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fus fusilli [ Drosophila melanogaster (fruit fly) ]

Gene ID: 44095, updated on 2-Nov-2024

Summary

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Official Symbol
fusprovided by FlyBase
Official Full Name
fusilliprovided by FlyBase
Primary source
FLYBASE:FBgn0023441
Locus tag
Dmel_CG8205
See related
AllianceGenome:FB:FBgn0023441
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
cg8205; CG8205; Dmel\CG8205; E(cact[E10])7; Fus; FUS
Summary
Enables mRNA binding activity. Involved in regulation of RNA splicing. Predicted to be located in nucleus. Predicted to be part of ribonucleoprotein complex. Predicted to be active in nucleoplasm. Is expressed in several structures, including adult head; dorsal ectoderm; germ layer; gut section; and visceral mesoderm derivative. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 109. Orthologous to human ESRP1 (epithelial splicing regulatory protein 1) and ESRP2 (epithelial splicing regulatory protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See fus in Genome Data Viewer
Location:
52B3-52B5; 2-75 cM
Exon count:
15
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (15657318..15676669, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11544823..11564174, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mir-278 stem loop Neighboring gene antisense RNA:CR45143 Neighboring gene Vacuolar H[+] ATPase 14kD subunit 1 Neighboring gene GDP-mannose pyrophosphorylase A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Alternative splicing regulates distinct subcellular localization of Epithelial splicing regulatory protein 1 (Esrp1) isoforms. Yang Y, et al. Sci Rep, 2017 Jun 20. PMID 28634384, Free PMC Article
  2. Drosha-dependent microRNAs modulate FUS-mediated neurodegeneration in vivo. Kour S, et al. Nucleic Acids Res, 2023 Nov 10. PMID 37791873, Free PMC Article
  3. Self-assembly of FUS through its low-complexity domain contributes to neurodegeneration. Matsumoto T, et al. Hum Mol Genet, 2018 Apr 15. PMID 29425337
  4. Molecular Dissection of FUS Points at Synergistic Effect of Low-Complexity Domains in Toxicity. Bogaert E, et al. Cell Rep, 2018 Jul 17. PMID 30021151, Free PMC Article
  5. IN VITRO AND IN VIVO MODELS OF AMYOTROPHIC LATERAL SCLEROSIS: AN UPDATED OVERVIEW. Gois AM, et al. Brain Res Bull, 2020 Jun. PMID 32247802

See all (63) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Drosha-dependent microRNAs modulate FUS-mediated neurodegeneration in vivo.
    Title: Drosha-dependent microRNAs modulate FUS-mediated neurodegeneration in vivo.
  2. C9orf72-associated arginine-rich dipeptide repeats induce RNA-dependent nuclear accumulation of Staufen in neurons.
    Title: C9orf72-associated arginine-rich dipeptide repeats induce RNA-dependent nuclear accumulation of Staufen in neurons.
  3. Caz is a Drosophila homologue of FUS, which is one of the genes causing amyotrophic lateral sclerosis (ALS). The novel roles for Caz and Aub demonstrated herein using the Caz-knockdown fly will contribute to a deeper understanding of the pathogenesis of ALS.
    Title: Novel roles of Drosophila FUS and Aub responsible for piRNA biogenesis in neuronal disorders.
  4. arginine residues in the C-terminal low-complexity domain are also required for maturation of FUS in cellular stress granules.
    Title: Molecular Dissection of FUS Points at Synergistic Effect of Low-Complexity Domains in Toxicity.
  5. Self-assembly of FUS through its low-complexity domain contributes to neurodegeneration in frontotemporal dementia-amyotrophic lateral sclerosis Drosophila model.
    Title: Self-assembly of FUS through its low-complexity domain contributes to neurodegeneration.
  6. Using a Drosophila model of FUS-ALS, we corroborate that induction of autophagy significantly increases survival.
    Title: Isogenic FUS-eGFP iPSC Reporter Lines Enable Quantification of FUS Stress Granule Pathology that Is Rescued by Drugs Inducing Autophagy.
  7. data show that mitochondrial impairment is a critical early event in FUS proteinopathy, and provide insights into the pathogenic mechanism of FUS-induced neurodegeneration.
    Title: FUS interacts with ATP synthase beta subunit and induces mitochondrial unfolded protein response in cellular and animal models.
  8. Our data indicate that PINK1 and Parkin play an important role in FUS-induced neurodegeneration. This study has uncovered a previously unknown link between FUS proteinopathy and PINK1/Parkin genes, providing new insights into the pathogenesis of FUS proteinopathy.
    Title: PINK1 and Parkin are genetic modifiers for FUS-induced neurodegeneration.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of RNA splicing IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
fusilli
Names
CG8205-PA
CG8205-PB
CG8205-PC
CG8205-PD
CG8205-PE
CG8205-PF
CG8205-PG
CG8205-PH
enhancer of cactus[E10], number 7
fus-PA
fus-PB
fus-PC
fus-PD
fus-PE
fus-PF
fus-PG
fus-PH

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    15657318..15676669 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_166105.3 → NP_725479.1  fusilli, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725479.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C5WLM9
    Related
    FBpp0086478
    Conserved Domains (4) summary
    cd12738
    Location:280 → 359
    RRM1_Fusilli; RNA recognition motif 1 in Drosophila RNA-binding protein Fusilli and similar proteins
    cd12741
    Location:363 → 462
    RRM2_Fusilli; RNA recognition motif 2 in Drosophila RNA-binding protein Fusilli and similar proteins
    cd12743
    Location:545 → 629
    RRM3_Fusilli; RNA recognition motif 3 in Drosophila RNA-binding protein Fusilli and similar proteins
    cl10012
    Location:13 → 194
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily

  2. NM_001169690.1 → NP_001163161.1  fusilli, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163161.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C5WLM9, E1JH76
    Conserved Domains (4) summary
    cd12738
    Location:280 → 359
    RRM1_Fusilli; RNA recognition motif 1 in Drosophila RNA-binding protein Fusilli and similar proteins
    cd12741
    Location:363 → 462
    RRM2_Fusilli; RNA recognition motif 2 in Drosophila RNA-binding protein Fusilli and similar proteins
    cd12743
    Location:514 → 598
    RRM3_Fusilli; RNA recognition motif 3 in Drosophila RNA-binding protein Fusilli and similar proteins
    cl10012
    Location:13 → 194
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily

  3. NM_001259418.2 → NP_001246347.1  fusilli, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246347.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K880
    Conserved Domains (3) summary
    cd12741
    Location:29 → 128
    RRM2_Fusilli; RNA recognition motif 2 in Drosophila RNA-binding protein Fusilli and similar proteins
    cd12743
    Location:180 → 264
    RRM3_Fusilli; RNA recognition motif 3 in Drosophila RNA-binding protein Fusilli and similar proteins
    cl17169
    Location:1 → 25
    RRM_SF; RNA recognition motif (RRM) superfamily

  4. NM_166106.3 → NP_725480.1  fusilli, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725480.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9BJZ5
    Related
    FBpp0086481
    Conserved Domains (3) summary
    cd12741
    Location:29 → 128
    RRM2_Fusilli; RNA recognition motif 2 in Drosophila RNA-binding protein Fusilli and similar proteins
    cd12743
    Location:211 → 295
    RRM3_Fusilli; RNA recognition motif 3 in Drosophila RNA-binding protein Fusilli and similar proteins
    cl17169
    Location:1 → 25
    RRM_SF; RNA recognition motif (RRM) superfamily

  5. NM_166108.3 → NP_725482.1  fusilli, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725482.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A1ZA30, A1ZA31, Q1EBX1, Q7JR39, Q960H4, Q9BJZ5
    UniProtKB/TrEMBL
    E2QCE8
    Related
    FBpp0086476
    Conserved Domains (4) summary
    cd12738
    Location:280 → 359
    RRM1_Fusilli; RNA recognition motif 1 in Drosophila RNA-binding protein Fusilli and similar proteins
    cd12741
    Location:363 → 462
    RRM2_Fusilli; RNA recognition motif 2 in Drosophila RNA-binding protein Fusilli and similar proteins
    cd12743
    Location:545 → 629
    RRM3_Fusilli; RNA recognition motif 3 in Drosophila RNA-binding protein Fusilli and similar proteins
    cl10012
    Location:13 → 194
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily

  6. NM_079952.4 → NP_524691.1  fusilli, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524691.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A1ZA30, A1ZA31, Q1EBX1, Q7JR39, Q960H4, Q9BJZ5
    UniProtKB/TrEMBL
    E2QCE8
    Related
    FBpp0086477
    Conserved Domains (4) summary
    cd12738
    Location:280 → 359
    RRM1_Fusilli; RNA recognition motif 1 in Drosophila RNA-binding protein Fusilli and similar proteins
    cd12741
    Location:363 → 462
    RRM2_Fusilli; RNA recognition motif 2 in Drosophila RNA-binding protein Fusilli and similar proteins
    cd12743
    Location:545 → 629
    RRM3_Fusilli; RNA recognition motif 3 in Drosophila RNA-binding protein Fusilli and similar proteins
    cl10012
    Location:13 → 194
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily

  7. NM_166107.2 → NP_725481.1  fusilli, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725481.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A1ZA30, A1ZA31, Q1EBX1, Q7JR39, Q960H4, Q9BJZ5
    UniProtKB/TrEMBL
    E2QCE8
    Related
    FBpp0086479
    Conserved Domains (4) summary
    cd12738
    Location:280 → 359
    RRM1_Fusilli; RNA recognition motif 1 in Drosophila RNA-binding protein Fusilli and similar proteins
    cd12741
    Location:363 → 462
    RRM2_Fusilli; RNA recognition motif 2 in Drosophila RNA-binding protein Fusilli and similar proteins
    cd12743
    Location:545 → 629
    RRM3_Fusilli; RNA recognition motif 3 in Drosophila RNA-binding protein Fusilli and similar proteins
    cl10012
    Location:13 → 194
    DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily

  8. NM_166109.2 → NP_725483.1  fusilli, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725483.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9BJZ5
    Related
    FBpp0086480
    Conserved Domains (3) summary
    cd12741
    Location:29 → 128
    RRM2_Fusilli; RNA recognition motif 2 in Drosophila RNA-binding protein Fusilli and similar proteins
    cd12743
    Location:211 → 295
    RRM3_Fusilli; RNA recognition motif 3 in Drosophila RNA-binding protein Fusilli and similar proteins
    cl17169
    Location:1 → 25
    RRM_SF; RNA recognition motif (RRM) superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4K880 A0A0B4K880
E1JH76 E1JH76
E2QCE8 E2QCE8
Q9BJZ5.1 Q9BJZ5

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