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CTSD cathepsin D [ Ovis aries (sheep) ]

Gene ID: 443060, updated on 10-Oct-2024

Summary

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Gene symbol
CTSD
Gene description
cathepsin D
See related
EnsemblRapid:ENSOARG00020009289
Gene type
protein coding
RefSeq status
MODEL
Organism
Ovis aries
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
Orthologs
human mouse all
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Genomic context

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See CTSD in Genome Data Viewer
Location:
chromosome: 21
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) 21 NC_056074.1 (46088585..46097887)

Chromosome 21 - NC_056074.1Genomic Context describing neighboring genes Neighboring gene troponin I2, fast skeletal type Neighboring gene synaptotagmin 8 Neighboring gene uncharacterized LOC121817483 Neighboring gene interferon induced transmembrane protein 10 Neighboring gene uncharacterized LOC121817488 Neighboring gene KAP5.4 keratin protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_056074.1 Chromosome 21 Reference ARS-UI_Ramb_v3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A mutation in the ovine cathepsin D gene causes a congenital lysosomal storage disease with profound neurodegeneration. Tyynelä J, et al. EMBO J, 2000 Jun 15. PMID 10856224, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables aspartic-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
cathepsin D
Names
lysosomal aspartyl protease

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UI_Ramb_v3.0 Primary Assembly

Genomic

  1. NC_056074.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Range
    46088585..46097887
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_027959254.2 → XP_027815055.1  cathepsin D isoform X2

    UniProtKB/Swiss-Prot
    Q9MZS8
    Related
    ENSOARP00020011805.2, ENSOART00020014314.2

  2. XM_042237763.2 → XP_042093697.2  cathepsin D isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9MZS8.1 GenPept UniProtKB/Swiss-Prot:Q9MZS8

Gene LinkOut

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