fhl2b four and a half LIM domains 2b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: fhl2bprovided by ZNC
Official Full Name: four and a half LIM domains 2bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-041010-121
See related: Ensembl:ENSDARG00000003991 AllianceGenome:ZFIN:ZDB-GENE-041010-121
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:103466
Summary: Predicted to enable transcription coregulator activity. Acts upstream of or within skeletal muscle tissue regeneration. Predicted to be active in Z disc and nucleus. Is expressed in cardiovascular system; pigment cell; retina; thymus; and yolk syncytial layer. Orthologous to human FHL2 (four and a half LIM domains 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 6

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (15075793..15101477, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (14948853..14974537, complement)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

fhl2b mediates extraocular muscle protection in zebrafish models of muscular dystrophies and its ectopic expression ameliorates affected body muscles.
Title: fhl2b mediates extraocular muscle protection in zebrafish models of muscular dystrophies and its ectopic expression ameliorates affected body muscles.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transcription coregulator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within skeletal muscle tissue regeneration	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Z disc	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: four and a half LIM domains protein 2b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001006028.2 → NP_001006028.2 four and a half LIM domains protein 2b

Status: PROVISIONAL

Source sequence(s)

CR936426

UniProtKB/TrEMBL

A0A8M1N2Q9, B0V234

Related

ENSDARP00000110234.2, ENSDART00000124132.3

Conserved Domains (3) summary

cd09431
Location:162 → 218

LIM3_Fhl2; The third LIM domain of Four and a half LIM domains protein 2 (FHL2)

cd09433
Location:221 → 278

LIM4_FHL2; The fourth LIM domain of Four and a half LIM domains protein 2 (FHL2)

cl02475
Location:36 → 97

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers