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mapk14 mitogen-activated protein kinase 14 [ Xenopus tropicalis (tropical clawed frog) ]

Gene ID: 448296, updated on 4-Nov-2024

Summary

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Official Symbol
mapk14provided by Xenbase
Official Full Name
mitogen-activated protein kinase 14provided by Xenbase
Primary source
Xenbase:XB-GENE-1018617
See related
Ensembl:ENSXETG00000000438 AllianceGenome:Xenbase:XB-GENE-1018617
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus tropicalis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as
rk; p38; csbp; exip; mxi2; csbp1; csbp2; cspb1; sapk2; prkm14; prkm15; sapk2a; p38alpha
Summary
Predicted to enable MAP kinase activity. Predicted to act upstream of or within intracellular signal transduction. Human ortholog(s) of this gene implicated in colon cancer; colorectal carcinoma; nasopharynx carcinoma; and rectum cancer. Orthologous to human MAPK14 (mitogen-activated protein kinase 14). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mapk14 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
13
Annotation release Status Assembly Chr Location
104 current UCB_Xtro_10.0 (GCF_000004195.4) 2 NC_030678.2 (69942227..70045686)
103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 2 NC_030678.1 (61568636..61671349)

Chromosome 2 - NC_030678.2Genomic Context describing neighboring genes Neighboring gene colipase Neighboring gene SRSF protein kinase 1 Neighboring gene zinc finger CCCH-type containing 11A Neighboring gene uncharacterized LOC116408833

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC89076

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within intracellular signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within p38MAPK cascade IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
mitogen-activated protein kinase 14
Names
MAPK p38
NP_001005824.1
XP_012814917.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005824.1 → NP_001005824.1  mitogen-activated protein kinase 14

    See identical proteins and their annotated locations for NP_001005824.1

    Status: PROVISIONAL

    Source sequence(s)
    BC075368
    UniProtKB/TrEMBL
    A0A6I8QBZ2, Q6DJ17
    Related
    ENSXETP00000066026.2, ENSXETT00000073683.2
    Conserved Domains (1) summary
    cd07877
    Location:7 → 351
    STKc_p38alpha; Catalytic domain of the Serine/Threonine Kinase, p38alpha Mitogen-Activated Protein Kinase (also called MAPK14)

RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

  1. NC_030678.2 Reference UCB_Xtro_10.0 Primary Assembly

    Range
    69942227..70045686
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_012959463.3 → XP_012814917.1  mitogen-activated protein kinase 14 isoform X1

    UniProtKB/TrEMBL
    A0A6I8Q7W0, A0A6I8RZ13
    Related
    ENSXETP00000065626.1, ENSXETT00000080234.2
    Conserved Domains (1) summary
    cd07877
    Location:7 → 351
    STKc_p38alpha; Catalytic domain of the Serine/Threonine Kinase, p38alpha Mitogen-Activated Protein Kinase (also called MAPK14)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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