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KCNQ1 potassium voltage-gated channel subfamily Q member 1 [ Canis lupus familiaris (dog) ]

Gene ID: 483669, updated on 17-Aug-2024

Summary

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Official Symbol
KCNQ1provided by VGNC
Official Full Name
potassium voltage-gated channel subfamily Q member 1provided by VGNC
Primary source
VGNC:VGNC:51877
See related
Ensembl:ENSCAFG00845011629
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See KCNQ1 in Genome Data Viewer
Location:
chromosome: 18
Exon count:
18
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 18 NC_051822.1 (47186461..47510762)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 18 NC_006600.4 (45116523..45440309)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 18 NC_049239.1 (46962029..47285048)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 18 NC_049278.1 (46634218..46955821)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 18 NC_049759.1 (46214974..46538652)

Chromosome 18 - NC_051822.1Genomic Context describing neighboring genes Neighboring gene tumor suppressing subtransferable candidate 4 Neighboring gene transient receptor potential cation channel subfamily M member 5 Neighboring gene uncharacterized LOC119864243 Neighboring gene microRNA mir-8859a Neighboring gene microRNA mir-8859b Neighboring gene uncharacterized LOC119864236 Neighboring gene cyclin dependent kinase inhibitor 1C Neighboring gene solute carrier family 22 member 18

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sudden death associated with QT interval prolongation and KCNQ1 gene mutation in a family of English Springer Spaniels. Ware WA, et al. J Vet Intern Med, 2015 Mar-Apr. PMID 25779927, Free PMC Article
  2. Modulation of KCNQ1 alternative splicing regulates cardiac IKs and action potential repolarization. Lee HC, et al. Heart Rhythm, 2013 Aug. PMID 23608591, Free PMC Article
  3. Feedback remodeling of cardiac potassium current expression: a novel potential mechanism for control of repolarization reserve. Xiao L, et al. Circulation, 2008 Sep 2. PMID 18711016
  4. A phosphoinositide 3-kinase (PI3K)-serum- and glucocorticoid-inducible kinase 1 (SGK1) pathway promotes Kv7.1 channel surface expression by inhibiting Nedd4-2 protein. Andersen MN, et al. J Biol Chem, 2013 Dec 27. PMID 24214981, Free PMC Article
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. An inherited long QT syndrome, associated with a mutation of KCNQ1, is reported in a family of dogs.
    Title: Sudden death associated with QT interval prolongation and KCNQ1 gene mutation in a family of English Springer Spaniels.
  2. Amiloride regulates slow delayed-rectifier potassium current and action potentials with transmural differences and reduces arrhythmogenicity through the modulation of KCNQ1 splicing.
    Title: Modulation of KCNQ1 alternative splicing regulates cardiac IKs and action potential repolarization.
  3. PI3K-SGK1 pathway stabilizes Kv7.1 surface expression by inhibiting Nedd4-2-dependent endocytosis and thereby demonstrates that Nedd4-2 is a key regulator of Kv7.1 localization and turnover in epithelial cells.
    Title: A phosphoinositide 3-kinase (PI3K)-serum- and glucocorticoid-inducible kinase 1 (SGK1) pathway promotes Kv7.1 channel surface expression by inhibiting Nedd4-2 protein.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables voltage-gated potassium channel activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in potassium ion transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of voltage-gated potassium channel complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
potassium voltage-gated channel subfamily KQT member 1; LOW QUALITY PROTEIN: potassium voltage-gated channel subfamily KQT member 1
Names
mutant potassium voltage-gated channel KQT-like subfamily member 1
potassium voltage-gated channel, KQT-like subfamily, member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051822.1 Reference ROS_Cfam_1.0

    Range
    47186461..47510762
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038424639.1 → XP_038280567.1  potassium voltage-gated channel subfamily KQT member 1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0QAC9
    Conserved Domains (2) summary
    pfam00520
    Location:121 → 357
    Ion_trans; Ion transport protein
    pfam03520
    Location:510 → 584
    KCNQ_channel; KCNQ voltage-gated potassium channel

  2. XM_038424640.1 → XP_038280568.1  potassium voltage-gated channel subfamily KQT member 1 isoform X3

    UniProtKB/TrEMBL
    A0A8C0QAC9, A0A8C0RTZ1, A0A8I3N918
    Related
    ENSCAFP00845016303.1, ENSCAFT00845020781.1
    Conserved Domains (2) summary
    pfam00520
    Location:121 → 357
    Ion_trans; Ion transport protein
    pfam03520
    Location:510 → 616
    KCNQ_channel; KCNQ voltage-gated potassium channel

  3. XM_038424641.1 → XP_038280569.1  potassium voltage-gated channel subfamily KQT member 1 isoform X2

    UniProtKB/TrEMBL
    A0A8I3NJY6, A0A8P0NT79
    Conserved Domains (2) summary
    pfam00520
    Location:18 → 217
    Ion_trans; Ion transport protein
    pfam03520
    Location:370 → 444
    KCNQ_channel; KCNQ voltage-gated potassium channel

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049278.1 Alternate UMICH_Zoey_3.1

    Range
    46634218..46955821
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038500923.1 → XP_038356851.1  LOW QUALITY PROTEIN: potassium voltage-gated channel subfamily KQT member 1 isoform X3

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049759.1 Alternate UNSW_CanFamBas_1.0

    Range
    46214974..46538652
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038627710.1 → XP_038483638.1  potassium voltage-gated channel subfamily KQT member 1 isoform X3

    Conserved Domains (2) summary
    pfam00520
    Location:121 → 357
    Ion_trans; Ion transport protein
    pfam03520
    Location:510 → 616
    KCNQ_channel; KCNQ voltage-gated potassium channel

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049239.1 Alternate UU_Cfam_GSD_1.0

    Range
    46962029..47285048
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038563590.1 → XP_038419518.1  potassium voltage-gated channel subfamily KQT member 1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0PU64, A0A8C0QAC9

  2. XM_038563591.1 → XP_038419519.1  potassium voltage-gated channel subfamily KQT member 1 isoform X3

    UniProtKB/TrEMBL
    A0A8C0QAC9, A0A8C0RTZ1, A0A8I3N918
    Conserved Domains (2) summary
    pfam00520
    Location:121 → 357
    Ion_trans; Ion transport protein
    pfam03520
    Location:510 → 616
    KCNQ_channel; KCNQ voltage-gated potassium channel

  3. XM_038563592.1 → XP_038419520.1  potassium voltage-gated channel subfamily KQT member 1 isoform X2

    UniProtKB/TrEMBL
    A0A8I3NJY6, A0A8P0NT79

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006600.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    45116523..45440309
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038454414.1 → XP_038310342.1  potassium voltage-gated channel subfamily KQT member 1 isoform X3

    UniProtKB/TrEMBL
    A0A8C0QAC9, A0A8C0RTZ1, A0A8I3N918
    Conserved Domains (2) summary
    pfam00520
    Location:121 → 357
    Ion_trans; Ion transport protein
    pfam03520
    Location:510 → 616
    KCNQ_channel; KCNQ voltage-gated potassium channel
Nucleotide Protein
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