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NCAM1 neural cell adhesion molecule 1 [ Homo sapiens (human) ]

Gene ID: 4684, updated on 14-Nov-2024

Summary

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Official Symbol
NCAM1provided by HGNC
Official Full Name
neural cell adhesion molecule 1provided by HGNC
Primary source
HGNC:HGNC:7656
See related
Ensembl:ENSG00000149294 MIM:116930; AllianceGenome:HGNC:7656
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD56; NCAM; MSK39
Summary
This gene encodes a cell adhesion protein which is a member of the immunoglobulin superfamily. The encoded protein is involved in cell-to-cell interactions as well as cell-matrix interactions during development and differentiation. The encoded protein plays a role in the development of the nervous system by regulating neurogenesis, neurite outgrowth, and cell migration. This protein is also involved in the expansion of T lymphocytes, B lymphocytes and natural killer (NK) cells which play an important role in immune surveillance. This protein plays a role in signal transduction by interacting with fibroblast growth factor receptors, N-cadherin and other components of the extracellular matrix and by triggering signalling cascades involving FYN-focal adhesion kinase (FAK), mitogen-activated protein kinase (MAPK), and phosphatidylinositol 3-kinase (PI3K). One prominent isoform of this gene, cell surface molecule CD56, plays a role in several myeloproliferative disorders such as acute myeloid leukemia and differential expression of this gene is associated with differential disease progression. For example, increased expression of CD56 is correlated with lower survival in acute myeloid leukemia patients whereas increased severity of COVID-19 is correlated with decreased abundance of CD56-expressing NK cells in peripheral blood. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. [provided by RefSeq, Aug 2020]
Annotation information
Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
Expression
Biased expression in brain (RPKM 90.3), adrenal (RPKM 31.4) and 6 other tissues See more
Orthologs
mouse all
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Genomic context

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See NCAM1 in Genome Data Viewer
Location:
11q23.2
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (112961420..113278436)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (112971836..113288890)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (112832142..113149158)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902801 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:112668663-112669340 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:112669341-112670018 Neighboring gene uncharacterized LOC105369498 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:112692479-112693346 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:112693347-112694212 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:112748461-112748976 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:112752465-112752965 Neighboring gene uncharacterized LOC101928847 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:112832085-112832862 Neighboring gene RNA, U7 small nuclear 187 pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:113017979-113018497 Neighboring gene NCAM1 antisense RNA1 Neighboring gene TTC12 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3908 Neighboring gene Sharpr-MPRA regulatory region 9915 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:113202304-113203503 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr11:113214693-113215892 Neighboring gene tetratricopeptide repeat domain 12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Role of a neural cell adhesion molecule found in cerebrospinal fluid as a potential biomarker for epilepsy. Wang W, et al. Neurochem Res, 2012 Apr. PMID 22219127
  2. Excellent prognosis in a subset of patients with Ewing sarcoma identified at diagnosis by CD56 using flow cytometry. Ash S, et al. Clin Cancer Res, 2011 May 1. PMID 21467162
  3. Transgenic mice overexpressing the extracellular domain of NCAM are impaired in working memory and cortical plasticity. Brennaman LH, et al. Neurobiol Dis, 2011 Aug. PMID 21515372, Free PMC Article
  4. Hepatocellular carcinoma with progenitor cell features distinguishable by the hepatic stem/progenitor cell marker NCAM. Tsuchiya A, et al. Cancer Lett, 2011 Oct 1. PMID 21669487
  5. CD56 expression is associated with neuroectodermal differentiation in ameloblastomas: an immunohistochemical evaluation in comparison with odontogenic cystic lesions. Kusafuka K, et al. Med Mol Morphol, 2011 Jun. PMID 21717310

See all (405) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CD56/NCAM mediates cell migration of human NK cells by promoting integrin-mediated adhesion turnover.
    Title: CD56/NCAM mediates cell migration of human NK cells by promoting integrin-mediated adhesion turnover.
  2. Expression and Clinical Significance of CD30 and CD56 in Lymphoblastic Lymphoma: A Retrospective Analysis on Paraffin-Embedded Tissues by Immunohistochemistry.
    Title: Expression and Clinical Significance of CD30 and CD56 in Lymphoblastic Lymphoma: A Retrospective Analysis on Paraffin-Embedded Tissues by Immunohistochemistry.
  3. Plasma-derived extracellular vesicle surface markers CD45, CD326 and CD56 correlate with the stage of osteoarthritis: a primary study of a novel and promising diagnostic tool of the disease.
    Title: Plasma-derived extracellular vesicle surface markers CD45, CD326 and CD56 correlate with the stage of osteoarthritis: a primary study of a novel and promising diagnostic tool of the disease.
  4. A Comparative Study of CD56 and Smooth Muscle Actin Expression in Basal and Squamous Cell Carcinomas.
    Title: A Comparative Study of CD56 and Smooth Muscle Actin Expression in Basal and Squamous Cell Carcinomas.
  5. Investigation of CD56, ADAM17 and FGF21 Expressions in the Placentas of Preeclampsia Cases.
    Title: Investigation of CD56, ADAM17 and FGF21 Expressions in the Placentas of Preeclampsia Cases.
  6. [Prognostic Value of CD56 Expression in Newly Diagnosed Multiple Myeloma Patients and Its Related Factors].
    Title: [Prognostic Value of CD56 Expression in Newly Diagnosed Multiple Myeloma Patients and Its Related Factors].
  7. CD56-positive diffuse large B-cell lymphoma: comprehensive analysis of clinical, pathological, and molecular characteristics with literature review.
    Title: CD56-positive diffuse large B-cell lymphoma: comprehensive analysis of clinical, pathological, and molecular characteristics with literature review.
  8. Neural cell adhesion molecule 1 is a cellular target engaged plasma biomarker in demyelinating Charcot-Marie-Tooth disease.
    Title: Neural cell adhesion molecule 1 is a cellular target engaged plasma biomarker in demyelinating Charcot-Marie-Tooth disease.
  9. Retrospective Analysis of the Expression of CD56 in Multiple Myeloma with Bone-Related Extramedullary Diseases.
    Title: Retrospective Analysis of the Expression of CD56 in Multiple Myeloma with Bone-Related Extramedullary Diseases.
  10. Evaluating the prognostic value of CD56 in pediatric acute myeloid leukemia.
    Title: Evaluating the prognostic value of CD56 in pediatric acute myeloid leukemia.
Submit: New GeneRIF Correction See all GeneRIFs (333)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic relationships between suicide attempts, suicidal ideation and major psychiatric disorders: a genome-wide association and polygenic scoring study.
EBI GWAS Catalog
Genetic variation in NCAM1 contributes to left ventricular wall thickness in hypertensive families.
EBI GWAS Catalog
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
EBI GWAS Catalog
Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease.
EBI GWAS Catalog

Variation

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See Variation Viewer (GRCh37.p13)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables virus receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in commissural neuron axon guidance ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in epithelial to mesenchymal transition ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of semaphorin-plexin signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in symbiont entry into host cell IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi membrane TAS
Traceable Author Statement
more info
  
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in collagen-containing extracellular matrix HDA PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in membrane HDA PubMed 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
neural cell adhesion molecule 1
Names
antigen recognized by monoclonal antibody 5.1H11
neural cell adhesion molecule, NCAM
NP_000606.3
NP_001070150.1
NP_001229536.1
NP_001229537.1
NP_001373218.1
NP_001373219.1
NP_001373220.1
NP_001373221.1
NP_001387532.1
NP_001387533.1
NP_001387534.1
NP_001387535.1
NP_001387536.1
NP_001387537.1
NP_001387538.1
NP_001387539.1
NP_001387540.1
NP_001387541.1
NP_001387542.1
NP_001387543.1
NP_001387544.1
NP_001387545.1
NP_001387546.1
NP_001387547.1
NP_001387548.1
NP_001387549.1
NP_001387550.1
NP_001387551.1
NP_001387552.1
NP_001387553.1
NP_851996.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032036.2 RefSeqGene

    Range
    5002..322018
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000615.7 → NP_000606.3  neural cell adhesion molecule 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_000606.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks two alternate in-frame exons in the 3' coding region compared to variant 5. The resulting protein (isoform 1) is shorter compared to isoform 5.
    Source sequence(s)
    AK054570, AW131780, BC014205, BC047244, DA337649, S71824
    Consensus CDS
    CCDS73388.1
    Related
    ENSP00000484943.1, ENST00000531044.5
    Conserved Domains (8) summary
    cd05869
    Location:306 → 402
    IgI_NCAM-1; Immunoglobulin (Ig)-like I-set domain of Neural Cell Adhesion Molecule 1 (NCAM-1)
    smart00410
    Location:124 → 190
    IG_like; Immunoglobulin like
    cd00063
    Location:498 → 595
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:603 → 684
    fn3; Fibronectin type III domain
    pfam13927
    Location:411 → 483
    Ig_3; Immunoglobulin domain
    cd00096
    Location:211 → 216
    Ig; Ig strand A [structural motif]
    cd05865
    Location:20 → 116
    IgI_1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule (NCAM-1); member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:211 → 307
    Ig; Immunoglobulin domain

