babam2.L BRISC and BRCA1 A complex member 2 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: babam2.L
Official Full Name: BRISC and BRCA1 A complex member 2 L homeolog
Primary source: Xenbase:XB-GENE-1032926
Locus tag: XELAEV_18026341mg
See related: EnsemblRapid:ENSXLAG00005034199 AllianceGenome:Xenbase:XB-GENE-1032926
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: bre; bre.L; babam2
Summary: Predicted to enable polyubiquitin modification-dependent protein binding activity. Predicted to act upstream of or within several processes, including mitotic G2 DNA damage checkpoint signaling; positive regulation of DNA repair; and response to ionizing radiation. Predicted to be located in cytoplasm and nucleus. Predicted to be part of BRCA1-A complex and BRISC complex. Orthologous to human BABAM2 (BRISC and BRCA1 A complex member 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 5L

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	5L	NC_054379.1 (20394690..20521183, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	5L	NC_030732.1 (19720559..19847291, complement)

Chromosome 5L - NC_054379.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables polyubiquitin modification-dependent protein binding	IEA Inferred from Electronic Annotation more info
enables polyubiquitin modification-dependent protein binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA repair	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within double-strand break repair	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within double-strand break repair	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within mitotic G2 DNA damage checkpoint signaling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitotic G2 DNA damage checkpoint signaling	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of DNA repair	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of DNA repair	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within response to ionizing radiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to ionizing radiation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of BRCA1-A complex	IEA Inferred from Electronic Annotation more info
part_of BRCA1-A complex	ISS Inferred from Sequence or Structural Similarity more info
part_of BRISC complex	IEA Inferred from Electronic Annotation more info
part_of BRISC complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: BRISC and BRCA1-A complex member 2

Names: BRCA1-A complex subunit BRE; BRCA1/BRCA2-containing complex subunit 45; Brain and reproductive organ-expressed protein; brain and reproductive organ-expressed (TNFRSF1A modulator) L homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001092182.1 → NP_001085651.1 BRISC and BRCA1-A complex member 2

See identical proteins and their annotated locations for NP_001085651.1

Status: PROVISIONAL

Source sequence(s)

BC073095

UniProtKB/Swiss-Prot

Q6GPL9

UniProtKB/TrEMBL

A0A974CVF4

Related

ENSXLAP00005102315.1, ENSXLAT00005104310.1

Conserved Domains (1) summary

pfam06113
Location:8 → 334

BRE; Brain and reproductive organ-expressed protein (BRE)

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054379.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

20394690..20521183 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)