ppp1cb.L protein phosphatase 1, catalytic subunit, beta isozyme L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: ppp1cb.L
Official Full Name: protein phosphatase 1, catalytic subunit, beta isozyme L homeolog
Primary source: Xenbase:XB-GENE-961676
Locus tag: XELAEV_18026335mg
See related: EnsemblRapid:ENSXLAG00005034791 AllianceGenome:Xenbase:XB-GENE-961676
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: ppp1cb; ppp1cb.S
Summary: Predicted to enable myosin-light-chain-phosphatase activity. Predicted to act upstream of or within regulation of cell adhesion. Predicted to be located in cytoplasm and nucleus. Predicted to be part of PTW/PP1 phosphatase complex. Human ortholog(s) of this gene implicated in Noonan syndrome-like disorder with loose anagen hair 2. Orthologous to human PPP1CB (protein phosphatase 1 catalytic subunit beta). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 5L

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	5L	NC_054379.1 (20154572..20196160, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	5L	NC_030732.1 (19479686..19521365, complement)

Chromosome 5L - NC_054379.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables myosin-light-chain-phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within circadian regulation of gene expression	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glycogen metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of circadian rhythm	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of PTW/PP1 phosphatase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: serine/threonine-protein phosphatase PP1-beta catalytic subunit

Names: PP-1B; protein phosphatase 1, catalytic subunit, beta isozyme S homeolog

NP_001085426.1

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001091957.1 → NP_001085426.1 serine/threonine-protein phosphatase PP1-beta catalytic subunit

See identical proteins and their annotated locations for NP_001085426.1

Status: PROVISIONAL

Source sequence(s)

BC072730

UniProtKB/Swiss-Prot

Q6GQL2

UniProtKB/TrEMBL

A0A974CPW5

Related

ENSXLAP00005104210.1, ENSXLAT00005106229.1

Conserved Domains (1) summary

cd07414
Location:7 → 297

MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054379.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

20154572..20196160 complement

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GenBank, FASTA, Sequence Viewer (Graphics)