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stmn2a stathmin 2a [ Danio rerio (zebrafish) ]

Gene ID: 449651, updated on 2-Nov-2024

Summary

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Official Symbol
stmn2aprovided by ZNC
Official Full Name
stathmin 2aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-041010-85
See related
Ensembl:ENSDARG00000033234 AllianceGenome:ZFIN:ZDB-GENE-041010-85
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:92905
Summary
Predicted to enable tubulin binding activity. Acts upstream of or within nervous system development. Predicted to be active in cytoplasm and growth cone. Is expressed in gut; head; nervous system; spinal cord neural tube; and trigeminal placode. Orthologous to human STMN2 (stathmin 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See stmn2a in Genome Data Viewer
Location:
chromosome: 16
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (16165029..16182355, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (16257052..16274378, complement)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and IBR domain containing 1b Neighboring gene fatty acid binding protein 4b Neighboring gene uridine phosphorylase 1 Neighboring gene granulito

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Characterization of spatial and temporal expression pattern of SCG10 during zebrafish development. Burzynski GM, et al. Gene Expr Patterns, 2009 Apr. PMID 19272335, Free PMC Article
  2. The Rac-GAP alpha2-Chimaerin Signals via CRMP2 and Stathmins in the Development of the Ocular Motor System. Carretero-Rodriguez L, et al. J Neurosci, 2021 Aug 4. PMID 34168008, Free PMC Article
  3. Stathmin-like 4 is critical for the maintenance of neural progenitor cells in dorsal midbrain of zebrafish larvae. Lin MJ, et al. Sci Rep, 2016 Nov 7. PMID 27819330, Free PMC Article
  4. KBP interacts with SCG10, linking Goldberg-Shprintzen syndrome to microtubule dynamics and neuronal differentiation. Alves MM, et al. Hum Mol Genet, 2010 Sep 15. PMID 20621975, Free PMC Article
  5. Interference with the Cannabinoid Receptor CB1R Results in Miswiring of GnRH3 and AgRP1 Axons in Zebrafish Embryos. Zuccarini G, et al. Int J Mol Sci, 2019 Dec 25. PMID 31881740, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in microtubule depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within nervous system development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of microtubule polymerization or depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of microtubule polymerization or depolymerization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in growth cone IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
stathmin-2a
Names
SCG10b
stathmin-like 2a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005923.2 → NP_001005923.2  stathmin-2a

    Status: VALIDATED

    Source sequence(s)
    BX321920
    UniProtKB/TrEMBL
    A0A8M1N2J6, E7FE68
    Related
    ENSDARP00000094591.3, ENSDART00000103815.4
    Conserved Domains (1) summary
    pfam00836
    Location:43 → 174
    Stathmin; Stathmin family

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    16165029..16182355 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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