wnt11.S Wnt family member 11 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: wnt11.S
Official Full Name: Wnt family member 11 S homeolog
Primary source: Xenbase:XB-GENE-866540
Locus tag: XELAEV_18016398mg
See related: EnsemblRapid:ENSXLAG00005012551 AllianceGenome:Xenbase:XB-GENE-866540
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: Wnt11r; Xwnt11; wnt11a; Xwnt-11; wnt11-r
Summary: Predicted to enable cytokine activity and frizzled binding activity. Acts upstream of or within several processes, including dorsal fin development; neural crest cell migration; and regulation of signal transduction. Located in extracellular region. Is expressed in anatomical system; mesenchyme; pharyngeal arch; and primary germ layer. Human ortholog(s) of this gene implicated in oral squamous cell carcinoma. Orthologous to human WNT11 (Wnt family member 11). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 2S

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	2S	NC_054374.1 (164161246..164211095)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	2S	NC_030727.1 (154753946..154804562)

Chromosome 2S - NC_054374.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In midgastrula embryos, Wnt5a, Wnt11, and Wnt11b, but not Wnt3a, acted across many cell diameters to orient Prickle3/Vangl2 complexes away from their sources regardless of their positions relative to the body axis.
Title: Wnt proteins can direct planar cell polarity in vertebrate ectoderm.
Because paraxial protocadherin and C-cadherin do not directly interact nor form a joint complex with Fz7, Wnt-11 triggers formation of two distinct complexes that act in parallel to reduce cell adhesion by hampering clustering of C-cadherin.
Title: Wnt-11 and Fz7 reduce cell adhesion in convergent extension by sequestration of PAPC and C-cadherin.
PAR-1 RNA rescues neural cell markers in embryos in which noncanonical Wnt signaling has been blocked. Novel roles for Wnt11R and PAR-1 were identified in neural cell specification. An unexpected connection was shown between morphogenesis and cell fate.
Title: Neural crest specification by noncanonical Wnt signaling and PAR-1.
wnt11r is required in a non-cell-autonomous manner to control neural crest migration.
Title: Wnt11r is required for cranial neural crest migration.
Wnt11-R signaling regulates a calcium sensitive EMT event essential for dorsal fin development of Xenopus.
Title: Wnt11-R signaling regulates a calcium sensitive EMT event essential for dorsal fin development of Xenopus.
Xenopus Wnt11-R is expressed in neural tissue, the brachial arches, and the muscle layer of the heart.
Title: Wnt11-R, a protein closely related to mammalian Wnt11, is required for heart morphogenesis in Xenopus.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables frizzled binding	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell fate commitment	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within dorsal fin development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic axis specification	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within gastrulation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within heart morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
NOT acts_upstream_of_or_within neural crest cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural crest cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within non-canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of JNK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pronephros development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of gastrulation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	TAS Traceable Author Statement more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein Wnt-11

Names: WNT11-related protein; wingless-type MMTV integration site family member 11 S homeolog; wingless-type MMTV integration site family, member 11; wnt11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.