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MSI1 musashi RNA binding protein 1 [ Homo sapiens (human) ]

Gene ID: 4440, updated on 3-Nov-2024

Summary

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Official Symbol
MSI1provided by HGNC
Official Full Name
musashi RNA binding protein 1provided by HGNC
Primary source
HGNC:HGNC:7330
See related
Ensembl:ENSG00000135097 MIM:603328; AllianceGenome:HGNC:7330
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a protein containing two conserved tandem RNA recognition motifs. Similar proteins in other species function as RNA-binding proteins and play central roles in posttranscriptional gene regulation. Expression of this gene has been correlated with the grade of the malignancy and proliferative activity in gliomas and melanomas. A pseudogene for this gene is located on chromosome 11q13. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 2.5), brain (RPKM 2.0) and 14 other tissues See more
Orthologs
mouse all
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Genomic context

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See MSI1 in Genome Data Viewer
Location:
12q24.31
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (120339662..120369164, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (120326839..120356341, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (120779133..120806967, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene sirtuin 4 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:120752165-120752348 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:120753363-120754138 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7138 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7139 Neighboring gene RNA, U6 small nuclear 1088, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7140 Neighboring gene phospholipase A2 group IB Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7141 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:120794238-120794738 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120796175-120796787 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120796788-120797399 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:120798696-120799414 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120799415-120800132 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:120803530-120803720 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:120814267-120814767 Neighboring gene ribosomal protein S27 pseudogene 25 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4949 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7142 Neighboring gene Sharpr-MPRA regulatory region 12947 Neighboring gene MPRA-validated peak2004 silencer Neighboring gene MPRA-validated peak2005 silencer Neighboring gene MPRA-validated peak2007 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:120876089-120876610 Neighboring gene uncharacterized LOC124903126 Neighboring gene cytochrome c oxidase subunit 6A1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Cancer stem cell marker Musashi-1 rs2522137 genotype is associated with an increased risk of lung cancer. Wang X, et al. PLoS One, 2014. PMID 24787949, Free PMC Article
  2. Density of Musashi‑1‑positive stem cells in the stomach of patients with irritable bowel syndrome. El-Salhy M, et al. Mol Med Rep, 2020 Oct. PMID 32945509, Free PMC Article
  3. The RNA-binding protein Musashi1 affects medulloblastoma growth via a network of cancer-related genes and is an indicator of poor prognosis. Vo DT, et al. Am J Pathol, 2012 Nov. PMID 22985791, Free PMC Article
  4. The expression patterns of Msi1 related with the glioma grade and the cytoplasmic Msi1 promotes angiogenesis. Song X, et al. Tissue Cell, 2013 Feb. PMID 23017339
  5. The effects of Hedgehog on the RNA-binding protein Msi1 in the proliferation and apoptosis of mesenchymal stem cells. Hong IS, et al. PLoS One, 2013. PMID 23418578, Free PMC Article

See all (151) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Msi1 promotes breast cancer metastasis by regulating invadopodia-mediated extracellular matrix degradation via the Timp3-Mmp9 pathway.
    Title: Msi1 promotes breast cancer metastasis by regulating invadopodia-mediated extracellular matrix degradation via the Timp3-Mmp9 pathway.
  2. Exosomal Circ_FMN2 Derived from the Serum of Colorectal Cancer Patients Promotes Cancer Progression by miR-338-3p/MSI1 Axis.
    Title: Exosomal Circ_FMN2 Derived from the Serum of Colorectal Cancer Patients Promotes Cancer Progression by miR-338-3p/MSI1 Axis.
  3. Short C-terminal Musashi-1 proteins regulate pluripotency states in embryonic stem cells.
    Title: Short C-terminal Musashi-1 proteins regulate pluripotency states in embryonic stem cells.
  4. Dysregulated Stem Cell Markers Musashi-1 and Musashi-2 are Associated with Therapy Resistance in Inflammatory Breast Cancer.
    Title: Dysregulated Stem Cell Markers Musashi-1 and Musashi-2 are Associated with Therapy Resistance in Inflammatory Breast Cancer.
  5. The oncogene Musashi1 encodes novel miRNAs in breast cancer.
    Title: The oncogene Musashi1 encodes novel miRNAs in breast cancer.
  6. Increased expression of musashi 1 on breast cancer cells has implication to understand dormancy and survival in bone marrow.
    Title: Increased expression of musashi 1 on breast cancer cells has implication to understand dormancy and survival in bone marrow.
  7. Zika virus RNA structure controls its unique neurotropism by bipartite binding to Musashi-1.
    Title: Zika virus RNA structure controls its unique neurotropism by bipartite binding to Musashi-1.
  8. Theoretical studies on RNA recognition by Musashi 1 RNA-binding protein.
    Title: Theoretical studies on RNA recognition by Musashi 1 RNA-binding protein.
  9. The RNA-Binding Protein Musashi1 Regulates a Network of Cell Cycle Genes in Group 4 Medulloblastoma.
    Title: The RNA-Binding Protein Musashi1 Regulates a Network of Cell Cycle Genes in Group 4 Medulloblastoma.
  10. Immunolocalization of stem/progenitor cell biomarkers Oct-4, C-kit and Musashi-1 in endometriotic lesions.
    Title: Immunolocalization of stem/progenitor cell biomarkers Oct-4, C-kit and Musashi-1 in endometriotic lesions.
Submit: New GeneRIF Correction See all GeneRIFs (98)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular condensate scaffold activity IEA
Inferred from Electronic Annotation
more info
  
enables poly(U) RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in central nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in epithelial cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in nervous system development TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to hormone IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
RNA-binding protein Musashi homolog 1
Names
musashi-1
musashi1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001414485.1 → NP_001401414.1  RNA-binding protein Musashi homolog 1 isoform b

    Status: REVIEWED

    Source sequence(s)
    AC003982

  2. NM_001414486.1 → NP_001401415.1  RNA-binding protein Musashi homolog 1 isoform c

    Status: REVIEWED

    Source sequence(s)
    AC003982

  3. NM_001414487.1 → NP_001401416.1  RNA-binding protein Musashi homolog 1 isoform d

    Status: REVIEWED

    Source sequence(s)
    AC003982

  4. NM_001414488.1 → NP_001401417.1  RNA-binding protein Musashi homolog 1 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC003982

  5. NM_001414489.1 → NP_001401418.1  RNA-binding protein Musashi homolog 1 isoform f

    Status: REVIEWED

    Source sequence(s)
    AC003982

  6. NM_001414490.1 → NP_001401419.1  RNA-binding protein Musashi homolog 1 isoform g

    Status: REVIEWED

    Source sequence(s)
    AC003982

  7. NM_001414491.1 → NP_001401420.1  RNA-binding protein Musashi homolog 1 isoform h

    Status: REVIEWED

    Source sequence(s)
    AC003982

  8. NM_001414492.1 → NP_001401421.1  RNA-binding protein Musashi homolog 1 isoform i

    Status: REVIEWED

    Source sequence(s)
    AC003982
    Related
    ENSP00000446710.1, ENST00000546985.1

  9. NM_001414493.1 → NP_001401422.1  RNA-binding protein Musashi homolog 1 isoform j

    Status: REVIEWED

    Source sequence(s)
    AC003982

  10. NM_001414494.1 → NP_001401423.1  RNA-binding protein Musashi homolog 1 isoform j

    Status: REVIEWED

    Source sequence(s)
    AC003982

  11. NM_001414495.1 → NP_001401424.1  RNA-binding protein Musashi homolog 1 isoform j

    Status: REVIEWED

    Source sequence(s)
    AC003982

  12. NM_001414496.1 → NP_001401425.1  RNA-binding protein Musashi homolog 1 isoform k

    Status: REVIEWED

    Source sequence(s)
    AC003982

  13. NM_001414497.1 → NP_001401426.1  RNA-binding protein Musashi homolog 1 isoform l

    Status: REVIEWED

    Source sequence(s)
    AC003982

  14. NM_001414498.1 → NP_001401427.1  RNA-binding protein Musashi homolog 1 isoform l

    Status: REVIEWED

    Source sequence(s)
    AC003982

  15. NM_002442.4 → NP_002433.1  RNA-binding protein Musashi homolog 1 isoform a

    See identical proteins and their annotated locations for NP_002433.1

    Status: REVIEWED

    Source sequence(s)
    AB012851, AC003982, AI583233, BX393884
    Consensus CDS
    CCDS9196.1
    UniProtKB/Swiss-Prot
    O43347, Q96PU0, Q96PU1, Q96PU2, Q96PU3
    Related
    ENSP00000257552.2, ENST00000257552.7
    Conserved Domains (3) summary
    TIGR01628
    Location:32 → 339
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12323
    Location:110 → 183
    RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    cd12576
    Location:21 → 96
    RRM1_MSI; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    120339662..120369164 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011538361.4 → XP_011536663.1  RNA-binding protein Musashi homolog 1 isoform X1

    See identical proteins and their annotated locations for XP_011536663.1

    UniProtKB/Swiss-Prot
    O43347, Q96PU0, Q96PU1, Q96PU2, Q96PU3
    Conserved Domains (3) summary
    TIGR01628
    Location:32 → 339
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12323
    Location:110 → 183
    RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins
    cd12576
    Location:21 → 96
    RRM1_MSI; RNA recognition motif 1 (RRM1) found in RNA-binding protein Musashi homolog Musashi-1, Musashi-2 and similar proteins

  2. XM_047428872.1 → XP_047284828.1  RNA-binding protein Musashi homolog 1 isoform X4

  3. XM_011538366.3 → XP_011536668.1  RNA-binding protein Musashi homolog 1 isoform X3

    See identical proteins and their annotated locations for XP_011536668.1

    Conserved Domains (2) summary
    TIGR01628
    Location:8 → 236
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12323
    Location:7 → 80
    RRM2_MSI; RNA recognition motif 2 (RRM2) found in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins

  4. XM_011538364.3 → XP_011536666.1  RNA-binding protein Musashi homolog 1 isoform X2

    Conserved Domains (2) summary
    COG0724
    Location:8 → 87
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12323
    Location:10 → 83
    RRM2_MSI; RNA recognition motif 2 in RNA-binding protein Musashi homologs Musashi-1, Musashi-2 and similar proteins

  5. XM_006719404.4 → XP_006719467.1  RNA-binding protein Musashi homolog 1 isoform X5

    See identical proteins and their annotated locations for XP_006719467.1

    UniProtKB/TrEMBL
    B3KN16
    Conserved Domains (2) summary
    TIGR01628
    Location:2 → 201
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cl17169
    Location:1 → 45
    RRM_SF; RNA recognition motif (RRM) superfamily

  6. XM_011538371.3 → XP_011536673.1  RNA-binding protein Musashi homolog 1 isoform X5

    See identical proteins and their annotated locations for XP_011536673.1

    UniProtKB/TrEMBL
    B3KN16
    Conserved Domains (2) summary
    TIGR01628
    Location:2 → 201
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cl17169
    Location:1 → 45
    RRM_SF; RNA recognition motif (RRM) superfamily

  7. XM_011538368.3 → XP_011536670.1  RNA-binding protein Musashi homolog 1 isoform X5

    See identical proteins and their annotated locations for XP_011536670.1

    UniProtKB/TrEMBL
    B3KN16
    Conserved Domains (2) summary
    TIGR01628
    Location:2 → 201
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cl17169
    Location:1 → 45
    RRM_SF; RNA recognition motif (RRM) superfamily

  8. XM_011538370.3 → XP_011536672.1  RNA-binding protein Musashi homolog 1 isoform X5

    See identical proteins and their annotated locations for XP_011536672.1

    UniProtKB/TrEMBL
    B3KN16
    Conserved Domains (2) summary
    TIGR01628
    Location:2 → 201
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cl17169
    Location:1 → 45
    RRM_SF; RNA recognition motif (RRM) superfamily

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    120326839..120356341 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054372081.1 → XP_054228056.1  RNA-binding protein Musashi homolog 1 isoform X1

    UniProtKB/Swiss-Prot
    O43347, Q96PU0, Q96PU1, Q96PU2, Q96PU3

  2. XM_054372084.1 → XP_054228059.1  RNA-binding protein Musashi homolog 1 isoform X4

  3. XM_054372083.1 → XP_054228058.1  RNA-binding protein Musashi homolog 1 isoform X3

  4. XM_054372082.1 → XP_054228057.1  RNA-binding protein Musashi homolog 1 isoform X2

  5. XM_054372085.1 → XP_054228060.1  RNA-binding protein Musashi homolog 1 isoform X5

  6. XM_054372087.1 → XP_054228062.1  RNA-binding protein Musashi homolog 1 isoform X5

  7. XM_054372086.1 → XP_054228061.1  RNA-binding protein Musashi homolog 1 isoform X5

  8. XM_054372088.1 → XP_054228063.1  RNA-binding protein Musashi homolog 1 isoform X5

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O43347.1 GenPept UniProtKB/Swiss-Prot:O43347

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