AANAT aralkylamine N-acetyltransferase [Ovis aries (sheep)] - Gene

Summary

Gene symbol: AANAT
Gene description: aralkylamine N-acetyltransferase
See related: EnsemblRapid:ENSOARG00020014913
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Ovis aries
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
Also known as: SNAT; AA-NAT
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Genomic context

Location:: chromosome: 11

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	ARS-UI_Ramb_v3.0 (GCF_016772045.2)	11	NC_056064.1 (54628621..54630556, complement)

Chromosome 11 - NC_056064.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_056064.1 Chromosome 11 Reference ARS-UI_Ramb_v3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Our study proves that IL-1beta suppresses melatonin secretion and its action seems to be targeted on the reduction of pineal AA-NAT protein expression
Title: Interleukin-1 β Modulates Melatonin Secretion in Ovine Pineal Gland: Ex Vivo Study.
These results support that serotonin N-Acetyltransferase phosphorylation is not sufficient for complex formation with 14-3-3, as structurally constrained anchor residues play a critical function in stabilizing the protein-protein interaction.
Title: Structurally constrained residues outside the binding motif are essential in the interaction of 14-3-3 and phosphorylated partner.
structural kink and local rigidity imposed by Pro-64 may enhance activity by favoring configurations of Loop 1 that facilitate catalysis and do not become immobilized by intramolecular interactions
Title: Evidence that proline focuses movement of the floppy loop of arylalkylamine N-acetyltransferase (EC 2.3.1.87).

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables aralkylamine N-acetyltransferase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in circadian rhythm	IEA Inferred from Electronic Annotation more info	PubMed
involved_in melatonin biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in response to light stimulus	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: serotonin N-acetyltransferase

Names: arylalkylamine N-acetyltransferase; pineal serotonin N-acetyltransferase; serotonin acetylase

NP_001009461.1

EC 2.3.1.87

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001009461.1 → NP_001009461.1 serotonin N-acetyltransferase

See identical proteins and their annotated locations for NP_001009461.1

Status: PROVISIONAL

Source sequence(s)

U29663

UniProtKB/Swiss-Prot

Q29495

UniProtKB/TrEMBL

M4MEU5, W5PB64

Related

ENSOARP00020018976.1, ENSOART00020022881.2

Conserved Domains (1) summary

cl17182
Location:36 → 183

NAT_SF; N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate