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NPHS1 NPHS1 adhesion molecule, nephrin [ Canis lupus familiaris (dog) ]

Gene ID: 484571, updated on 17-Aug-2024

Summary

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Official Symbol
NPHS1provided by VGNC
Official Full Name
NPHS1 adhesion molecule, nephrinprovided by VGNC
Primary source
VGNC:VGNC:49930
See related
Ensembl:ENSCAFG00845001053
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See NPHS1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
30
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 1 NC_051805.1 (117398061..117417270)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 1 NC_006583.4 (116200457..116219667)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 1 NC_049222.1 (117640917..117659937)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 1 NC_049261.1 (116961589..116980595)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 1 NC_049742.1 (116585120..116604128)

Chromosome 1 - NC_051805.1Genomic Context describing neighboring genes Neighboring gene amyloid beta precursor like protein 1 Neighboring gene uncharacterized LOC106559197 Neighboring gene kirre like nephrin family adhesion molecule 2 Neighboring gene U6 spliceosomal RNA Neighboring gene proline dehydrogenase 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Glomerulopathy and mutations in NPHS1 and KIRREL2 in soft-coated Wheaten Terrier dogs. Littman MP, et al. Mamm Genome, 2013 Apr. PMID 23325127
  2. Expression of nephrin, podocin, α-actinin-4 and α3-integrin in canine renal glomeruli. Kobayashi R, et al. J Comp Pathol, 2011 Aug-Oct. PMID 21388638

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cell adhesion molecule binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cell-cell junction IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
nephrin
Names
NPHS1, nephrin
nephrosis 1, congenital, Finnish type (nephrin)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051805.1 Reference ROS_Cfam_1.0

    Range
    117398061..117417270
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038657359.1 → XP_038513287.1  nephrin isoform X1

    UniProtKB/TrEMBL
    A0A8C0KXT7
    Related
    ENSCAFP00845001442.1, ENSCAFT00845001830.1
    Conserved Domains (6) summary
    cd00063
    Location:994 → 1075
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07686
    Location:91 → 185
    V-set; Immunoglobulin V-set domain
    pfam08205
    Location:194 → 281
    C2-set_2; CD80-like C2-set immunoglobulin domain
    pfam13927
    Location:793 → 873
    Ig_3; Immunoglobulin domain
    cd00096
    Location:892 → 897
    Ig; putative Ig strand A [structural motif]
    cl11960
    Location:887 → 995
    Ig; Immunoglobulin domain

  2. XM_038657360.1 → XP_038513288.1  nephrin isoform X2

    UniProtKB/TrEMBL
    A0A8C0KXT7
    Conserved Domains (6) summary
    cd00063
    Location:994 → 1075
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07686
    Location:91 → 185
    V-set; Immunoglobulin V-set domain
    pfam08205
    Location:194 → 281
    C2-set_2; CD80-like C2-set immunoglobulin domain
    pfam13927
    Location:793 → 873
    Ig_3; Immunoglobulin domain
    cd00096
    Location:892 → 897
    Ig; putative Ig strand A [structural motif]
    cl11960
    Location:887 → 995
    Ig; Immunoglobulin domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049261.1 Alternate UMICH_Zoey_3.1

    Range
    116961589..116980595
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038468476.1 → XP_038324404.1  nephrin isoform X1

  2. XM_038468477.1 → XP_038324405.1  nephrin isoform X2

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049742.1 Alternate UNSW_CanFamBas_1.0

    Range
    116585120..116604128
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038593518.1 → XP_038449446.1  nephrin isoform X1

  2. XM_038593519.1 → XP_038449447.1  nephrin isoform X2

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049222.1 Alternate UU_Cfam_GSD_1.0

    Range
    117640917..117659937
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038529252.1 → XP_038385180.1  nephrin isoform X1

    UniProtKB/TrEMBL
    A0A8C0KXT7

  2. XM_038529253.1 → XP_038385181.1  nephrin isoform X2

    UniProtKB/TrEMBL
    A0A8C0KXT7

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006583.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    116200457..116219667
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_541685.7 → XP_541685.3  nephrin isoform X1

    UniProtKB/TrEMBL
    A0A8C0KXT7
    Conserved Domains (6) summary
    cd00063
    Location:994 → 1075
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07686
    Location:91 → 185
    V-set; Immunoglobulin V-set domain
    pfam08205
    Location:194 → 281
    C2-set_2; CD80-like C2-set immunoglobulin domain
    pfam13927
    Location:793 → 873
    Ig_3; Immunoglobulin domain
    cd00096
    Location:892 → 897
    Ig; putative Ig strand A [structural motif]
    cl11960
    Location:887 → 995
    Ig; Immunoglobulin domain

  2. XM_022403537.2 → XP_022259245.1  nephrin isoform X2

    UniProtKB/TrEMBL
    A0A8C0KXT7
    Conserved Domains (6) summary
    cd00063
    Location:994 → 1075
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07686
    Location:91 → 185
    V-set; Immunoglobulin V-set domain
    pfam08205
    Location:194 → 281
    C2-set_2; CD80-like C2-set immunoglobulin domain
    pfam13927
    Location:793 → 873
    Ig_3; Immunoglobulin domain
    cd00096
    Location:892 → 897
    Ig; putative Ig strand A [structural motif]
    cl11960
    Location:887 → 995
    Ig; Immunoglobulin domain
Nucleotide Protein
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