  2. NM_001076682.4 → NP_001070150.1  neural cell adhesion molecule 1 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001070150.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has multiple differences in the coding region and uses an alternate splice site in the 3' coding region compared to variant 5. The resulting protein (isoform 3) is shorter and has a distinct C-terminus compared to isoform 5.
    Source sequence(s)
    AB209443, BC019845, BC047244, DA337649, S71824, X16841
    Consensus CDS
    CCDS73386.1
    Related
    ENSP00000480774.1, ENST00000621850.4
    Conserved Domains (7) summary
    cd05865
    Location:20 → 115
    Ig1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-1
    cd05869
    Location:306 → 402
    Ig_NCAM-1; Immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule NCAM-1 (NCAM)
    smart00409
    Location:124 → 190
    IG; Immunoglobulin
    cd00063
    Location:498 → 595
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:638 → 719
    fn3; Fibronectin type III domain
    pfam13927
    Location:406 → 483
    Ig_3; Immunoglobulin domain
    cl11960
    Location:211 → 307
    Ig; Immunoglobulin domain

  3. NM_001242607.2 → NP_001229536.1  neural cell adhesion molecule 1 isoform 5 precursor

    See identical proteins and their annotated locations for NP_001229536.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) represents the longest transcript and encodes the longest protein (isoform 5).
    Source sequence(s)
    AK314589, AP000880, AP002853
    Consensus CDS
    CCDS73384.1
    UniProtKB/TrEMBL
    A0A087WWD4
    Related
    ENSP00000480132.1, ENST00000619839.4
    Conserved Domains (7) summary
    cd05865
    Location:20 → 115
    Ig1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-1
    smart00409
    Location:124 → 190
    IG; Immunoglobulin
    cd00063
    Location:534 → 631
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:639 → 720
    fn3; Fibronectin type III domain
    pfam13927
    Location:447 → 519
    Ig_3; Immunoglobulin domain
    cl11960
    Location:306 → 438
    Ig; Immunoglobulin domain
    cl25865
    Location:792 → 864
    Trypan_PARP; Procyclic acidic repetitive protein (PARP)

  4. NM_001242608.2 → NP_001229537.1  neural cell adhesion molecule 1 isoform 4 precursor

    See identical proteins and their annotated locations for NP_001229537.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks 2 alternate in-frame exons and uses an alternate splice site in the 3' coding region compared to variant 5. The resulting protein (isoform 4) is shorter and has a distinct C-terminus compared to isoform 5.
    Source sequence(s)
    AA029449, AB209443
    Consensus CDS
    CCDS73387.1
    Related
    ENSP00000481083.1, ENST00000621128.4
    Conserved Domains (8) summary
    cd05869
    Location:306 → 402
    IgI_NCAM-1; Immunoglobulin (Ig)-like I-set domain of Neural Cell Adhesion Molecule 1 (NCAM-1)
    smart00410
    Location:124 → 190
    IG_like; Immunoglobulin like
    cd00063
    Location:498 → 595
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:603 → 684
    fn3; Fibronectin type III domain
    pfam13927
    Location:411 → 483
    Ig_3; Immunoglobulin domain
    cd00096
    Location:211 → 216
    Ig; Ig strand A [structural motif]
    cd05865
    Location:20 → 116
    IgI_1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule (NCAM-1); member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:211 → 307
    Ig; Immunoglobulin domain

  5. NM_001386289.1 → NP_001373218.1  neural cell adhesion molecule 1 isoform 6 precursor

    Status: REVIEWED

    Source sequence(s)
    AP000880, AP002853, FP884230
    Conserved Domains (8) summary
    cd05869
    Location:306 → 412
    IgI_NCAM-1; Immunoglobulin (Ig)-like I-set domain of Neural Cell Adhesion Molecule 1 (NCAM-1)
    smart00410
    Location:124 → 190
    IG_like; Immunoglobulin like
    cd00063
    Location:508 → 605
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:612 → 693
    fn3; Fibronectin type III domain
    pfam13927
    Location:421 → 493
    Ig_3; Immunoglobulin domain
    cd00096
    Location:211 → 216
    Ig; Ig strand A [structural motif]
    cd05865
    Location:20 → 116
    IgI_1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule (NCAM-1); member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:211 → 307
    Ig; Immunoglobulin domain

  6. NM_001386290.1 → NP_001373219.1  neural cell adhesion molecule 1 isoform 7 precursor

    Status: REVIEWED

    Source sequence(s)
    AP000880, AP002853, FP884230
    Conserved Domains (7) summary
    cd05869
    Location:306 → 412
    IgI_NCAM-1; Immunoglobulin (Ig)-like I-set domain of Neural Cell Adhesion Molecule 1 (NCAM-1)
    smart00410
    Location:124 → 190
    IG_like; Immunoglobulin like
    pfam00041
    Location:612 → 693
    fn3; Fibronectin type III domain
    pfam13927
    Location:421 → 493
    Ig_3; Immunoglobulin domain
    cd00096
    Location:211 → 216
    Ig; Ig strand A [structural motif]
    cd05865
    Location:20 → 116
    IgI_1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule (NCAM-1); member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:211 → 307
    Ig; Immunoglobulin domain

  7. NM_001386291.1 → NP_001373220.1  neural cell adhesion molecule 1 isoform 8 precursor

    Status: REVIEWED

    Source sequence(s)
    AP000880, AP002853, FP884230
    Consensus CDS
    CCDS91595.1
    UniProtKB/TrEMBL
    H7BYX6
    Related
    ENSP00000384055.3, ENST00000401611.6
    Conserved Domains (8) summary
    cd05869
    Location:306 → 402
    IgI_NCAM-1; Immunoglobulin (Ig)-like I-set domain of Neural Cell Adhesion Molecule 1 (NCAM-1)
    smart00409
    Location:124 → 190
    IG; Immunoglobulin
    cd00063
    Location:498 → 595
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:602 → 683
    fn3; Fibronectin type III domain
    pfam13927
    Location:411 → 483
    Ig_3; Immunoglobulin domain
    cd00096
    Location:211 → 216
    Ig; Ig strand A [structural motif]
    cd05865
    Location:20 → 116
    IgI_1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule (NCAM-1); member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:211 → 307
    Ig; Immunoglobulin domain

  8. NM_001386292.1 → NP_001373221.1  neural cell adhesion molecule 1 isoform 9 precursor

    Status: REVIEWED

    Source sequence(s)
    AP000880, AP002853, FP884230
    Conserved Domains (7) summary
    cd05869
    Location:306 → 402
    IgI_NCAM-1; Immunoglobulin (Ig)-like I-set domain of Neural Cell Adhesion Molecule 1 (NCAM-1)
    smart00409
    Location:124 → 190
    IG; Immunoglobulin
    pfam00041
    Location:602 → 683
    fn3; Fibronectin type III domain
    pfam13927
    Location:411 → 483
    Ig_3; Immunoglobulin domain
    cd00096
    Location:211 → 216
    Ig; Ig strand A [structural motif]
    cd05865
    Location:20 → 116
    IgI_1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule (NCAM-1); member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:211 → 307
    Ig; Immunoglobulin domain

