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csrp3 cysteine and glycine-rich protein 3 (cardiac LIM protein) [ Danio rerio (zebrafish) ]

Gene ID: 450005, updated on 2-Nov-2024

Summary

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Official Symbol
csrp3provided by ZNC
Official Full Name
cysteine and glycine-rich protein 3 (cardiac LIM protein)provided by ZNC
Primary source
ZFIN:ZDB-GENE-041010-119
See related
Ensembl:ENSDARG00000101706 AllianceGenome:ZFIN:ZDB-GENE-041010-119
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
csrp3b; zgc:103468
Summary
Predicted to enable actinin binding activity. Predicted to be a structural constituent of muscle. Acts upstream of or within heart contraction; response to muscle stretch; and sarcomere organization. Predicted to be active in Z disc and nucleus. Is expressed in musculature system; pericardial region; and trunk. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; dilated cardiomyopathy 1M; hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 12. Orthologous to human CSRP3 (cysteine and glycine rich protein 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See csrp3 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (16548222..16562204, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (16296249..16310231, complement)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137496159 Neighboring gene metallophosphoesterase domain containing 2a Neighboring gene zinc finger DHHC-type palmitoyltransferase 13 Neighboring gene transfer RNA arginine (anticodon UCG) Neighboring gene transfer RNA arginine (anticodon UCG)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. A novel gene-trap line reveals the dynamic patterns and essential roles of cysteine and glycine-rich protein 3 in zebrafish heart development and regeneration. Liang S, et al. Cell Mol Life Sci, 2024 Mar 31. PMID 38556571, Free PMC Article
  2. Zebrafish cysteine and glycine-rich protein 3 is essential for mechanical stability in skeletal muscles. Chang Y, et al. Biochem Biophys Res Commun, 2019 Apr 9. PMID 30826063
  3. Nexilin mutations destabilize cardiac Z-disks and lead to dilated cardiomyopathy. Hassel D, et al. Nat Med, 2009 Nov. PMID 19881492
  4. In-vivo characterization of human dilated cardiomyopathy genes in zebrafish. Vogel B, et al. Biochem Biophys Res Commun, 2009 Dec 18. PMID 19800866
  5. Zebrafish integrin-linked kinase is required in skeletal muscles for strengthening the integrin-ECM adhesion complex. Postel R, et al. Dev Biol, 2008 Jun 1. PMID 18436206

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A novel gene-trap line reveals the dynamic patterns and essential roles of cysteine and glycine-rich protein 3 in zebrafish heart development and regeneration.
    Title: A novel gene-trap line reveals the dynamic patterns and essential roles of cysteine and glycine-rich protein 3 in zebrafish heart development and regeneration.
  2. csrp3 is dispensable for sarcomere assembly during early muscle development. csrp3 is required for muscle mechanical stability under overloaded stress.
    Title: Zebrafish cysteine and glycine-rich protein 3 is essential for mechanical stability in skeletal muscles.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables actinin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of muscle IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cardiac muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within heart contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in muscle tissue development IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to muscle stretch IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sarcomere organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within sarcomere organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Z disc IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cysteine and glycine-rich protein 3
Names
Muscle LIM protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006026.2 → NP_001006026.2  cysteine and glycine-rich protein 3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' coding region which results in the use of a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    CU041375
    UniProtKB/TrEMBL
    A0A8M1N2S2, F1QJC0
    Related
    ENSDARP00000138514.1, ENSDART00000169093.4
    Conserved Domains (2) summary
    cd09481
    Location:9 → 62
    LIM1_CRP3; The first LIM domain of Cysteine Rich Protein 3 (CRP3/MLP)
    cd09482
    Location:120 → 173
    LIM2_CRP3; The second LIM domain of Cysteine Rich Protein 3 (CRP3/MLP)

  2. NM_001320091.1 → NP_001307020.1  cysteine and glycine-rich protein 3 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer tranascript and encodes the longer isoform (1).
    Source sequence(s)
    CU041375
    UniProtKB/TrEMBL
    A0A8M1P2D0
    Conserved Domains (2) summary
    cd09481
    Location:38 → 91
    LIM1_CRP3; The first LIM domain of Cysteine Rich Protein 3 (CRP3/MLP)
    cd09482
    Location:149 → 202
    LIM2_CRP3; The second LIM domain of Cysteine Rich Protein 3 (CRP3/MLP)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    16548222..16562204 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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