U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

matn3a matrilin 3a [ Danio rerio (zebrafish) ]

Gene ID: 445503, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
matn3aprovided by ZNC
Official Full Name
matrilin 3aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040822-21
See related
Ensembl:ENSDARG00000069245 AllianceGenome:ZFIN:ZDB-GENE-040822-21
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ns:zf-e359; zgc:101120; si:dkeyp-50f7.4
Summary
Predicted to be active in collagen-containing extracellular matrix. Is expressed in notochord; skeletal system; and vertebra. Human ortholog(s) of this gene implicated in multiple epiphyseal dysplasia 5; osteoarthritis; and osteochondrodysplasia. Orthologous to human MATN3 (matrilin 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See matn3a in Genome Data Viewer
Location:
chromosome: 20
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (43760062..43775544, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (43862984..43878668, complement)

Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene zona pellucida protein AX 1 Neighboring gene matrilin-3-like Neighboring gene tetratricopeptide repeat domain 32 Neighboring gene lysosomal protein transmembrane 4 alpha Neighboring gene MAP/microtubule affinity-regulating kinase 3b Neighboring gene uncharacterized LOC137488693

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Characterization of recombinantly expressed matrilin VWA domains. Becker AK, et al. Protein Expr Purif, 2015 Mar. PMID 25462806, Free PMC Article
  2. Reciprocal gene loss between Tetraodon and zebrafish after whole genome duplication in their ancestor. Sémon M, et al. Trends Genet, 2007 Mar. PMID 17275132
  3. Zebrafish (Danio rerio) matrilins: shared and divergent characteristics with their mammalian counterparts. Ko YP, et al. Biochem J, 2005 Mar 1. PMID 15588228, Free PMC Article
  4. The mechanisms underlying the developmental effects of bisphenol F on zebrafish. Mu X, et al. Sci Total Environ, 2019 Oct 15. PMID 31412491
  5. Dysregulatory effects of retinoic acid isomers in late zebrafish embryos. Navarro-Martín L, et al. Environ Sci Pollut Res Int, 2018 Feb. PMID 29178002

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by ZFIN

Component Evidence Code Pubs
is_active_in collagen-containing extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
matrilin-3a

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004007.2 → NP_001004007.1  matrilin-3a isoform 1 precursor

    See identical proteins and their annotated locations for NP_001004007.1

    Status: VALIDATED

    Source sequence(s)
    BX649436
    UniProtKB/TrEMBL
    A2CEG0, Q68EK6
    Related
    ENSDARP00000125091.1, ENSDART00000148809.3
    Conserved Domains (2) summary
    pfam10393
    Location:292 → 334
    Matrilin_ccoil; Trimeric coiled-coil oligomerization domain of matrilin
    cl00057
    Location:61 → 282
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  2. NM_001328273.1 → NP_001315202.1  matrilin-3a isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    BX649436
    UniProtKB/TrEMBL
    A0A8M1PA40, F1QH94
    Related
    ENSDARP00000124655.1, ENSDART00000149001.3
    Conserved Domains (1) summary
    cl00057
    Location:61 → 290
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007131.7 Reference GRCz11 Primary Assembly

    Range
    43760062..43775544 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017352468.3 → XP_017207957.1  matrilin-3a isoform X1

    UniProtKB/TrEMBL
    A2CEG0, Q68EK6
    Conserved Domains (2) summary
    pfam10393
    Location:292 → 334
    Matrilin_ccoil; Trimeric coiled-coil oligomerization domain of matrilin
    cl00057
    Location:61 → 282
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools