38 - NC_051842.1Genomic Context describing neighboring genes Neighboring gene immunoglobulin superfamily member 8 Neighboring gene uncharacterized LOC111094550 Neighboring gene potassium inwardly rectifying channel subfamily J member 9 Neighboring gene phosphatidylinositol glycan anchor biosynthesis class M Neighboring gene SLAM family member 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A Missense Variant in KCNJ10 in Belgian Shepherd Dogs Affected by Spongy Degeneration with Cerebellar Ataxia (SDCA1). Mauri N, et al. G3 (Bethesda), 2017 Feb 9. PMID 28007838, Free PMC Article
  2. The novel homozygous KCNJ10 c.986T>C (p.(Leu329Pro)) variant is pathogenic for the SeSAME/EAST homologue in Malinois dogs. Van Poucke M, et al. Eur J Hum Genet, 2017 Feb. PMID 27966545, Free PMC Article
  3. A KCNJ10 mutation previously identified in the Russell group of terriers also occurs in Smooth-Haired Fox Terriers with hereditary ataxia and in related breeds. Rohdin C, et al. Acta Vet Scand, 2015 May 23. PMID 25998802, Free PMC Article
  4. Regulation of Kir4.1 and AQP4 expression and stability at the basolateral domain of epithelial MDCK cells by the extracellular matrix. Tham DK, et al. Am J Physiol Renal Physiol, 2011 Aug. PMID 21543416, Free PMC Article
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. we consider KCNJ10:c.986T>C the most likely candidate causative variant for one subtype of SDCA in Malinois dogs, which we propose to term spongy degeneration with cerebellar ataxia 1 (SDCA1).
    Title: A Missense Variant in KCNJ10 in Belgian Shepherd Dogs Affected by Spongy Degeneration with Cerebellar Ataxia (SDCA1).
  2. A novel pathogenic KCNJ10 c.986T>C (p.(Leu329Pro)) variant identified in dogs with SeSAME/EAST syndrome.
    Title: The novel homozygous KCNJ10 c.986T>C (p.(Leu329Pro)) variant is pathogenic for the SeSAME/EAST homologue in Malinois dogs.
  3. A KCNJ10 mutation, previously associated with an autosomal recessive spinocerebellar ataxia in Jack Russell Terriers, Parson Russell Terriers, and Russell Terriers segregates in at least three more breeds descended from British hunting terriers.
    Title: A KCNJ10 mutation previously identified in the Russell group of terriers also occurs in Smooth-Haired Fox Terriers with hereditary ataxia and in related breeds.
  4. interaction of dystroglycan and integrins with the extracellular matrix plays an important role in the polarized distribution of Kir4.1 and AQP4 at the basolateral domain of kidney epithelial cells
    Title: Regulation of Kir4.1 and AQP4 expression and stability at the basolateral domain of epithelial MDCK cells by the extracellular matrix.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables inward rectifier potassium channel activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in potassium ion import across plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
ATP-sensitive inward rectifier potassium channel 10
Names
potassium channel inwardly rectifying subfamily J member 10
potassium voltage-gated channel subfamily J member 10

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051842.1 Reference ROS_Cfam_1.0

    Range
    22234321..22263231
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038448704.1 → XP_038304632.1  ATP-sensitive inward rectifier potassium channel 10 isoform X1

    UniProtKB/TrEMBL
    A0A8C0NBG7, A0A8C0SYI0, A0A8I3Q5M6
    Related
    ENSCAFP00845043159.1, ENSCAFT00845054881.1
    Conserved Domains (2) summary
    pfam01007
    Location:66 → 207
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:214 → 389
    IRK_C; Inward rectifier potassium channel C-terminal domain

  2. XM_038448705.1 → XP_038304633.1  ATP-sensitive inward rectifier potassium channel 10 isoform X2

    UniProtKB/TrEMBL
    A0A1P8VFW1, A0A8C0NBG7
    Conserved Domains (2) summary
    pfam01007
    Location:31 → 172
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:179 → 354
    IRK_C; Inward rectifier potassium channel C-terminal domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049298.1 Alternate UMICH_Zoey_3.1

    Range
    22138483..22167351
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038522585.1 → XP_038378513.1  ATP-sensitive inward rectifier potassium channel 10 isoform X1

    Conserved Domains (2) summary
    pfam01007
    Location:66 → 207
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:214 → 389
    IRK_C; Inward rectifier potassium channel C-terminal domain

  2. XM_038522586.1 → XP_038378514.1  ATP-sensitive inward rectifier potassium channel 10 isoform X2

    Conserved Domains (2) summary
    pfam01007
    Location:31 → 172
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:179 → 354
    IRK_C; Inward rectifier potassium channel C-terminal domain

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049779.1 Alternate UNSW_CanFamBas_1.0

    Range
    22534821..22563698
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038650792.1 → XP_038506720.1  ATP-sensitive inward rectifier potassium channel 10 isoform X1

    Conserved Domains (2) summary
    pfam01007
    Location:66 → 207
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:214 → 389
    IRK_C; Inward rectifier potassium channel C-terminal domain

  2. XM_038650793.1 → XP_038506721.1  ATP-sensitive inward rectifier potassium channel 10 isoform X2

    Conserved Domains (2) summary
    pfam01007
    Location:31 → 172
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:179 → 354
    IRK_C; Inward rectifier potassium channel C-terminal domain

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049259.1 Alternate UU_Cfam_GSD_1.0

    Range
    22944114..22972999
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038586373.1 → XP_038442301.1  ATP-sensitive inward rectifier potassium channel 10 isoform X1

    UniProtKB/TrEMBL
    A0A8C0NBG7, A0A8C0SYI0, A0A8I3Q5M6
    Conserved Domains (2) summary
    pfam01007
    Location:66 → 207
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:214 → 389
    IRK_C; Inward rectifier potassium channel C-terminal domain

  2. XM_038586374.1 → XP_038442302.1  ATP-sensitive inward rectifier potassium channel 10 isoform X2

    UniProtKB/TrEMBL
    A0A1P8VFW1, A0A8C0NBG7
    Conserved Domains (2) summary
    pfam01007
    Location:31 → 172
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:179 → 354
    IRK_C; Inward rectifier potassium channel C-terminal domain

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006620.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    22189839..22218736
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005640901.4 → XP_005640958.1  ATP-sensitive inward rectifier potassium channel 10 isoform X1

    UniProtKB/TrEMBL
    A0A8C0NBG7, A0A8C0SYI0, A0A8I3Q5M6
    Conserved Domains (2) summary
    pfam01007
    Location:66 → 207
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:214 → 389
    IRK_C; Inward rectifier potassium channel C-terminal domain

  2. XM_545752.7 → XP_545752.3  ATP-sensitive inward rectifier potassium channel 10 isoform X2

    UniProtKB/TrEMBL
    A0A1P8VFW1, A0A8C0NBG7
    Conserved Domains (2) summary
    pfam01007
    Location:31 → 172
    IRK; Inward rectifier potassium channel
    pfam17655
    Location:179 → 354
    IRK_C; Inward rectifier potassium channel C-terminal domain
Nucleotide Protein Strain
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