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aqp4 aquaporin 4 [ Danio rerio (zebrafish) ]

Gene ID: 445293, updated on 2-Nov-2024

Summary

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Official Symbol
aqp4provided by ZNC
Official Full Name
aquaporin 4provided by ZNC
Primary source
ZFIN:ZDB-GENE-040724-152
See related
Ensembl:ENSDARG00000010565 AllianceGenome:ZFIN:ZDB-GENE-040724-152
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:100922; si:ch211-192k9.1
Summary
This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. This protein is found in the sensory cells of several organs in zebrafish, suggesting a role in the regulation of water balance and ion transport in the sensory organs. A recent study provided evidence for translation readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Nov 2017]
Orthologs
human mouse all
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Genomic context

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See aqp4 in Genome Data Viewer
Location:
chromosome: 20
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (18163368..18190005)
105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (18263785..18290455)

Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC137488634 Neighboring gene uncharacterized LOC110438169 Neighboring gene potassium channel tetramerization domain containing 1 Neighboring gene TAF4B RNA polymerase II, TATA box binding protein (TBP)-associated factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Aquaporin 4 in the sensory organs of adult zebrafish (Danio rerio). Zichichi R, et al. Brain Res, 2011 Apr 12. PMID 21334314
  2. Astroglial structures in the zebrafish brain. Grupp L, et al. J Comp Neurol, 2010 Nov 1. PMID 20853506
  3. Expression analysis of the aquaporins during zebrafish embryonic development. Qin Y, et al. Gene Expr Patterns, 2019 Jun. PMID 30951885
  4. Aquaporin 1 Is Involved in Acid Secretion by Ionocytes of Zebrafish Embryos through Facilitating CO2 Transport. Horng JL, et al. PLoS One, 2015. PMID 26287615, Free PMC Article
  5. Live-imaging of astrocyte morphogenesis and function in zebrafish neural circuits. Chen J, et al. Nat Neurosci, 2020 Oct. PMID 32895565, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables channel activity IEA
Inferred from Electronic Annotation
more info
  
enables water channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables water transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in water transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within water transport IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sarcolemma IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
aquaporin-4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003749.4 → NP_001003749.1  aquaporin-4 isoform 1

    See identical proteins and their annotated locations for NP_001003749.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes two isoforms that result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UAG termination codon. This RefSeq represents the shorter isoform (1).
    Source sequence(s)
    AL954739
    UniProtKB/TrEMBL
    D3TZY2, Q6AZD2
    Related
    ENSDARP00000021578.5, ENSDART00000011287.7
    Conserved Domains (1) summary
    pfam00230
    Location:32 → 250
    MIP; Major intrinsic protein

  2. NM_001358313.1 → NP_001345242.1  aquaporin-4 isoform 1x

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes two isoforms that result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UAG termination codon. This RefSeq represents the longer, C-terminally extended isoform (1x). As the UGA stop codon has been reported to specify several alternative amino acids (tryptophan, cysteine, arginine and serine), its location in the longer isoform is denoted by an 'X'.
    Source sequence(s)
    AL954739
    Conserved Domains (2) summary
    pfam00230
    Location:32 → 250
    MIP; Major intrinsic protein
    pfam05300
    Location:290 → 345
    DUF737; Protein of unknown function (DUF737)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007131.7 Reference GRCz11 Primary Assembly

    Range
    18163368..18190005
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009294620.4 → XP_009292895.1  aquaporin-4 isoform X1

    UniProtKB/TrEMBL
    A0A2R8Q5A8, A0A8M3AW39
    Related
    ENSDARP00000148057.1, ENSDART00000186507.1
    Conserved Domains (1) summary
    pfam00230
    Location:40 → 258
    MIP; Major intrinsic protein
Nucleotide Protein Strain
Heading Accession and Version

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