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ADAMTS2 ADAM metallopeptidase with thrombospondin type 1 motif 2 [ Canis lupus familiaris (dog) ]

Gene ID: 481453, updated on 17-Aug-2024

Summary

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Official Symbol
ADAMTS2provided by VGNC
Official Full Name
ADAM metallopeptidase with thrombospondin type 1 motif 2provided by VGNC
Primary source
VGNC:VGNC:37598
See related
Ensembl:ENSCAFG00845008674
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See ADAMTS2 in Genome Data Viewer
Location:
chromosome: 11
Exon count:
21
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 11 NC_051815.1 (2257166..2480747)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 11 NC_006593.4 (2405139..2628591)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 11 NC_049232.1 (2547778..2771332)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 11 NC_049271.1 (2228645..2452092)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 11 NC_049752.1 (2306958..2530502)

Chromosome 11 - NC_051815.1Genomic Context describing neighboring genes Neighboring gene RUN and FYVE domain containing 1 Neighboring gene uncharacterized LOC111097914 Neighboring gene small nucleolar RNA SNORA54 Neighboring gene uncharacterized LOC111097978 Neighboring gene zinc finger protein 879 Neighboring gene glutamate metabotropic receptor 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A homozygous ADAMTS2 nonsense mutation in a Doberman Pinscher dog with Ehlers Danlos syndrome and extreme skin fragility. Jaffey JA, et al. Anim Genet, 2019 Oct. PMID 31294848, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in extracellular matrix organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
A disintegrin and metalloproteinase with thrombospondin motifs 2
XP_038347070.1
XP_038407576.1
XP_038471470.1
XP_038516334.1
XP_038536966.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051815.1 Reference ROS_Cfam_1.0

    Range
    2257166..2480747
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038681038.1 → XP_038536966.1  A disintegrin and metalloproteinase with thrombospondin motifs 2

    UniProtKB/TrEMBL
    A0A8C0MFB3, A0A8C0RDN8
    Related
    ENSCAFP00845012082.1, ENSCAFT00845015551.1
    Conserved Domains (6) summary
    smart00209
    Location:543 → 595
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:245 → 446
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam05986
    Location:702 → 816
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam01562
    Location:62 → 189
    Pep_M12B_propep; Reprolysin family propeptide
    pfam17771
    Location:461 → 530
    ADAM_CR_2; ADAM cysteine-rich domain
    pfam19030
    Location:897 → 954
    TSP1_ADAMTS; Thrombospondin type 1 domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049271.1 Alternate UMICH_Zoey_3.1

    Range
    2228645..2452092
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038491142.1 → XP_038347070.1  A disintegrin and metalloproteinase with thrombospondin motifs 2

    Conserved Domains (6) summary
    smart00209
    Location:543 → 595
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:245 → 446
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam05986
    Location:702 → 816
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam01562
    Location:62 → 189
    Pep_M12B_propep; Reprolysin family propeptide
    pfam17771
    Location:461 → 530
    ADAM_CR_2; ADAM cysteine-rich domain
    pfam19030
    Location:897 → 954
    TSP1_ADAMTS; Thrombospondin type 1 domain

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049752.1 Alternate UNSW_CanFamBas_1.0

    Range
    2306958..2530502
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038615542.1 → XP_038471470.1  A disintegrin and metalloproteinase with thrombospondin motifs 2

    Conserved Domains (6) summary
    smart00209
    Location:543 → 595
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:245 → 446
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam05986
    Location:702 → 816
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam01562
    Location:62 → 189
    Pep_M12B_propep; Reprolysin family propeptide
    pfam17771
    Location:461 → 530
    ADAM_CR_2; ADAM cysteine-rich domain
    pfam19030
    Location:897 → 954
    TSP1_ADAMTS; Thrombospondin type 1 domain

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049232.1 Alternate UU_Cfam_GSD_1.0

    Range
    2547778..2771332
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038551648.1 → XP_038407576.1  A disintegrin and metalloproteinase with thrombospondin motifs 2

    UniProtKB/TrEMBL
    A0A8C0MFB3, A0A8C0RDN8
    Conserved Domains (6) summary
    smart00209
    Location:543 → 595
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:245 → 446
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam05986
    Location:702 → 816
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam01562
    Location:62 → 189
    Pep_M12B_propep; Reprolysin family propeptide
    pfam17771
    Location:461 → 530
    ADAM_CR_2; ADAM cysteine-rich domain
    pfam19030
    Location:897 → 954
    TSP1_ADAMTS; Thrombospondin type 1 domain

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006593.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    2405139..2628591
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038660406.1 → XP_038516334.1  A disintegrin and metalloproteinase with thrombospondin motifs 2

    UniProtKB/TrEMBL
    A0A8C0MFB3, A0A8C0RDN8
    Conserved Domains (6) summary
    smart00209
    Location:543 → 595
    TSP1; Thrombospondin type 1 repeats
    cd04273
    Location:245 → 446
    ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
    pfam05986
    Location:702 → 816
    ADAM_spacer1; ADAM-TS Spacer 1
    pfam01562
    Location:62 → 189
    Pep_M12B_propep; Reprolysin family propeptide
    pfam17771
    Location:461 → 530
    ADAM_CR_2; ADAM cysteine-rich domain
    pfam19030
    Location:897 → 954
    TSP1_ADAMTS; Thrombospondin type 1 domain
Nucleotide Protein
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