adam9a ADAM metallopeptidase domain 9a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: adam9aprovided by ZNC
Official Full Name: ADAM metallopeptidase domain 9aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040912-127
See related: Ensembl:ENSDARG00000010070 AllianceGenome:ZFIN:ZDB-GENE-040912-127
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: adam9; zgc:101824
Summary: Predicted to enable metalloendopeptidase activity. Predicted to be involved in proteolysis. Predicted to act upstream of or within integrin-mediated signaling pathway. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in cone-rod dystrophy 9. Orthologous to human ADAM9 (ADAM metallopeptidase domain 9). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 8

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (45850137..45939691, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (45842258..45931812, complement)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables metalloendopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metalloendopeptidase activity	IEA Inferred from Electronic Annotation more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within integrin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: disintegrin and metalloproteinase domain-containing protein 9

Names: ADAM metallopeptidase domain 9; a disintegrin and metalloproteinase domain 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004678.1 → NP_001004678.1 disintegrin and metalloproteinase domain-containing protein 9 precursor

See identical proteins and their annotated locations for NP_001004678.1

Status: PROVISIONAL

Source sequence(s)

BC081408

UniProtKB/TrEMBL

Q66IC3

Related

ENSDARP00000040065.5, ENSDART00000040066.7

Conserved Domains (2) summary

pfam01562
Location:51 → 155

Pep_M12B_propep; Reprolysin family propeptide

cl00064
Location:216 → 267

ZnMc; Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which ...