cradd CASP2 and RIPK1 domain containing adaptor with death, gene 1 [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: craddprovided by Xenbase
Official Full Name: CASP2 and RIPK1 domain containing adaptor with death, gene 1provided by Xenbase
Primary source: Xenbase:XB-GENE-5852262
See related: Ensembl:ENSXETG00000025801 AllianceGenome:Xenbase:XB-GENE-5852262
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as: raidd; cradd.1
Summary: Predicted to enable death domain binding activity and protease binding activity. Predicted to act upstream of or within regulation of apoptotic process and signal transduction. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 34. Orthologous to human CRADD (CASP2 and RIPK1 domain containing adaptor with death domain). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information: Annotation category: partial on reference assembly
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Genomic context

Location:: chromosome: 8

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	8	NC_030684.2 (39575838..39579361, complement)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	8	NC_030684.1 (18436405..18440283, complement)

Chromosome 8 - NC_030684.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables death domain binding	IEA Inferred from Electronic Annotation more info
enables protease binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: CASP2 and RIPK1 domain containing adaptor with death, gene 1

Names: CASP2 and RIPK1 domain containing adaptor with death domain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001006910.1 → NP_001006911.1 CASP2 and RIPK1 domain containing adaptor with death, gene 1

See identical proteins and their annotated locations for NP_001006911.1

Status: PROVISIONAL

Source sequence(s)

BC075346

UniProtKB/TrEMBL

F6SJT8, F7A124, G1K3F4, Q6DJ38

Related

ENSXETP00000033446.1, ENSXETT00000033446.3

Conserved Domains (2) summary

cd08319
Location:114 → 196

Death_RAIDD; Death domain of RIP-associated ICH-1 homologous protein with a death domain

cl14633
Location:1 → 93

DD; Death Domain Superfamily of protein-protein interaction domains