U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Hsp70Ab Heat shock protein 70 Ab [ Drosophila melanogaster (fruit fly) ]

Gene ID: 44920, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Hsp70Abprovided by FlyBase
Official Full Name
Heat shock protein 70 Abprovided by FlyBase
Primary source
FLYBASE:FBgn0013276
Locus tag
Dmel_CG18743
See related
AllianceGenome:FB:FBgn0013276
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
87A7 hsp70; CG18743; dhsp70; dHsp70; Dm-hsp70; Dmel\CG18743; DMHSP7A2; GRP78; hs70; hsp 70; Hsp 70; hsp-70; Hsp-70; hsp70; Hsp70; HSP70; hsp70 87A; hsp70(87A); Hsp70-Ab; hsp70a; hsp70A; Hsp70A; hsp70Ab; Hsp70ab; Hsp70aB; HSP70Ab; Hsp70b; HSP70cA2
Summary
Predicted to enable ATP hydrolysis activity; heat shock protein binding activity; and protein folding chaperone. Involved in heat shock-mediated polytene chromosome puffing and response to hypoxia. Predicted to be active in cytoplasm and nucleus. Is expressed in spermatozoon. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Hsp70Ab in Genome Data Viewer
Location:
87A3-87A3; 3-51 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11958535..11960909)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7784257..7786631)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Heat shock protein 70 Aa Neighboring gene uncharacterized protein Neighboring gene aurora A Neighboring gene uncharacterized protein Neighboring gene Glutamate Carrier 1 Neighboring gene Transport and Golgi organization 9

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The carboxyl-terminal repeat domain of RNA polymerase II is not required for transcription factor Sp1 to function in vitro. Zehring WA, et al. J Biol Chem, 1990 May 25. PMID 2187861
  2. The 87A7 chromomere. Identification of novel chromatin structures flanking the heat shock locus that may define the boundaries of higher order domains. Udvardy A, et al. J Mol Biol, 1985 Sep 20. PMID 2997449
  3. Expression of Heat Shock Protein 70 Is Insufficient To Extend Drosophila melanogaster Longevity. Xiao C, et al. G3 (Bethesda), 2019 Dec 3. PMID 31624139, Free PMC Article
  4. Hyperthermic preconditioning of presynaptic calcium regulation in Drosophila. Klose MK, et al. J Neurophysiol, 2008 May. PMID 18272873
  5. Targeting HSP70 to motoneurons protects locomotor activity from hyperthermia in Drosophila. Xiao C, et al. Dev Neurobiol, 2007 Mar. PMID 17443800

See all (523) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data (including data from studies using transgenic animals) suggest that dual enzymatic activity of Fic is, in part, regulated by Fic dimerization, as loss of this dimerization increases AMPylation and reduces deAMPylation of BiP/Grp78. (Fic = Fic domain-containing protein; BiP/Grp78 = molecular chaperone BiP)
    Title: Fic-mediated deAMPylation is not dependent on homodimerization and rescues toxic AMPylation in flies.
  2. All insertions reduced Hsp70A expression below that of a control strain, the magnitude of the reduction was inversely related to the number of nucleotides between the transcription start site and the insertion site.
    Title: Location of P element insertions in the proximal promoter region of Hsp70A is consequential for gene expression and correlated with fecundity in Drosophila melanogaster.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
  
enables heat shock protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein folding chaperone IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in chaperone cofactor-dependent protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in heat shock-mediated polytene chromosome puffing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to heat IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to heat NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in response to hypoxia IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to hypoxia IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to unfolded protein NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
heat shock protein 70 Ab
Names
70 kDa heat shock protein, cytosolic A 2
87A locus
CG18743-PA
Heat-shock-protein-70Ab
Hsp70Ab-PA
heat shock 70
heat shock protein 70
heat shock protein 70Ab
heat-shock protein 70
protein 70

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    11958535..11960909
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_080059.3 → NP_524798.2  heat shock protein 70 Ab [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524798.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P02825, P82910, Q5BI85, Q8MT04, Q95NG7, Q9BIS5
    UniProtKB/TrEMBL
    F3YDI6
    Related
    FBpp0081956
    Conserved Domains (2) summary
    cd10233
    Location:3 → 379
    HSPA1-2_6-8-like_NBD; Nucleotide-binding domain of HSPA1-A, -B, -L, HSPA-2, -6, -7, -8, and similar proteins
    PTZ00009
    Location:2 → 642
    PTZ00009; heat shock 70 kDa protein; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P02825.3 P02825
P82910.2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Miscellaneous