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Eml5 EMAP like 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 444982, updated on 18-Sep-2024

Summary

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Official Symbol
Eml5provided by RGD
Official Full Name
EMAP like 5provided by RGD
Primary source
RGD:1303275
See related
EnsemblRapid:ENSRNOG00000004207 AllianceGenome:RGD:1303275
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable microtubule binding activity. Predicted to be located in cytoplasm and microtubule. Orthologous to human EML5 (EMAP like 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 153.9), Adrenal (RPKM 94.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Eml5 in Genome Data Viewer
Location:
6q32
Exon count:
46
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (123775269..123905585, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (118046655..118175831, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (122768939..122898046, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase, non-receptor type 21 Neighboring gene uncharacterized LOC134479245 Neighboring gene zinc finger CCCH type containing 14 Neighboring gene tetratricopeptide repeat domain 8 Neighboring gene uncharacterized LOC134479463 Neighboring gene candidate plasticity gene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Eml5, a novel WD40 domain protein expressed in rat brain. O'Connor V, et al. Gene, 2004 Jul 7. PMID 15225882
  2. Expression levels of NPPB, ITGB6, CPNE4, EML5, and ITSN1 in fresh exudates swabbed from critically colonised and infected full-thickness wounds in rats. Takizawa C, et al. Int Wound J, 2023 Apr. PMID 36307995, Free PMC Article
  3. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Expression levels of NPPB, ITGB6, CPNE4, EML5, and ITSN1 in fresh exudates swabbed from critically colonised and infected full-thickness wounds in rats.
    Title: Expression levels of NPPB, ITGB6, CPNE4, EML5, and ITSN1 in fresh exudates swabbed from critically colonised and infected full-thickness wounds in rats.
  2. Eml5 may play a role in the regulation of cytoskeletal rearrangements during neuronal development and in adult brain.
    Title: Eml5, a novel WD40 domain protein expressed in rat brain.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
echinoderm microtubule-associated protein-like 5
Names
EMAP-5
EMAP-like protein 5
echinoderm microtubule associated protein like 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003402.2 → NP_001003402.2  echinoderm microtubule-associated protein-like 5

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/Swiss-Prot
    Q6ED65
    Related
    ENSRNOP00000093290.2, ENSRNOT00000096031.2
    Conserved Domains (4) summary
    COG2319
    Location:720 → 1140
    WD40; WD40 repeat [General function prediction only]
    pfam03451
    Location:5 → 47
    HELP; HELP motif
    sd00039
    Location:730 → 769
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:725 → 1063
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    123775269..123905585 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063262251.1 → XP_063118321.1  echinoderm microtubule-associated protein-like 5 isoform X4

    UniProtKB/Swiss-Prot
    Q6ED65

  2. XM_063262249.1 → XP_063118319.1  echinoderm microtubule-associated protein-like 5 isoform X2

    UniProtKB/Swiss-Prot
    Q6ED65
    Related
    ENSRNOP00000054411.6, ENSRNOT00000057601.7

  3. XM_063262250.1 → XP_063118320.1  echinoderm microtubule-associated protein-like 5 isoform X3

    UniProtKB/Swiss-Prot
    Q6ED65

  4. XM_063262248.1 → XP_063118318.1  echinoderm microtubule-associated protein-like 5 isoform X1

    UniProtKB/Swiss-Prot
    Q6ED65

  5. XM_063262255.1 → XP_063118325.1  echinoderm microtubule-associated protein-like 5 isoform X8

    UniProtKB/TrEMBL
    A0A8I6GK80

  6. XM_063262258.1 → XP_063118328.1  echinoderm microtubule-associated protein-like 5 isoform X11

  7. XM_063262259.1 → XP_063118329.1  echinoderm microtubule-associated protein-like 5 isoform X12

  8. XM_063262253.1 → XP_063118323.1  echinoderm microtubule-associated protein-like 5 isoform X6

    UniProtKB/Swiss-Prot
    Q6ED65

  9. XM_063262252.1 → XP_063118322.1  echinoderm microtubule-associated protein-like 5 isoform X5

    UniProtKB/Swiss-Prot
    Q6ED65

  10. XM_063262254.1 → XP_063118324.1  echinoderm microtubule-associated protein-like 5 isoform X7

    UniProtKB/Swiss-Prot
    Q6ED65

  11. XM_063262256.1 → XP_063118326.1  echinoderm microtubule-associated protein-like 5 isoform X9

  12. XM_063262257.1 → XP_063118327.1  echinoderm microtubule-associated protein-like 5 isoform X10

  13. XM_063262260.1 → XP_063118330.1  echinoderm microtubule-associated protein-like 5 isoform X13

    UniProtKB/TrEMBL
    A6JEF3

RNA

  1. XR_010052132.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ED65.2 GenPept UniProtKB/Swiss-Prot:Q6ED65

Gene LinkOut

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