MYH9 myosin heavy chain 9 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: MYH9provided by VGNC
Official Full Name: myosin heavy chain 9provided by VGNC
Primary source: VGNC:VGNC:43540
See related: Ensembl:ENSCAFG00845008811
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 41

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	10	NC_051814.1 (28817559..28909010)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	10	NC_006592.4 (27985072..28076495)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	10	NC_049231.1 (29031010..29122482)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	10	NC_049270.1 (28544285..28635641)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	10	NC_049751.1 (28853021..28944583)

Chromosome 10 - NC_051814.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

we identified seven SNPs within the myosin heavy chain 9 gene (MYH9) that were significantly associated with heat tolerance in sprint dogs, two of which correspond to conserved promoter and enhancer regions in the human ortholog.
Title: Breed-specific ancestry studies and genome-wide association analysis highlight an association between the MYH9 gene and heat tolerance in Alaskan sprint racing sled dogs.
case report of point mutation resulting in May-Hegglin anomaly
Title: May-Hegglin anomaly in a dog.
Haplotype sharing excludes orthologous COL4A3, COL4A4 or MYH9 loci in hereditary nephritis in bull terriers.
Title: Haplotype sharing excludes orthologous COL4A3, COL4A4 or MYH9 loci in hereditary nephritis in bull terriers.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables actin filament binding	IEA Inferred from Electronic Annotation more info	PubMed
enables cytoskeletal motor activity	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of myosin complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: myosin-9

Names: NMMHC II-a; NMMHC-IIA; myosin heavy chain, non-muscle IIa; myosin, heavy polypeptide 9, non-muscle; non-muscle myosin heavy chain IIa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001110767.1 → NP_001104237.1 myosin-9

See identical proteins and their annotated locations for NP_001104237.1

Status: PROVISIONAL

Source sequence(s)

AM086385

UniProtKB/Swiss-Prot

Q258K2

UniProtKB/TrEMBL

A0A8I3N9N7, A0A8P0T982

Related

ENSCAFP00845012057.1, ENSCAFT00845015523.1

Conserved Domains (7) summary

cl22853
Location:95 → 764

Motor_domain; Myosin and Kinesin motor domain

pfam00063
Location:83 → 764

Myosin_head; Myosin head (motor domain)

pfam01576
Location:841 → 1921

Myosin_tail_1; Myosin tail

pfam02736
Location:30 → 68

Myosin_N; Myosin N-terminal SH3-like domain

cl00240
Location:1206 → 1263

RRF; Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another round of ...

cl14813
Location:1055 → 1208

GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)

cl23720
Location:1480 → 1587

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)