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SLC4A3 solute carrier family 4 member 3 [ Canis lupus familiaris (dog) ]

Gene ID: 488542, updated on 17-Aug-2024

Summary

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Official Symbol
SLC4A3provided by VGNC
Official Full Name
solute carrier family 4 member 3provided by VGNC
Primary source
VGNC:VGNC:46433
See related
Ensembl:ENSCAFG00845030591
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See SLC4A3 in Genome Data Viewer
Location:
chromosome: 37
Exon count:
23
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 37 NC_051841.1 (26151769..26167414)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 37 NC_006619.4 (26962037..26974762)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 37 NC_049258.1 (26012382..26025125)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 37 NC_049297.1 (26055607..26068323)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 37 NC_049778.1 (25991659..26004366)

Chromosome 37 - NC_051841.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111094331 Neighboring gene uncharacterized LOC119867967 Neighboring gene serine/threonine kinase 11 interacting protein Neighboring gene uncharacterized LOC111094386 Neighboring gene uncharacterized LOC102151428

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A frameshift mutation in golden retriever dogs with progressive retinal atrophy endorses SLC4A3 as a candidate gene for human retinal degenerations. Downs LM, et al. PLoS One, 2011. PMID 21738669, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables monoatomic anion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables solute:inorganic anion antiporter activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in bicarbonate transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in monoatomic anion transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of intracellular pH IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
anion exchange protein 3
Names
solute carrier family 4, anion exchanger, member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289433.1 → NP_001276362.1  anion exchange protein 3 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, also known as SLC4A3-fl1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    DN880752, DN880753, HQ379706
    UniProtKB/TrEMBL
    A0A8C0RJF0, A0A8I3Q4Q8, E3W283
    Related
    ENSCAFP00845042649.1, ENSCAFT00845054283.1
    Conserved Domains (2) summary
    PHA03247
    Location:4 → 261
    PHA03247; large tegument protein UL36; Provisional
    TIGR00834
    Location:331 → 1236
    ae; anion exchange protein

  2. NM_001289434.1 → NP_001276363.1  anion exchange protein 3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2, also known as SLC4A3-fl2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    DN880752, DN880753, HQ379707
    UniProtKB/TrEMBL
    E3W284
    Related
    ENSCAFP00845042658.1, ENSCAFT00845054293.1
    Conserved Domains (1) summary
    TIGR00834
    Location:322 → 1227
    ae; anion exchange protein

  3. NM_001289435.1 → NP_001276364.1  anion exchange protein 3 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3, also known as SLC4A3-c) contains an alternate 5' terminal exon, compared to variant 1. It encodes isoform 3, which is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    DN880753, HQ379708
    UniProtKB/TrEMBL
    A0A8C0S8F2, E3W285
    Related
    ENSCAFP00845042681.1, ENSCAFT00845054322.1
    Conserved Domains (3) summary
    TIGR00834
    Location:124 → 1029
    ae; anion exchange protein
    pfam00955
    Location:477 → 959
    HCO3_cotransp; HCO3- transporter family
    pfam07565
    Location:159 → 421
    Band_3_cyto; Band 3 cytoplasmic domain

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051841.1 Reference ROS_Cfam_1.0

    Range
    26151769..26167414
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038447322.1 → XP_038303250.1  anion exchange protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A8C0S6Z2, A0A8I3SCR0, A0A8P0TE16
    Conserved Domains (2) summary
    PHA03247
    Location:14 → 192
    PHA03247; large tegument protein UL36; Provisional
    TIGR00834
    Location:262 → 1167
    ae; anion exchange protein

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049297.1 Alternate UMICH_Zoey_3.1

    Range
    26055607..26068323
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049778.1 Alternate UNSW_CanFamBas_1.0

    Range
    25991659..26004366
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049258.1 Alternate UU_Cfam_GSD_1.0

    Range
    26012382..26025125
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006619.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    26962037..26974762
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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