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RAG1 recombination activating 1 [ Canis lupus familiaris (dog) ]

Gene ID: 483420, updated on 17-Aug-2024

Summary

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Official Symbol
RAG1provided by VGNC
Official Full Name
recombination activating 1provided by VGNC
Primary source
VGNC:VGNC:45326
See related
Ensembl:ENSCAFG00845020263
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See RAG1 in Genome Data Viewer
Location:
chromosome: 18
Exon count:
1
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 18 NC_051822.1 (32241825..32244956, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 18 NC_006600.4 (31238815..31241946, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 18 NC_049239.1 (32033403..32036534, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 18 NC_049278.1 (31811828..31814959, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 18 NC_049759.1 (31396201..31399332, complement)

Chromosome 18 - NC_051822.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111090933 Neighboring gene intraflagellar transport associated protein Neighboring gene recombination activating 2 Neighboring gene uncharacterized LOC100687377 Neighboring gene TNF receptor associated factor 6 Neighboring gene uncharacterized LOC111090934

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Severe combined immunodeficiency in Frisian Water Dogs caused by a RAG1 mutation. Verfuurden B, et al. Genes Immun, 2011 Jun. PMID 21293384
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables double-stranded DNA endonuclease activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in V(D)J recombination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in adaptive immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in pre-B cell allelic exclusion IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of DNA recombinase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of endodeoxyribonuclease complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
V(D)J recombination-activating protein 1
XP_038279430.1
XP_038357682.1
XP_038418384.1
XP_038482480.1
XP_540538.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051822.1 Reference ROS_Cfam_1.0

    Range
    32241825..32244956 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038423502.1 → XP_038279430.1  V(D)J recombination-activating protein 1

    UniProtKB/TrEMBL
    A0A8C0JZK5, A0A8C0M5P3, A0A8C0SIL6, A0A8I3PC48
    Related
    ENSCAFP00845027912.1, ENSCAFT00845035675.1
    Conserved Domains (4) summary
    pfam10426
    Location:354 → 382
    zf-RAG1; Recombination-activating protein 1 zinc-finger domain
    pfam12940
    Location:386 → 1015
    RAG1; Recombination-activation protein 1 (RAG1), recombinase
    cd16530
    Location:289 → 334
    RING-HC_RAG1; RING finger, HC subclass, found in recombination activating gene-1 (RAG-1) and similar proteins
    pfam12560
    Location:12 → 290
    RAG1_imp_bd; RAG1 importin binding

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049278.1 Alternate UMICH_Zoey_3.1

    Range
    31811828..31814959 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038501754.1 → XP_038357682.1  V(D)J recombination-activating protein 1

    Conserved Domains (4) summary
    pfam10426
    Location:354 → 382
    zf-RAG1; Recombination-activating protein 1 zinc-finger domain
    pfam12940
    Location:386 → 1015
    RAG1; Recombination-activation protein 1 (RAG1), recombinase
    cd16530
    Location:289 → 334
    RING-HC_RAG1; RING finger, HC subclass, found in recombination activating gene-1 (RAG-1) and similar proteins
    pfam12560
    Location:12 → 290
    RAG1_imp_bd; RAG1 importin binding

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049759.1 Alternate UNSW_CanFamBas_1.0

    Range
    31396201..31399332 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038626552.1 → XP_038482480.1  V(D)J recombination-activating protein 1

    Conserved Domains (4) summary
    pfam10426
    Location:354 → 382
    zf-RAG1; Recombination-activating protein 1 zinc-finger domain
    pfam12940
    Location:386 → 1015
    RAG1; Recombination-activation protein 1 (RAG1), recombinase
    cd16530
    Location:289 → 334
    RING-HC_RAG1; RING finger, HC subclass, found in recombination activating gene-1 (RAG-1) and similar proteins
    pfam12560
    Location:12 → 290
    RAG1_imp_bd; RAG1 importin binding

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049239.1 Alternate UU_Cfam_GSD_1.0

    Range
    32033403..32036534 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038562456.1 → XP_038418384.1  V(D)J recombination-activating protein 1

    UniProtKB/TrEMBL
    A0A8C0JZK5, A0A8C0M5P3, A0A8C0SIL6, A0A8I3PC48
    Conserved Domains (4) summary
    pfam10426
    Location:354 → 382
    zf-RAG1; Recombination-activating protein 1 zinc-finger domain
    pfam12940
    Location:386 → 1015
    RAG1; Recombination-activation protein 1 (RAG1), recombinase
    cd16530
    Location:289 → 334
    RING-HC_RAG1; RING finger, HC subclass, found in recombination activating gene-1 (RAG-1) and similar proteins
    pfam12560
    Location:12 → 290
    RAG1_imp_bd; RAG1 importin binding

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006600.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    31238815..31241946 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_540538.3 → XP_540538.1  V(D)J recombination-activating protein 1

    UniProtKB/TrEMBL
    A0A8C0JZK5, A0A8C0M5P3, A0A8C0SIL6, A0A8I3PC48
    Conserved Domains (4) summary
    pfam10426
    Location:354 → 382
    zf-RAG1; Recombination-activating protein 1 zinc-finger domain
    pfam12940
    Location:386 → 1015
    RAG1; Recombination-activation protein 1 (RAG1), recombinase
    cd16530
    Location:289 → 334
    RING-HC_RAG1; RING finger, HC subclass, found in recombination activating gene-1 (RAG-1) and similar proteins
    pfam12560
    Location:12 → 290
    RAG1_imp_bd; RAG1 importin binding
Nucleotide Protein
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