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fwd four wheel drive [ Drosophila melanogaster (fruit fly) ]

Gene ID: 45374, updated on 2-Nov-2024

Summary

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Official Symbol
fwdprovided by FlyBase
Official Full Name
four wheel driveprovided by FlyBase
Primary source
FLYBASE:FBgn0004373
Locus tag
Dmel_CG7004
See related
AllianceGenome:FB:FBgn0004373
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0118547.259; CG7004; Dmel\CG7004; Fwd; PI4K; PI4K3B; PI4KIIIbeta
Summary
Predicted to enable 1-phosphatidylinositol 4-kinase activity. Involved in several processes, including cytoskeleton-dependent cytokinesis; determination of adult lifespan; and spermatogenesis. Located in Golgi apparatus. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness. Orthologous to human PI4KB (phosphatidylinositol 4-kinase beta). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See fwd in Genome Data Viewer
Location:
61C1-61C1; 3-0.5 cM
Exon count:
13
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (305393..319884, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (305393..319884, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene tiny tim 2 Neighboring gene Rho guanine nucleotide exchange factor 3 Neighboring gene deadbeat Neighboring gene uncharacterized protein Neighboring gene Ada2a-containing complex component 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A phospholipid kinase regulates actin organization and intercellular bridge formation during germline cytokinesis. Brill JA, et al. Development, 2000 Sep. PMID 10934029
  2. Frequenin/NCS-1 and the Ca2+-channel alpha1-subunit co-regulate synaptic transmission and nerve-terminal growth. Dason JS, et al. J Cell Sci, 2009 Nov 15. PMID 19861494
  3. Vibrator and PI4KIIIα govern neuroblast polarity by anchoring non-muscle myosin II. Koe CT, et al. Elife, 2018 Feb 27. PMID 29482721, Free PMC Article
  4. Drosophila phosphatidylinositol-4 kinase fwd promotes mitochondrial fission and can suppress Pink1/parkin phenotypes. Terriente-Felix A, et al. PLoS Genet, 2020 Oct. PMID 33085661, Free PMC Article
  5. The class I PITP giotto is required for Drosophila cytokinesis. Giansanti MG, et al. Curr Biol, 2006 Jan 24. PMID 16431372

See all (82) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Drosophila phosphatidylinositol-4 kinase fwd promotes mitochondrial fission and can suppress Pink1/parkin phenotypes.
    Title: Drosophila phosphatidylinositol-4 kinase fwd promotes mitochondrial fission and can suppress Pink1/parkin phenotypes.
  2. dPIP4K activity is a regulator of cell growth and TOR signaling during larval development
    Title: Phosphatidylinositol 5-phosphate 4-kinase (PIP4K) regulates TOR signaling and cell growth during Drosophila development.
  3. data suggest Fwd plays catalytic and noncatalytic roles in regulating Rab11 during cytokinesis
    Title: Dual roles for the Drosophila PI 4-kinase four wheel drive in localizing Rab11 during cytokinesis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 1-phosphatidylinositol 4-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Golgi organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in actomyosin contractile ring contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in male germline ring canal formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in male meiosis cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiosis I cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiosis II cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic spindle organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphatidylinositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in spermatocyte division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
four wheel drive
Names
CG7004-PA
CG7004-PB
CG7004-PC
CG7004-PD
CG7004-PE
Four-wheel drive
fwd-PA
fwd-PB
fwd-PC
fwd-PD
fwd-PE
NP_001261203.1
NP_001356971.1
NP_524822.1
NP_728518.1
NP_728519.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    305393..319884 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001370043.1 → NP_001356971.1  four wheel drive, isoform E [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A4D6K881
    Conserved Domains (1) summary
    cd05168
    Location:1385 → 1674
    PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta

  2. NM_080083.4 → NP_524822.1  four wheel drive, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524822.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q960I2, Q9W0R8
    Related
    FBpp0072416
    Conserved Domains (1) summary
    cd05168
    Location:1385 → 1674
    PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta

  3. NM_167826.2 → NP_728518.1  four wheel drive, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728518.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q960I2, Q9W0R8
    Related
    FBpp0072415
    Conserved Domains (1) summary
    cd05168
    Location:1385 → 1674
    PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta

  4. NM_001274274.1 → NP_001261203.1  four wheel drive, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261203.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q960I2, Q9W0R8
    Conserved Domains (1) summary
    cd05168
    Location:1385 → 1674
    PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta

  5. NM_167827.2 → NP_728519.1  four wheel drive, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728519.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IRJ1, Q9BKJ2
    Related
    FBpp0072417
    Conserved Domains (1) summary
    cd05168
    Location:1049 → 1338
    PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A4D6K881 A0A4D6K881
Q9BKJ2 Q9BKJ2
Q9W0R8 Q9W0R8

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