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SUV39H2 SUV39H2 histone lysine methyltransferase [ Canis lupus familiaris (dog) ]

Gene ID: 477995, updated on 17-Aug-2024

Summary

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Official Symbol
SUV39H2provided by VGNC
Official Full Name
SUV39H2 histone lysine methyltransferaseprovided by VGNC
Primary source
VGNC:VGNC:84435
See related
Ensembl:ENSCAFG00845014927
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See SUV39H2 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
9
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 2 NC_051806.1 (22017081..22051385, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 2 NC_006584.4 (18828959..18863033, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 2 NC_049223.1 (20679024..20713098, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 2 NC_049262.1 (19228679..19251776, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 2 NC_049743.1 (20052418..20086507, complement)

Chromosome 2 - NC_051806.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC119870141 Neighboring gene DNA cross-link repair 1C Neighboring gene uncharacterized LOC119870145 Neighboring gene uncharacterized LOC111091499 Neighboring gene heat shock protein family A (Hsp70) member 14 Neighboring gene Myb/SANT DNA binding domain containing 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. SUV39H2 epigenetic silencing controls fate conversion of epidermal stem and progenitor cells. Balmer P, et al. J Cell Biol, 2021 Apr 5. PMID 33604655, Free PMC Article
  2. A splice site variant in the SUV39H2 gene in Greyhounds with nasal parakeratosis. Bauer A, et al. Anim Genet, 2018 Apr. PMID 29423952
  3. A mutation in the SUV39H2 gene in Labrador Retrievers with hereditary nasal parakeratosis (HNPK) provides insights into the epigenetics of keratinocyte differentiation. Jagannathan V, et al. PLoS Genet, 2013. PMID 24098150, Free PMC Article
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SUV39H2 epigenetic silencing controls fate conversion of epidermal stem and progenitor cells.
    Title: SUV39H2 epigenetic silencing controls fate conversion of epidermal stem and progenitor cells.
  2. SUV39H2:c.996+3_996+6delAAGT is the causative genetic variant underlying the observed nasal parakeratosis in Greyhounds
    Title: A splice site variant in the SUV39H2 gene in Greyhounds with nasal parakeratosis.
  3. our data provide evidence that SUV39H2 is involved in the epigenetic regulation of keratinocyte differentiation ensuring proper stratification and tight sealing of the mammalian epidermis
    Title: A mutation in the SUV39H2 gene in Labrador Retrievers with hereditary nasal parakeratosis (HNPK) provides insights into the epigenetics of keratinocyte differentiation.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables histone H3K9 methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
histone-lysine N-methyltransferase SUV39H2; LOW QUALITY PROTEIN: histone-lysine N-methyltransferase SUV39H2
Names
suppressor of variegation 3-9 homolog 2
XP_005617166.1
XP_005617167.1
XP_005617168.1
XP_005617169.1
XP_005617171.1
XP_038325239.1
XP_038385975.1
XP_038385976.1
XP_038385977.1
XP_038385978.1
XP_038385979.1
XP_038385980.1
XP_038450237.1
XP_038450238.1
XP_038450239.1
XP_038450240.1
XP_038450241.1
XP_038450242.1
XP_038514304.1
XP_038514305.1
XP_038514306.1
XP_038514307.1
XP_038514308.1
XP_038514309.1
XP_535179.2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051806.1 Reference ROS_Cfam_1.0

    Range
    22017081..22051385 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038658381.1 → XP_038514309.1  histone-lysine N-methyltransferase SUV39H2 isoform X5

    UniProtKB/TrEMBL
    A0A8C0Q376
    Conserved Domains (2) summary
    cd18639
    Location:47 → 95
    CD_SUV39H1_like; chromodomain of histone methyltransferase SUV39H1, and similar proteins
    cl40432
    Location:167 → 334
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily

  2. XM_038658377.1 → XP_038514305.1  histone-lysine N-methyltransferase SUV39H2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0Q376
    Conserved Domains (2) summary
    cd18639
    Location:47 → 95
    CD_SUV39H1_like; chromodomain of histone methyltransferase SUV39H1, and similar proteins
    cl40432
    Location:167 → 332
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily

  3. XM_038658376.1 → XP_038514304.1  histone-lysine N-methyltransferase SUV39H2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0NE17, A0A8C0Q376, A0A8I3NL85
    Related
    ENSCAFP00845021054.1, ENSCAFT00845026718.1
    Conserved Domains (2) summary
    cd18639
    Location:47 → 95
    CD_SUV39H1_like; chromodomain of histone methyltransferase SUV39H1, and similar proteins
    cd10532
    Location:167 → 409
    SET_SUV39H2; SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 2 (SUV39H2) and similar proteins

