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SEL1L SEL1L adaptor subunit of ERAD E3 ubiquitin ligase [ Canis lupus familiaris (dog) ]

Gene ID: 480409, updated on 17-Aug-2024

Summary

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Official Symbol
SEL1Lprovided by VGNC
Official Full Name
SEL1L adaptor subunit of ERAD E3 ubiquitin ligaseprovided by VGNC
Primary source
VGNC:VGNC:54990
See related
Ensembl:ENSCAFG00845009244
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See SEL1L in Genome Data Viewer
Location:
chromosome: 8
Exon count:
22
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 8 NC_051812.1 (53998407..54055128, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 8 NC_006590.4 (53325952..53382542, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 8 NC_049229.1 (54075302..54132159, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 8 NC_049268.1 (53678556..53735166, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 8 NC_049749.1 (53683173..53739757, complement)

Chromosome 8 - NC_051812.1Genomic Context describing neighboring genes Neighboring gene stonin 2 Neighboring gene uncharacterized LOC102153608 Neighboring gene uncharacterized LOC102153667 Neighboring gene uncharacterized LOC102153790 Neighboring gene microRNA mir-8884 Neighboring gene uncharacterized LOC119873009

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A SEL1L mutation links a canine progressive early-onset cerebellar ataxia to the endoplasmic reticulum-associated protein degradation (ERAD) machinery. Kyöstilä K, et al. PLoS Genet, 2012. PMID 22719266, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in ERAD pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
protein sel-1 homolog 1
Names
SEL1L, ERAD E3 ligase adaptor subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051812.1 Reference ROS_Cfam_1.0

    Range
    53998407..54055128 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038674398.1 → XP_038530326.1  protein sel-1 homolog 1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0MAG8, A0A8C0RBU2, A0A8P0TFQ6
    Related
    ENSCAFP00845012752.1, ENSCAFT00845016392.1
    Conserved Domains (3) summary
    smart00059
    Location:120 → 168
    FN2; Fibronectin type 2 domain
    COG0790
    Location:412 → 696
    TPR; TPR repeat [Signal transduction mechanisms]
    sd00010
    Location:393 → 422
    SLR; SLR repeat [structural motif]

  2. XM_038674399.1 → XP_038530327.1  protein sel-1 homolog 1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0M3J3, A0A8I3NMQ7, A0A8P0NIQ0
    Related
    ENSCAFP00845012681.1, ENSCAFT00845016298.1
    Conserved Domains (3) summary
    smart00059
    Location:120 → 168
    FN2; Fibronectin type 2 domain
    COG0790
    Location:412 → 696
    TPR; TPR repeat [Signal transduction mechanisms]
    sd00010
    Location:393 → 422
    SLR; SLR repeat [structural motif]

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049268.1 Alternate UMICH_Zoey_3.1

    Range
    53678556..53735166 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038483992.1 → XP_038339920.1  protein sel-1 homolog 1 isoform X3

RNA

  1. XR_005329797.1 RNA Sequence

  2. XR_005329798.1 RNA Sequence

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049749.1 Alternate UNSW_CanFamBas_1.0

    Range
    53683173..53739757 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038609577.1 → XP_038465505.1  protein sel-1 homolog 1 isoform X1

    Conserved Domains (3) summary
    smart00059
    Location:120 → 168
    FN2; Fibronectin type 2 domain
    COG0790
    Location:412 → 696
    TPR; TPR repeat [Signal transduction mechanisms]
    sd00010
    Location:393 → 422
    SLR; SLR repeat [structural motif]

  2. XM_038609578.1 → XP_038465506.1  protein sel-1 homolog 1 isoform X2

    Conserved Domains (3) summary
    smart00059
    Location:120 → 168
    FN2; Fibronectin type 2 domain
    COG0790
    Location:412 → 696
    TPR; TPR repeat [Signal transduction mechanisms]
    sd00010
    Location:393 → 422
    SLR; SLR repeat [structural motif]

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049229.1 Alternate UU_Cfam_GSD_1.0

    Range
    54075302..54132159 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038545485.1 → XP_038401413.1  protein sel-1 homolog 1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0MAG8, A0A8C0RBU2, A0A8P0TFQ6
    Conserved Domains (3) summary
    smart00059
    Location:120 → 168
    FN2; Fibronectin type 2 domain
    COG0790
    Location:412 → 696
    TPR; TPR repeat [Signal transduction mechanisms]
    sd00010
    Location:393 → 422
    SLR; SLR repeat [structural motif]

  2. XM_038545486.1 → XP_038401414.1  protein sel-1 homolog 1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0M3J3, A0A8I3NMQ7, A0A8P0NIQ0
    Conserved Domains (3) summary
    smart00059
    Location:120 → 168
    FN2; Fibronectin type 2 domain
    COG0790
    Location:412 → 696
    TPR; TPR repeat [Signal transduction mechanisms]
    sd00010
    Location:393 → 422
    SLR; SLR repeat [structural motif]

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006590.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    53325952..53382542 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_022422296.2 → XP_022278004.1  protein sel-1 homolog 1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0MAG8, A0A8C0RBU2, A0A8P0TFQ6
    Conserved Domains (3) summary
    smart00059
    Location:120 → 168
    FN2; Fibronectin type 2 domain
    COG0790
    Location:412 → 696
    TPR; TPR repeat [Signal transduction mechanisms]
    sd00010
    Location:393 → 422
    SLR; SLR repeat [structural motif]

  2. XM_537530.7 → XP_537530.2  protein sel-1 homolog 1 isoform X2

    UniProtKB/TrEMBL
    A0A8C0M3J3, A0A8I3NMQ7, A0A8P0NIQ0
    Conserved Domains (3) summary
    smart00059
    Location:120 → 168
    FN2; Fibronectin type 2 domain
    COG0790
    Location:412 → 696
    TPR; TPR repeat [Signal transduction mechanisms]
    sd00010
    Location:393 → 422
    SLR; SLR repeat [structural motif]
Nucleotide Protein
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