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ndc80 NDC80 kinetochore complex component [ Danio rerio (zebrafish) ]

Gene ID: 445386, updated on 12-Sep-2024

Summary

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Official Symbol
ndc80provided by ZNC
Official Full Name
NDC80 kinetochore complex componentprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-904
See related
Ensembl:ENSDARG00000071694 AllianceGenome:ZFIN:ZDB-GENE-030131-904
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
kntc2l; wu:fb52e02; zgc:111801
Summary
Predicted to be involved in attachment of mitotic spindle microtubules to kinetochore; mitotic spindle organization; and positive regulation of mitotic cell cycle spindle assembly checkpoint. Predicted to act upstream of or within cell division. Predicted to be located in kinetochore. Predicted to be part of Ndc80 complex. Is expressed in proliferative region. Orthologous to human NDC80 (NDC80 kinetochore complex component). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See ndc80 in Genome Data Viewer
Location:
chromosome: 12
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (10353366..10365969, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (10315523..10328126, complement)

Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene peptide YYb Neighboring gene terminal uridylyl transferase 1, U6 snRNA-specific Neighboring gene marker of proliferation Ki-67 Neighboring gene eukaryotic elongation factor 2 kinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Time Course Analysis of Gene Expression Patterns in Zebrafish Eye During Optic Nerve Regeneration. McCurley AT, et al. J Exp Neurosci, 2010 Jul 13. PMID 20740047, Free PMC Article
  2. Identification of 315 genes essential for early zebrafish development. Amsterdam A, et al. Proc Natl Acad Sci U S A, 2004 Aug 31. PMID 15256591, Free PMC Article
  3. Contrasted innate responses to two viruses in zebrafish: insights into the ancestral repertoire of vertebrate IFN-stimulated genes. Briolat V, et al. J Immunol, 2014 May 1. PMID 24683187
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables kinetochore adaptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables microtubule binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in attachment of mitotic spindle microtubules to kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within attachment of mitotic spindle microtubules to kinetochore IEA
Inferred from Electronic Annotation
more info
  
involved_in attachment of mitotic spindle microtubules to kinetochore ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome segregation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in metaphase chromosome alignment ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitotic sister chromatid biorientation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitotic spindle organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of mitotic cell cycle spindle assembly checkpoint ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of Ndc80 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Ndc80 complex IEA
Inferred from Electronic Annotation
more info
  
part_of Ndc80 complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
located_in kinetochore IEA
Inferred from Electronic Annotation
more info
  
located_in kinetochore ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
kinetochore protein NDC80 homolog
Names
HEC (highly expressed in cancer)
NDC80 homolog, kinetochore complex component
kinetochore protein Hec1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003863.1 → NP_001003863.1  kinetochore protein NDC80 homolog

    See identical proteins and their annotated locations for NP_001003863.1

    Status: PROVISIONAL

    Source sequence(s)
    AY648762
    UniProtKB/Swiss-Prot
    Q502U1, Q6DRJ7
    Related
    ENSDARP00000012236.6, ENSDART00000007335.8
    Conserved Domains (2) summary
    pfam03801
    Location:49 → 203
    Ndc80_HEC; HEC/Ndc80p family
    cl23720
    Location:270 → 377
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007123.7 Reference GRCz11 Primary Assembly

    Range
    10353366..10365969 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6DRJ7.1 GenPept UniProtKB/Swiss-Prot:Q6DRJ7

Gene LinkOut

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