  4. XM_038658380.1 → XP_038514308.1  histone-lysine N-methyltransferase SUV39H2 isoform X4

    UniProtKB/TrEMBL
    A0A8C0NNV8, A0A8C0Q376, A0A8I3NJS2
    Related
    ENSCAFP00845021037.1, ENSCAFT00845026698.1
    Conserved Domains (2) summary
    cd10532
    Location:107 → 349
    SET_SUV39H2; SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 2 (SUV39H2) and similar proteins
    cl28914
    Location:1 → 35
    CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains

  5. XM_038658379.1 → XP_038514307.1  histone-lysine N-methyltransferase SUV39H2 isoform X4

    UniProtKB/TrEMBL
    A0A8C0NNV8, A0A8C0Q376, A0A8I3NJS2
    Conserved Domains (2) summary
    cd10532
    Location:107 → 349
    SET_SUV39H2; SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 2 (SUV39H2) and similar proteins
    cl28914
    Location:1 → 35
    CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains

  6. XM_038658378.1 → XP_038514306.1  histone-lysine N-methyltransferase SUV39H2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0Q376
    Conserved Domains (2) summary
    cd18639
    Location:5 → 41
    CD_SUV39H1_like; chromodomain of histone methyltransferase SUV39H1, and similar proteins
    cd10532
    Location:113 → 355
    SET_SUV39H2; SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 2 (SUV39H2) and similar proteins

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049262.1 Alternate UMICH_Zoey_3.1

    Range
    19228679..19251776 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038469311.1 → XP_038325239.1  LOW QUALITY PROTEIN: histone-lysine N-methyltransferase SUV39H2 isoform X1

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049743.1 Alternate UNSW_CanFamBas_1.0

    Range
    20052418..20086507 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038594314.1 → XP_038450242.1  histone-lysine N-methyltransferase SUV39H2 isoform X5

    Conserved Domains (2) summary
    cd18639
    Location:47 → 95
    CD_SUV39H1_like; chromodomain of histone methyltransferase SUV39H1, and similar proteins
    cl40432
    Location:167 → 334
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily

  2. XM_038594313.1 → XP_038450241.1  histone-lysine N-methyltransferase SUV39H2 isoform X4

    Conserved Domains (2) summary
    cd10532
    Location:107 → 349
    SET_SUV39H2; SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 2 (SUV39H2) and similar proteins
    cl28914
    Location:1 → 35
    CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains

  3. XM_038594310.1 → XP_038450238.1  histone-lysine N-methyltransferase SUV39H2 isoform X2

    Conserved Domains (2) summary
    cd18639
    Location:47 → 95
    CD_SUV39H1_like; chromodomain of histone methyltransferase SUV39H1, and similar proteins
    cl40432
    Location:167 → 332
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily

  4. XM_038594309.1 → XP_038450237.1  histone-lysine N-methyltransferase SUV39H2 isoform X1

    Conserved Domains (2) summary
    cd18639
    Location:47 → 95
    CD_SUV39H1_like; chromodomain of histone methyltransferase SUV39H1, and similar proteins
    cd10532
    Location:167 → 409
    SET_SUV39H2; SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 2 (SUV39H2) and similar proteins

  5. XM_038594312.1 → XP_038450240.1  histone-lysine N-methyltransferase SUV39H2 isoform X4

    Conserved Domains (2) summary
    cd10532
    Location:107 → 349
    SET_SUV39H2; SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 2 (SUV39H2) and similar proteins
    cl28914
    Location:1 → 35
    CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains

  6. XM_038594311.1 → XP_038450239.1  histone-lysine N-methyltransferase SUV39H2 isoform X3

    Conserved Domains (2) summary
    cd18639
    Location:5 → 41
    CD_SUV39H1_like; chromodomain of histone methyltransferase SUV39H1, and similar proteins
    cd10532
    Location:113 → 355
    SET_SUV39H2; SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 2 (SUV39H2) and similar proteins

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049223.1 Alternate UU_Cfam_GSD_1.0

    Range
    20679024..20713098 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038530052.1 → XP_038385980.1  histone-lysine N-methyltransferase SUV39H2 isoform X5

    UniProtKB/TrEMBL
    A0A8C0Q376
    Conserved Domains (2) summary
    cd18639
    Location:47 → 95
    CD_SUV39H1_like; chromodomain of histone methyltransferase SUV39H1, and similar proteins
    cl40432
    Location:167 → 334
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily

  2. XM_038530051.1 → XP_038385979.1  histone-lysine N-methyltransferase SUV39H2 isoform X4

    UniProtKB/TrEMBL
    A0A8C0NNV8, A0A8C0Q376, A0A8I3NJS2
    Conserved Domains (2) summary
    cd10532
    Location:107 → 349
    SET_SUV39H2; SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 2 (SUV39H2) and similar proteins
    cl28914
    Location:1 → 35
    CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains

  3. XM_038530048.1 → XP_038385976.1  histone-lysine N-methyltransferase SUV39H2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0Q376
    Conserved Domains (2) summary
    cd18639
    Location:47 → 95
    CD_SUV39H1_like; chromodomain of histone methyltransferase SUV39H1, and similar proteins
    cl40432
    Location:167 → 332
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily

  4. XM_038530047.1 → XP_038385975.1  histone-lysine N-methyltransferase SUV39H2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0NE17, A0A8C0Q376, A0A8I3NL85
    Conserved Domains (2) summary
    cd18639
    Location:47 → 95
    CD_SUV39H1_like; chromodomain of histone methyltransferase SUV39H1, and similar proteins
    cd10532
    Location:167 → 409
    SET_SUV39H2; SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 2 (SUV39H2) and similar proteins

  5. XM_038530050.1 → XP_038385978.1  histone-lysine N-methyltransferase SUV39H2 isoform X4

    UniProtKB/TrEMBL
    A0A8C0NNV8, A0A8C0Q376, A0A8I3NJS2
    Conserved Domains (2) summary
    cd10532
    Location:107 → 349
    SET_SUV39H2; SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 2 (SUV39H2) and similar proteins
    cl28914
    Location:1 → 35
    CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains

  6. XM_038530049.1 → XP_038385977.1  histone-lysine N-methyltransferase SUV39H2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0Q376
    Conserved Domains (2) summary
    cd18639
    Location:5 → 41
    CD_SUV39H1_like; chromodomain of histone methyltransferase SUV39H1, and similar proteins
    cd10532
    Location:113 → 355
    SET_SUV39H2; SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 2 (SUV39H2) and similar proteins

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006584.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    18828959..18863033 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005617114.4 → XP_005617171.1  histone-lysine N-methyltransferase SUV39H2 isoform X5

    UniProtKB/TrEMBL
    A0A8C0Q376
    Conserved Domains (2) summary
    cd18639
    Location:47 → 95
    CD_SUV39H1_like; chromodomain of histone methyltransferase SUV39H1, and similar proteins
    cl40432
    Location:167 → 334
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily

  2. XM_005617111.3 → XP_005617168.1  histone-lysine N-methyltransferase SUV39H2 isoform X4

    See identical proteins and their annotated locations for XP_005617168.1

    UniProtKB/TrEMBL
    A0A8C0NNV8, A0A8C0Q376, A0A8I3NJS2
    Conserved Domains (2) summary
    cd10532
    Location:107 → 349
    SET_SUV39H2; SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 2 (SUV39H2) and similar proteins
    cl28914
    Location:1 → 35
    CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains

  3. XM_005617109.4 → XP_005617166.1  histone-lysine N-methyltransferase SUV39H2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0Q376
    Conserved Domains (2) summary
    cd18639
    Location:47 → 95
    CD_SUV39H1_like; chromodomain of histone methyltransferase SUV39H1, and similar proteins
    cl40432
    Location:167 → 332
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily

  4. XM_535179.7 → XP_535179.2  histone-lysine N-methyltransferase SUV39H2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0NE17, A0A8C0Q376, A0A8I3NL85
    Conserved Domains (2) summary
    cd18639
    Location:47 → 95
    CD_SUV39H1_like; chromodomain of histone methyltransferase SUV39H1, and similar proteins
    cd10532
    Location:167 → 409
    SET_SUV39H2; SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 2 (SUV39H2) and similar proteins

  5. XM_005617112.4 → XP_005617169.1  histone-lysine N-methyltransferase SUV39H2 isoform X4

    See identical proteins and their annotated locations for XP_005617169.1

    UniProtKB/TrEMBL
    A0A8C0NNV8, A0A8C0Q376, A0A8I3NJS2
    Conserved Domains (2) summary
    cd10532
    Location:107 → 349
    SET_SUV39H2; SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 2 (SUV39H2) and similar proteins
    cl28914
    Location:1 → 35
    CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains

  6. XM_005617110.4 → XP_005617167.1  histone-lysine N-methyltransferase SUV39H2 isoform X3

    UniProtKB/TrEMBL
    A0A8C0Q376
    Conserved Domains (2) summary
    cd18639
    Location:5 → 41
    CD_SUV39H1_like; chromodomain of histone methyltransferase SUV39H1, and similar proteins
    cd10532
    Location:113 → 355
    SET_SUV39H2; SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 2 (SUV39H2) and similar proteins
Nucleotide Protein
Heading Accession and Version

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