serpine2.L serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: serpine2.L
Official Full Name: serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 L homeolog
Primary source: Xenbase:XB-GENE-947574
Locus tag: XELAEV_18027774mg
See related: EnsemblRapid:ENSXLAG00005017137 AllianceGenome:Xenbase:XB-GENE-947574
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: gdn; pn1; PN-1; xpn-1; serpine2
Summary: Predicted to enable peptidase activity and serine-type endopeptidase inhibitor activity. Predicted to act upstream of or within negative regulation of endopeptidase activity; negative regulation of plasminogen activation; and proteolysis. Predicted to be located in extracellular space. Is expressed in endocrine system; nervous system; pharyngeal arch; and primary germ layer. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human SERPINE2 (serpin family E member 2). [provided by Alliance of Genome Resources, Nov 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 5L

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	5L	NC_054379.1 (132501904..132536464)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	5L	NC_030732.1 (121745412..121779940)

Chromosome 5L - NC_054379.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Inhibition of the serine protease HtrA1 by SerpinE2 suggests an extracellular proteolytic pathway in the control of neural crest migration.
Title: Inhibition of the serine protease HtrA1 by SerpinE2 suggests an extracellular proteolytic pathway in the control of neural crest migration.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of endopeptidase activity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of plasminogen activation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 L homeolog

Names: glia-derived nexin; protease nexin-1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001093520.1 → NP_001086989.1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 L homeolog precursor

See identical proteins and their annotated locations for NP_001086989.1

Status: PROVISIONAL

Source sequence(s)

DQ324047

UniProtKB/TrEMBL

A0A974CWZ1, Q0P032

Related

ENSXLAP00005050555.1, ENSXLAT00005051696.1

Conserved Domains (1) summary

cd02051
Location:20 → 395

PAI-1_nexin-1; Plasminogen activator inhibitor-1_like. Plasminogen activator inhibitor-1 (PAI-1) is the primary, fast-acting inhibitor of plasminogen activators. It is often bound to vitronectin, an abundant component of the extracellular matrix in many tissues. ...

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054379.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

132501904..132536464

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_018261971.2 → XP_018117460.1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 L homeolog isoform X1

UniProtKB/TrEMBL

A0A974CWZ1, Q0P032