U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CLN8 CLN8 transmembrane ER and ERGIC protein [ Canis lupus familiaris (dog) ]

Gene ID: 488558, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Gene symbol
CLN8
Gene description
CLN8 transmembrane ER and ERGIC protein
See related
Ensembl:ENSCAFG00845019093
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See CLN8 in Genome Data Viewer
Location:
chromosome: 37
Exon count:
9
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 37 NC_051841.1 (30888770..30912784)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 37 NC_006619.4 (31632530..31649934)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 37 NC_049258.1 (30752705..30770116)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 37 NC_049297.1 (30804432..30821842)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 37 NC_049778.1 (30743370..30760756)

Chromosome 37 - NC_051841.1Genomic Context describing neighboring genes Neighboring gene elongation factor 1-alpha 1-like Neighboring gene E3 ubiquitin-protein ligase RING2-like

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A mutation in the CLN8 gene in English Setter dogs with neuronal ceroid-lipofuscinosis. Katz ML, et al. Biochem Biophys Res Commun, 2005 Feb 11. PMID 15629147
  2. The molecular genetic basis of the neuronal ceroid lipofuscinoses. Gardiner RM. Neurol Sci, 2000. PMID 11073223
  3. Characterization of candidate genes for neuronal ceroid lipofuscinosis in dog. Drögemüller C, et al. J Hered, 2005. PMID 15958790
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the CLN8 T-to-C transition is the likely cause of English Setter neuronal ceroid-lipofuscinosis
    Title: A mutation in the CLN8 gene in English Setter dogs with neuronal ceroid-lipofuscinosis.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RefSeq

Process Evidence Code Pubs
involved_in lipid homeostasis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
protein CLN8

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012343.1 → NP_001012343.1  protein CLN8

    See identical proteins and their annotated locations for NP_001012343.1

    Status: PROVISIONAL

    Source sequence(s)
    AJ875419
    UniProtKB/Swiss-Prot
    Q2VUD9, Q5JZQ7
    UniProtKB/TrEMBL
    A0A8C0R8J9
    Related
    ENSCAFP00845026384.1, ENSCAFT00845033703.1
    Conserved Domains (1) summary
    smart00724
    Location:64 → 262
    TLC; TRAM, LAG1 and CLN8 homology domains

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051841.1 Reference ROS_Cfam_1.0

    Range
    30888770..30912784
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038447323.1 → XP_038303251.1  protein CLN8 isoform X1

    UniProtKB/Swiss-Prot
    Q2VUD9, Q5JZQ7
    UniProtKB/TrEMBL
    A0A8C0R8J9
    Conserved Domains (1) summary
    smart00724
    Location:64 → 262
    TLC; TRAM, LAG1 and CLN8 homology domains

  2. XM_038447326.1 → XP_038303254.1  protein CLN8 isoform X1

    UniProtKB/Swiss-Prot
    Q2VUD9, Q5JZQ7
    UniProtKB/TrEMBL
    A0A8C0R8J9
    Conserved Domains (1) summary
    smart00724
    Location:64 → 262
    TLC; TRAM, LAG1 and CLN8 homology domains

  3. XM_038447324.1 → XP_038303252.1  protein CLN8 isoform X1

    UniProtKB/Swiss-Prot
    Q2VUD9, Q5JZQ7
    UniProtKB/TrEMBL
    A0A8C0R8J9
    Conserved Domains (1) summary
    smart00724
    Location:64 → 262
    TLC; TRAM, LAG1 and CLN8 homology domains

  4. XM_038447325.1 → XP_038303253.1  protein CLN8 isoform X1

    UniProtKB/Swiss-Prot
    Q2VUD9, Q5JZQ7
    UniProtKB/TrEMBL
    A0A8C0R8J9
    Conserved Domains (1) summary
    smart00724
    Location:64 → 262
    TLC; TRAM, LAG1 and CLN8 homology domains

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049297.1 Alternate UMICH_Zoey_3.1

    Range
    30804432..30821842
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049778.1 Alternate UNSW_CanFamBas_1.0

    Range
    30743370..30760756
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049258.1 Alternate UU_Cfam_GSD_1.0

    Range
    30752705..30770116
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006619.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    31632530..31649934
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5JZQ7.1 GenPept UniProtKB/Swiss-Prot:Q5JZQ7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials