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NEDD8 NEDD8 ubiquitin like modifier [ Homo sapiens (human) ]

Gene ID: 4738, updated on 14-Nov-2024

Summary

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Official Symbol
NEDD8provided by HGNC
Official Full Name
NEDD8 ubiquitin like modifierprovided by HGNC
Primary source
HGNC:HGNC:7732
See related
Ensembl:ENSG00000129559 MIM:603171; AllianceGenome:HGNC:7732
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NEDD-8
Summary
Enables ubiquitin protein ligase binding activity. Acts upstream of or within protein neddylation. Located in cytosol and nucleoplasm. Biomarker of Parkinson's disease and malignant astrocytoma. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in fat (RPKM 81.8), kidney (RPKM 81.6) and 25 other tissues See more
Orthologs
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Genomic context

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See NEDD8 in Genome Data Viewer
Location:
14q12
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (24216857..24232367, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (18415233..18430739, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (24686063..24701573, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene charged multivesicular body protein 4A Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:24682177-24682985 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:24683998-24684736 Neighboring gene NEDD8-MDP1 readthrough Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8198 Neighboring gene magnesium dependent phosphatase 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:24701437-24702302 Neighboring gene guanosine monophosphate reductase 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:24710068-24710597 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8199 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8200 Neighboring gene TERF1 interacting nuclear factor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Blocking neddylation elicits antiviral effect against hepatitis B virus replication. Abounouh K, et al. Mol Biol Rep, 2022 Jan. PMID 34716866
  2. Targeting protein neddylation with an NEDD8-activating enzyme inhibitor MLN4924 induced apoptosis or senescence in human lymphoma cells. Wang Y, et al. Cancer Biol Ther, 2015. PMID 25782162, Free PMC Article
  3. Control of cell proliferation via elevated NEDD8 conjugation in oral squamous cell carcinoma. Chairatvit K, et al. Mol Cell Biochem, 2007 Dec. PMID 17660949
  4. NEDD8-mediated neddylation is required for human endometrial stromal proliferation and decidualization. Liao Y, et al. Hum Reprod, 2015 Jul. PMID 26003431
  5. Inhibition of the NEDD8 conjugation pathway by shRNA to UBA3, the subunit of the NEDD8-activating enzyme, suppresses the growth of melanoma cells. Cheng F, et al. Asian Pac J Cancer Prev, 2012. PMID 22502714

See all (275) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss of NEDD8 in cancer cells causes vulnerability to immune checkpoint blockade in triple-negative breast cancer.
    Title: Loss of NEDD8 in cancer cells causes vulnerability to immune checkpoint blockade in triple-negative breast cancer.
  2. Advancements in colorectal cancer research: Unveiling the cellular and molecular mechanisms of neddylation (Review).
    Title: Advancements in colorectal cancer research: Unveiling the cellular and molecular mechanisms of neddylation (Review).
  3. [Differential expression of NEDD8 in different pathological types of chronic rhinosinusitis with nasal polyps].
    Title: [Differential expression of NEDD8 in different pathological types of chronic rhinosinusitis with nasal polyps].
  4. Blocking neddylation elicits antiviral effect against hepatitis B virus replication.
    Title: Blocking neddylation elicits antiviral effect against hepatitis B virus replication.
  5. The Mechanism of NEDD8 Activation of CUL5 Ubiquitin E3 Ligases.
    Title: The Mechanism of NEDD8 Activation of CUL5 Ubiquitin E3 Ligases.
  6. The HSP70 chaperone as sensor of the NEDD8 cycle upon DNA damage.
    Title: The HSP70 chaperone as sensor of the NEDD8 cycle upon DNA damage.
  7. A polydopamine nanomedicine used in photothermal therapy for liver cancer knocks down the anti-cancer target NEDD8-E3 ligase ROC1 (RBX1).
    Title: A polydopamine nanomedicine used in photothermal therapy for liver cancer knocks down the anti-cancer target NEDD8-E3 ligase ROC1 (RBX1).
  8. Map of ubiquitin-like post-translational modifications in chronic lymphocytic leukemia. Role of p53 lysine 120 NEDDylation.
    Title: Map of ubiquitin-like post-translational modifications in chronic lymphocytic leukemia. Role of p53 lysine 120 NEDDylation.
  9. Proteome-wide identification of NEDD8 modification sites reveals distinct proteomes for canonical and atypical NEDDylation.
    Title: Proteome-wide identification of NEDD8 modification sites reveals distinct proteomes for canonical and atypical NEDDylation.
  10. Structural and functional consequences of NEDD8 phosphorylation.
    Title: Structural and functional consequences of NEDD8 phosphorylation.
Submit: New GeneRIF Correction See all GeneRIFs (115)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 complexes with NEDD8 PubMed
vif HIV-1 Vif recruits an active ubiquitin ligase complex composed of Elongin B/C, Cullin5, Nedd8, and Rbx1, which mediates polyubiquitylation of APOBEC3G PubMed
Vpu vpu HIV-1 Vpu is identified to have a physical interaction with neural precursor cell expressed, developmentally down-regulated 8 (NEDD8) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ43224, MGC104393, MGC125896, MGC125897

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein tag activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in anatomical structure morphogenesis TAS
Traceable Author Statement
more info
 PubMed 
involved_in modification-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization IEA
Inferred from Electronic Annotation
more info
  
involved_in protein modification process TAS
Traceable Author Statement
more info
 PubMed 
involved_in protein neddylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein neddylation IDA
Inferred from Direct Assay
more info
 PubMed 
NOT involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of postsynapse assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
NEDD8
Names
neddylin
neural precursor cell expressed, developmentally down-regulated 8
ubiquitin-like protein Nedd8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006156.3 → NP_006147.1  NEDD8

    See identical proteins and their annotated locations for NP_006147.1

    Status: VALIDATED

    Source sequence(s)
    BC104200, BE548741, CF130271
    Consensus CDS
    CCDS9621.1
    UniProtKB/Swiss-Prot
    Q15843, Q3SXN8, Q6LES6
    Related
    ENSP00000250495.5, ENST00000250495.10
    Conserved Domains (1) summary
    cd01806
    Location:3 → 76
    Ubl_NEDD8; ubiquitin-like (Ubl) domain found in neural precursor cell expressed developmentally down-regulated protein 8 (NEDD8) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    24216857..24232367 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_018654722.1 Reference GRCh38.p14 PATCHES

    Range
    517835..533345 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    18415233..18430739 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q15843.1 GenPept UniProtKB/Swiss-Prot:Q15843

Gene LinkOut

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