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ZNF727 zinc finger protein 727 [ Homo sapiens (human) ]

Gene ID: 442319, updated on 2-Nov-2024

Summary

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Official Symbol
ZNF727provided by HGNC
Official Full Name
zinc finger protein 727provided by HGNC
Primary source
HGNC:HGNC:22785
See related
Ensembl:ENSG00000214652 AllianceGenome:HGNC:22785
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF727P
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in thyroid (RPKM 2.3), ovary (RPKM 1.5) and 21 other tissues See more
Orthologs
all
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Genomic context

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See ZNF727 in Genome Data Viewer
Location:
7q11.21
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (64045434..64085339)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (65253324..65293248)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (63505812..63545717)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1005 Neighboring gene uncharacterized LOC105375317 Neighboring gene tripartite motif containing 60 pseudogene 17 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:63560238-63560738 Neighboring gene GUSB pseudogene 6 Neighboring gene MT-ND4L pseudogene 2 Neighboring gene MT-ND4 pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Zinc fingers function cooperatively with KRAB domain for nuclear localization of KRAB-containing zinc finger proteins. Wang W, et al. PLoS One, 2014. PMID 24647005, Free PMC Article
  2. Evolution of KRAB-containing zinc finger proteins and their roles in species evolution. Wang J, et al. Yi Chuan, 2016 Nov 20. PMID 27867147
  3. Cys2His2 zinc finger protein family: classification, functions, and major members. Razin SV, et al. Biochemistry (Mosc), 2012 Mar. PMID 22803940
  4. A Chemical Proteomics Approach to Reveal Direct Protein-Protein Interactions in Living Cells. Kleiner RE, et al. Cell Chem Biol, 2018 Jan 18. PMID 29104064, Free PMC Article
  5. The DNA sequence of human chromosome 7. Hillier LW, et al. Nature, 2003 Jul 10. PMID 12853948

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative zinc finger protein 727
Names
zinc finger protein 727 pseudogene

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159522.3 → NP_001152994.1  putative zinc finger protein 727

    See identical proteins and their annotated locations for NP_001152994.1

    Status: VALIDATED

    Source sequence(s)
    AC115220, DA235663
    Consensus CDS
    CCDS55113.1
    UniProtKB/Swiss-Prot
    A8MUV8
    Related
    ENSP00000485448.1, ENST00000456806.3
    Conserved Domains (6) summary
    smart00349
    Location:4 → 64
    KRAB; krueppel associated box
    COG5048
    Location:296 → 465
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:392 → 477
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:286 → 306
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:148 → 167
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:270 → 295
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    64045434..64085339
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017012225.3 → XP_016867714.1  putative zinc finger protein 727 isoform X1

RNA

  1. XR_242241.4 RNA Sequence

  2. XR_927469.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    65253324..65293248
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054358264.1 → XP_054214239.1  putative zinc finger protein 727 isoform X1

RNA

  1. XR_008487617.1 RNA Sequence

  2. XR_008487618.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_011772.1: Suppressed sequence

    Description
    NG_011772.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A8MUV8.3 GenPept UniProtKB/Swiss-Prot:A8MUV8

Gene LinkOut

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