BECN2 beclin 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: BECN2provided by HGNC
Official Full Name: beclin 2provided by HGNC
Primary source: HGNC:HGNC:38606
See related: Ensembl:ENSG00000196289 MIM:615687; AllianceGenome:HGNC:38606
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: BECN1L1; BECN1P1
Summary: Predicted to enable phosphatidylinositol 3-kinase binding activity and protein-macromolecule adaptor activity. Acts upstream of or within G protein-coupled receptor catabolic process; autophagy; and endosome to lysosome transport. Predicted to be located in cytoplasm. Predicted to be part of phosphatidylinositol 3-kinase complex, class III, type I and phosphatidylinositol 3-kinase complex, class III, type II. Predicted to be active in phagophore assembly site. [provided by Alliance of Genome Resources, Oct 2024]
Orthologs: mouse all
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Genomic context

Location:: 1q43

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (241957767..241959062)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (241369811..241371106)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (242121069..242122364)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Beclin 2 negatively regulates innate immune signaling and tumor development.
Title: Beclin 2 negatively regulates innate immune signaling and tumor development.
Further data showed that reactive oxygen species-c-Jun activation by HBx resulted in the release of beclin-1 from its association with beclin-2 to form a complex with VPS34, thus enhancing autophagosome formation.
Title: Reactive Oxygen Species-Mediated c-Jun NH(2)-Terminal Kinase Activation Contributes to Hepatitis B Virus X Protein-Induced Autophagy via Regulation of the Beclin-1/Bcl-2 Interaction.
polar BECN2 CCD interface residues result in a metastable homodimer, facilitating dissociation, but enable better interactions with polar ATG14 residues stabilizing the BECN2:ATG14 heterodimer.
Title: BECN2 interacts with ATG14 through a metastable coiled-coil to mediate autophagy.
Both transfected and endogenous beclin 2 coimmunoprecipitated with vGPCR. Beclin 2 overexpression decreased HA-vGPCR steady-state levels. It regulates vGPCR levels by a lysosomal degradation pathway.
Title: Endolysosomal trafficking of viral G protein-coupled receptor functions in innate immunity and control of viral oncogenesis.
distinct patterns of Beclin 1 and Beclin 2 were associated with aggressive clinical outcomes. Beclin 1 overexpression, as well as Beclin 2 overexpression and depletion, contributed to tumor growth.
Title: Expression of Beclin Family Proteins Is Associated with Tumor Progression in Oral Cancer.
Study identified a previously uncharacterized mammalian-specific protein, Beclin 2, which, like Beclin 1, functions in autophagy and interacts with class III PI3K complex components.[Beclin 2]
Title: Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables phosphatidylinositol 3-kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-macromolecule adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within G protein-coupled receptor catabolic process	IPI Inferred from Physical Interaction more info	PubMed
involved_in autophagosome assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to nitrogen starvation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within endosome to lysosome transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endosome to lysosome transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in late endosome to vacuole transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitophagy	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in phagophore assembly site	IBA Inferred from Biological aspect of Ancestor more info
part_of phosphatidylinositol 3-kinase complex, class III, type I	IBA Inferred from Biological aspect of Ancestor more info
part_of phosphatidylinositol 3-kinase complex, class III, type II	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: beclin-2

Names: Beclin-1-like protein 1; beclin-1 autophagy-related pseudogene 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001290693.1 → NP_001277622.1 beclin-2

See identical proteins and their annotated locations for NP_001277622.1

Status: VALIDATED

Source sequence(s)

HM031116

Consensus CDS

CCDS81433.1

UniProtKB/Swiss-Prot

A8MW95, E9KNW0

Related

ENSP00000488361.1, ENST00000419583.2

Conserved Domains (1) summary

pfam04111
Location:116 → 428

APG6; Autophagy protein Apg6

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

241957767..241959062

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

NC_060925.1 Alternate T2T-CHM13v2.0

Range

241369811..241371106

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NG_022940.1: Suppressed sequence

Description

NG_022940.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.