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KITLG KIT ligand [ Ovis aries (sheep) ]

Gene ID: 443371, updated on 10-Oct-2024

Summary

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Gene symbol
KITLG
Gene description
KIT ligand
See related
EnsemblRapid:ENSOARG00020008140
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Ovis aries
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
Also known as
MGF; SCF
Orthologs
human mouse all
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Genomic context

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See KITLG in Genome Data Viewer
Location:
chromosome: 3
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) 3 NC_056056.1 (124761391..124868193, complement)

Chromosome 3 - NC_056056.1Genomic Context describing neighboring genes Neighboring gene centrosomal protein 290 Neighboring gene transmembrane O-mannosyltransferase targeting cadherins 3 Neighboring gene transfer RNA arginine (anticodon UCU) Neighboring gene transfer RNA glycine (anticodon CCC) Neighboring gene uncharacterized LOC132659610

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_056056.1 Chromosome 3 Reference ARS-UI_Ramb_v3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Skipping of exons by premature termination of transcription and alternative splicing within intron-5 of the sheep SCF gene: a novel splice variant. Saravanaperumal SA, et al. PLoS One, 2012. PMID 22719917, Free PMC Article
  2. The cloning and expression of the cDNA for ovine stem cell factor (kit-ligand) and characterization of its in vitro haematopoietic activity. McInnes CJ, et al. Cytokine, 1999 Apr. PMID 10328863
  3. Expression of the ovine stem cell factor gene during folliculogenesis in late fetal and adult ovaries. Tisdall DJ, et al. J Mol Endocrinol, 1997 Apr. PMID 9134499
  4. Ovine stem cell factor gene is located within a syntenic group on chromosome 3 conserved across mammalian species. Tisdall DJ, et al. Mamm Genome, 1996 Jun. PMID 8662240
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables stem cell factor receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
kit ligand
Names
c-Kit ligand
mast cell growth factor
stem cell factor
NP_001254817.1
XP_012015104.2
XP_012015112.2
XP_012015125.2
XP_060267594.1
XP_060267595.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001267888.1 → NP_001254817.1  kit ligand precursor

    See identical proteins and their annotated locations for NP_001254817.1

    Status: PROVISIONAL

    Source sequence(s)
    GU386374
    UniProtKB/TrEMBL
    A0A6P3CXZ5, G8Z9W6
    Conserved Domains (1) summary
    pfam02404
    Location:1 → 174
    SCF; Stem cell factor

RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UI_Ramb_v3.0 Primary Assembly

Genomic

  1. NC_056056.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Range
    124761391..124868193 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_012159735.4 → XP_012015125.2  kit ligand isoform X3

    UniProtKB/Swiss-Prot
    P79368, Q28591

  2. XM_012159714.4 → XP_012015104.2  kit ligand isoform X1

    UniProtKB/Swiss-Prot
    P79368, Q28591
    Related
    ENSOARP00020010485.2, ENSOART00020012737.2

  3. XM_012159722.5 → XP_012015112.2  kit ligand isoform X2

    UniProtKB/TrEMBL
    A0A836A7Q3, G8Z9W4
    Related
    ENSOARP00020050120.1, ENSOART00020050779.1

  4. XM_060411612.1 → XP_060267595.1  kit ligand isoform X4

    Related
    ENSOARP00020041078.1, ENSOART00020058287.1

  5. XM_060411611.1 → XP_060267594.1  kit ligand isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P79368.2 GenPept UniProtKB/Swiss-Prot:P79368

Gene LinkOut

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Molecular Biology Databases
Research Materials