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ear ENL/AF9-related [ Drosophila melanogaster (fruit fly) ]

Gene ID: 44451, updated on 2-Nov-2024

Summary

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Official Symbol
earprovided by FlyBase
Official Full Name
ENL/AF9-relatedprovided by FlyBase
Primary source
FLYBASE:FBgn0026441
Locus tag
Dmel_CG4913
See related
AllianceGenome:FB:FBgn0026441
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4913; dENL/AF9; Dmel\CG4913; Ear; ENL; ENL/AF-9; ENL/AF9; TFIIF
Summary
Predicted to enable histone binding activity. Predicted to be involved in chromatin remodeling; regulation of transcription by RNA polymerase II; and transcription initiation at RNA polymerase II promoter. Part of super elongation complex. Is expressed in organism. Orthologous to human MLLT1 (MLLT1 super elongation complex subunit) and MLLT3 (MLLT3 super elongation complex subunit). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See ear in Genome Data Viewer
Location:
88F1-88F1; 3-57 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15320756..15325279)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11146478..11151001)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene easter

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Multifaceted roles of YEATS domain-containing proteins and novel links to neurological diseases. Yeewa R, et al. Cell Mol Life Sci, 2022 Mar 12. PMID 35279775, Free PMC Article
  2. The H3K79me3 methyl-transferase Grappa is involved in the establishment and thermal plasticity of abdominal pigmentation in Drosophila melanogaster females. Narbey R, et al. Sci Rep, 2024 Apr 25. PMID 38664546, Free PMC Article
  3. The human leukemic oncogene MLL-AF4 promotes hyperplastic growth of hematopoietic tissues in Drosophila larvae. Johannessen JA, et al. iScience, 2023 Oct 20. PMID 37720104, Free PMC Article
  4. Transcript level is a key factor affecting RNAi efficiency. Chen J, et al. Pestic Biochem Physiol, 2021 Jul. PMID 34119217
  5. AF9 YEATS domain links histone acetylation to DOT1L-mediated H3K79 methylation. Li Y, et al. Cell, 2014 Oct 23. PMID 25417107, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription initiation at RNA polymerase II promoter ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
part_of NuA4 histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of super elongation complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of transcription factor TFIID complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
ENL/AF9-related
Names
CG4913-PA
CG4913-PB
CG4913-PC
ear-PA
ear-PB
ear-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    15320756..15325279
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001275667.1 → NP_001262596.1  ENL/AF9-related, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262596.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IHH1, Q9VF92
    Conserved Domains (1) summary
    pfam03366
    Location:27 → 107
    YEATS; YEATS family

  2. NM_143722.3 → NP_651979.1  ENL/AF9-related, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651979.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IHH1, Q9VF92
    Related
    FBpp0082538
    Conserved Domains (1) summary
    pfam03366
    Location:27 → 107
    YEATS; YEATS family

  3. NM_001275666.1 → NP_001262595.1  ENL/AF9-related, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262595.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KG69, Q8IHH1
    Conserved Domains (1) summary
    pfam03366
    Location:27 → 107
    YEATS; YEATS family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KG69 A0A0B4KG69
Q8IHH1 Q8IHH1
Q8MRJ5 Q8MRJ5
Q9VF92 Q9VF92

Gene LinkOut

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