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CCDC66 coiled-coil domain containing 66 [ Canis lupus familiaris (dog) ]

Gene ID: 476582, updated on 17-Aug-2024

Summary

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Official Symbol
CCDC66provided by VGNC
Official Full Name
coiled-coil domain containing 66provided by VGNC
Primary source
VGNC:VGNC:38850
See related
Ensembl:ENSCAFG00845024810
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See CCDC66 in Genome Data Viewer
Location:
chromosome: 20
Exon count:
23
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 20 NC_051824.1 (33985924..34030861, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 20 NC_006602.4 (33641146..33685866, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 20 NC_049241.1 (33963454..34008410, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 20 NC_049280.1 (33430153..33474916, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 20 NC_049761.1 (33789795..33834395, complement)

Chromosome 20 - NC_051824.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102152719 Neighboring gene transcription activation suppressor Neighboring gene uncharacterized LOC102156537 Neighboring gene uncharacterized LOC119864585

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. CCDC66 frameshift variant associated with a new form of early-onset progressive retinal atrophy in Portuguese Water Dogs. Murgiano L, et al. Sci Rep, 2020 Dec 3. PMID 33273526, Free PMC Article
  2. Progressive retinal atrophy in Schapendoes dogs: mutation of the newly identified CCDC66 gene. Dekomien G, et al. Neurogenetics, 2010 May. PMID 19777273
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CCDC66 frameshift variant associated with a new form of early-onset progressive retinal atrophy in Portuguese Water Dogs.
    Title: CCDC66 frameshift variant associated with a new form of early-onset progressive retinal atrophy in Portuguese Water Dogs.
  2. Results describe a generalized progressive retinal atrophy locus comprising the newly identified gene coiled-coil domain containing 66 (CCDC66) on canine chromosome 20, as identified via linkage analysis.
    Title: Progressive retinal atrophy in Schapendoes dogs: mutation of the newly identified CCDC66 gene.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cilium assembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cilium IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in photoreceptor inner segment IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
coiled-coil domain-containing protein 66

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168012.1 → NP_001161484.1  coiled-coil domain-containing protein 66

    See identical proteins and their annotated locations for NP_001161484.1

    Status: PROVISIONAL

    Source sequence(s)
    FN433897
    UniProtKB/Swiss-Prot
    D0R7H6, F1PZQ5
    UniProtKB/TrEMBL
    A0A8C0PIN9
    Related
    ENSCAFP00845034938.1, ENSCAFT00845044596.1
    Conserved Domains (1) summary
    pfam15236
    Location:412 → 563
    CCDC66; Coiled-coil domain-containing protein 66

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051824.1 Reference ROS_Cfam_1.0

    Range
    33985924..34030861 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038426421.1 → XP_038282349.1  coiled-coil domain-containing protein 66 isoform X1

    UniProtKB/TrEMBL
    A0A8I3PTR5
    Related
    ENSCAFP00845034712.1, ENSCAFT00845044299.1
    Conserved Domains (1) summary
    pfam15236
    Location:418 → 569
    CCDC66; Coiled-coil domain-containing protein 66

  2. XM_038426422.1 → XP_038282350.1  coiled-coil domain-containing protein 66 isoform X2

    UniProtKB/TrEMBL
    A0A8I3PUE0
    Related
    ENSCAFP00845035061.1, ENSCAFT00845044745.1
    Conserved Domains (1) summary
    pfam15236
    Location:385 → 536
    CCDC66; Coiled-coil domain-containing protein 66

  3. XM_038426424.1 → XP_038282352.1  coiled-coil domain-containing protein 66 isoform X4

    UniProtKB/Swiss-Prot
    D0R7H6, F1PZQ5
    UniProtKB/TrEMBL
    A0A8C0PIN9
    Conserved Domains (1) summary
    pfam15236
    Location:273 → 424
    CCDC66; Coiled-coil domain-containing protein 66

  4. XM_038426423.1 → XP_038282351.1  coiled-coil domain-containing protein 66 isoform X3

    UniProtKB/Swiss-Prot
    D0R7H6, F1PZQ5
    UniProtKB/TrEMBL
    A0A8C0PIN9, A0A8I3PTZ9
    Conserved Domains (1) summary
    pfam15236
    Location:373 → 524
    CCDC66; Coiled-coil domain-containing protein 66

  5. XM_038426426.1 → XP_038282354.1  coiled-coil domain-containing protein 66 isoform X5

    UniProtKB/TrEMBL
    A0A8C0PIN9
    Conserved Domains (1) summary
    pfam15236
    Location:245 → 396
    CCDC66; Coiled-coil domain-containing protein 66

  6. XM_038426425.1 → XP_038282353.1  coiled-coil domain-containing protein 66 isoform X5

    UniProtKB/TrEMBL
    A0A8C0PIN9
    Conserved Domains (1) summary
    pfam15236
    Location:245 → 396
    CCDC66; Coiled-coil domain-containing protein 66

  7. XM_038426427.1 → XP_038282355.1  coiled-coil domain-containing protein 66 isoform X6

    Conserved Domains (1) summary
    pfam15236
    Location:219 → 370
    CCDC66; Coiled-coil domain-containing protein 66

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049280.1 Alternate UMICH_Zoey_3.1

    Range
    33430153..33474916 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049761.1 Alternate UNSW_CanFamBas_1.0

    Range
    33789795..33834395 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049241.1 Alternate UU_Cfam_GSD_1.0

    Range
    33963454..34008410 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006602.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    33641146..33685866 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F1PZQ5.2 GenPept UniProtKB/Swiss-Prot:F1PZQ5

Gene LinkOut

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Research Materials