  9. NM_001400603.1 → NP_001387532.1  neural cell adhesion molecule 1 isoform 10 precursor

    Status: REVIEWED

    Source sequence(s)
    AP000880, AP002853, FP884230

  10. NM_001400604.1 → NP_001387533.1  neural cell adhesion molecule 1 isoform 11 precursor

    Status: REVIEWED

    Source sequence(s)
    AP000880, AP002853, FP884230

  11. NM_001400605.1 → NP_001387534.1  neural cell adhesion molecule 1 isoform 12 precursor

    Status: REVIEWED

    Source sequence(s)
    AP000880, AP002853, FP884230

  12. NM_001400606.1 → NP_001387535.1  neural cell adhesion molecule 1 isoform 13 precursor

    Status: REVIEWED

    Source sequence(s)
    AP000880, AP002853, FP884230

  13. NM_001400607.1 → NP_001387536.1  neural cell adhesion molecule 1 isoform 14 precursor

    Status: REVIEWED

    Source sequence(s)
    AP000880, AP002853, FP884230

  14. NM_001400608.1 → NP_001387537.1  neural cell adhesion molecule 1 isoform 15 precursor

    Status: REVIEWED

    Source sequence(s)
    AP000880, AP002853, FP884230

  15. NM_001400609.1 → NP_001387538.1  neural cell adhesion molecule 1 isoform 16 precursor

    Status: REVIEWED

    Source sequence(s)
    AP000880, AP002853, FP884230

  16. NM_001400610.1 → NP_001387539.1  neural cell adhesion molecule 1 isoform 17 precursor

    Status: REVIEWED

    Source sequence(s)
    AP000880, AP002853, FP884230

  17. NM_001400611.1 → NP_001387540.1  neural cell adhesion molecule 1 isoform 18 precursor

    Status: REVIEWED

    Source sequence(s)
    AP000880, FP884230

  18. NM_001400612.1 → NP_001387541.1  neural cell adhesion molecule 1 isoform 19 precursor

    Status: REVIEWED

    Source sequence(s)
    AP000880, AP002853, FP884230

  19. NM_001400613.1 → NP_001387542.1  neural cell adhesion molecule 1 isoform 20 precursor

    Status: REVIEWED

    Source sequence(s)
    AP000880, FP884230

  20. NM_001400614.1 → NP_001387543.1  neural cell adhesion molecule 1 isoform 21 precursor

    Status: REVIEWED

    Source sequence(s)
    AP000880, FP884230

  21. NM_001400615.1 → NP_001387544.1  neural cell adhesion molecule 1 isoform 22 precursor

    Status: REVIEWED

    Source sequence(s)
    AP000880, AP002853, FP884230

  22. NM_001400616.1 → NP_001387545.1  neural cell adhesion molecule 1 isoform 23 precursor

    Status: REVIEWED

    Source sequence(s)
    AP000880, AP002853, FP884230

  23. NM_001400617.1 → NP_001387546.1  neural cell adhesion molecule 1 isoform 24 precursor

    Status: REVIEWED

    Source sequence(s)
    AP000880, AP002853, FP884230

  24. NM_001400618.1 → NP_001387547.1  neural cell adhesion molecule 1 isoform 25 precursor

    Status: REVIEWED

    Source sequence(s)
    AP000880, AP002853, FP884230

  25. NM_001400619.1 → NP_001387548.1  neural cell adhesion molecule 1 isoform 26 precursor

    Status: REVIEWED

    Source sequence(s)
    AP000880, FP884230

  26. NM_001400620.1 → NP_001387549.1  neural cell adhesion molecule 1 isoform 27 precursor

    Status: REVIEWED

    Source sequence(s)
    AP000880, AP002853, FP884230

  27. NM_001400621.1 → NP_001387550.1  neural cell adhesion molecule 1 isoform 28 precursor

    Status: REVIEWED

    Source sequence(s)
    AP000880, AP002853, FP884230

  28. NM_001400622.1 → NP_001387551.1  neural cell adhesion molecule 1 isoform 29 precursor

    Status: REVIEWED

    Source sequence(s)
    AP000880, AP002853, FP884230

  29. NM_001400623.1 → NP_001387552.1  neural cell adhesion molecule 1 isoform 30 precursor

    Status: REVIEWED

    Source sequence(s)
    AP000880, AP002853, FP884230

  30. NM_001400624.1 → NP_001387553.1  neural cell adhesion molecule 1 isoform 31 precursor

    Status: REVIEWED

    Source sequence(s)
    AP000880, AP002853, FP884230

  31. NM_181351.5 → NP_851996.2  neural cell adhesion molecule 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_851996.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 5. The resulting protein (isoform 2) is shorter compared to isoform 5.
    Source sequence(s)
    AK054570, AW131780, BC014205, BC047244, DA337649, S71824
    Consensus CDS
    CCDS73385.1
    UniProtKB/Swiss-Prot
    A8K8T8, P13591, P13592, P13593, Q05C58, Q15829, Q16180, Q16209, Q59FL7, Q86X47, Q96CJ3
    Related
    ENSP00000318472.8, ENST00000316851.12
    Conserved Domains (7) summary
    cd05869
    Location:306 → 412
    IgI_NCAM-1; Immunoglobulin (Ig)-like I-set domain of Neural Cell Adhesion Molecule 1 (NCAM-1)
    smart00410
    Location:124 → 190
    IG_like; Immunoglobulin like
    pfam00041
    Location:613 → 694
    fn3; Fibronectin type III domain
    pfam13927
    Location:421 → 493
    Ig_3; Immunoglobulin domain
    cd00096
    Location:211 → 216
    Ig; Ig strand A [structural motif]
    cd05865
    Location:20 → 116
    IgI_1_NCAM-1; First immunoglobulin (Ig)-like domain of neural cell adhesion molecule (NCAM-1); member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:211 → 307
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    112961420..113278436
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    112971836..113288890
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P13591.3 GenPept UniProtKB/Swiss-Prot:P13591

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