U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

KLK12 kallikrein related peptidase 12 [ Homo sapiens (human) ]

Gene ID: 43849, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
KLK12provided by HGNC
Official Full Name
kallikrein related peptidase 12provided by HGNC
Primary source
HGNC:HGNC:6360
See related
Ensembl:ENSG00000186474 MIM:605539; AllianceGenome:HGNC:6360
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KLKL5; KLK-L5
Summary
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Expression
Biased expression in esophagus (RPKM 4.6), salivary gland (RPKM 1.0) and 4 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See KLK12 in Genome Data Viewer
Location:
19q13.41
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (51029094..51035002, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (54117609..54123558, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (51532350..51538258, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene kallikrein related peptidase 10 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:51528951-51529509 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:51529510-51530067 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:51530627-51531183 Neighboring gene kallikrein related peptidase 11 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:51533216-51533447 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:51541373-51541873 Neighboring gene kallikrein related peptidase 13 Neighboring gene kallikrein related peptidase 14

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Prognostic value of kallikrein-related peptidase 12 (KLK12) mRNA expression in triple-negative breast cancer patients. Gong W, et al. Mol Med, 2020 Feb 7. PMID 32028882, Free PMC Article
  2. Knockdown of KLK12 inhibits viability and induces apoptosis in human colorectal cancer HT-29 cell line. Li Q, et al. Int J Mol Med, 2019 Nov. PMID 31485623, Free PMC Article
  3. Human kallikrein-related peptidase 12 (KLK12) splice variants discriminate benign from cancerous breast tumors. Papachristopoulou G, et al. Clin Biochem, 2018 Aug. PMID 29807016
  4. Kallikrein 12 downregulation reduces AGS gastric cancer cell proliferation and migration. Li XS, et al. Genet Mol Res, 2016 Aug 29. PMID 27706634
  5. KLK12 is a novel serine protease and a new member of the human kallikrein gene family-differential expression in breast cancer. Yousef GM, et al. Genomics, 2000 Nov 1. PMID 11056051

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Prognostic value of kallikrein-related peptidase 12 (KLK12) mRNA expression in triple-negative breast cancer patients.
    Title: Prognostic value of kallikrein-related peptidase 12 (KLK12) mRNA expression in triple-negative breast cancer patients.
  2. KLK12 was overexpressed in colorectal cancer.
    Title: Knockdown of KLK12 inhibits viability and induces apoptosis in human colorectal cancer HT-29 cell line.
  3. novel KLK11 and KLK12 splice variants represent new potential cancer biomarkers
    Title: Novel splice variants of the human kallikrein-related peptidases 11 (KLK11) and 12 (KLK12), unraveled by next-generation sequencing technology.
  4. results demonstrate the discriminative value of KLK12sv1/2 and KLK12sv3 between benign and malignant breast tumors as well as their potential favorable prognostic significance in breast adenocarcinoma.
    Title: Human kallikrein-related peptidase 12 (KLK12) splice variants discriminate benign from cancerous breast tumors.
  5. KLK12 gene silencing reduces gastric cancer cell proliferation and migration.
    Title: Kallikrein 12 downregulation reduces AGS gastric cancer cell proliferation and migration.
  6. Data indicate that the KLK12 SNP rs3865443 was not associated with tumor aggressiveness but showed marginal association with prostate cancer risk for the rare homozygote.
    Title: Common variation in Kallikrein genes KLK5, KLK6, KLK12, and KLK13 and risk of prostate cancer and tumor aggressiveness.
  7. KLK12 gene is markedly overexpressed in gastric cancer
    Title: Clinical significance of human kallikrein 12 gene expression in gastric cancer.
  8. Kallikrein 5 and kallikrein 12 cleave human influenza hemagglutinins and activate thrombolytic zymogens.
    Title: Cleavage activation of human-adapted influenza virus subtypes by kallikrein-related peptidases 5 and 12.
  9. the proangiogenic activity of KLK12 in lung endothelial cells was not related to a kinin release
    Title: Pro-angiogenic effect of human kallikrein-related peptidase 12 (KLK12) in lung endothelial cells does not depend on kinin-mediated activation of B2 receptor.
  10. Results suggest that kallikrein-related peptidase 12 (KLK12) splice variant KLK12sv3 can be regarded as a marker of good prognosis in breast cancer.
    Title: Human kallikrein-related peptidase 12 (KLK12) splice variants expression in breast cancer and their clinical impact.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2021-02-02)

ClinGen Genome Curation Page
Haploinsufficency

Dosage sensitivity unlikely (Last evaluated 2021-02-02)

ClinGen Genome Curation PagePubMed

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

Go to the top of the page Help

Replication interactions

Interaction Pubs
Knockdown of kallikrein-related peptidase 12 (KLK12) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC42603, DKFZp686H1078

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables peptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables serine-type peptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein maturation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region TAS
Traceable Author Statement
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in secretory granule IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
kallikrein-12
Names
kallikrein-like protein 5

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001370125.1 → NP_001357054.1  kallikrein-12 isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AC011473
    Consensus CDS
    CCDS12821.1
    UniProtKB/Swiss-Prot
    Q9UKR0, Q9UKR1, Q9UKR2
    UniProtKB/TrEMBL
    A0A024R4M4
    Related
    ENSP00000508282.1, ENST00000684732.1
    Conserved Domains (1) summary
    cd00190
    Location:22 → 244
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  2. NM_001370126.1 → NP_001357055.1  kallikrein-12 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC011473
    UniProtKB/TrEMBL
    A8MQ31, Q49AM7
    Conserved Domains (1) summary
    cl27237
    Location:37 → 126
    Trypsin

  3. NM_001370127.1 → NP_001357056.1  kallikrein-12 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC011473
    Consensus CDS
    CCDS54298.1
    UniProtKB/TrEMBL
    B9EGA9
    Conserved Domains (1) summary
    smart00020
    Location:37 → 131
    Tryp_SPc; Trypsin-like serine protease

  4. NM_001370128.1 → NP_001357057.1  kallikrein-12 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC011473
    Consensus CDS
    CCDS54298.1
    UniProtKB/TrEMBL
    B9EGA9
    Conserved Domains (1) summary
    smart00020
    Location:37 → 131
    Tryp_SPc; Trypsin-like serine protease

  5. NM_019598.3 → NP_062544.1  kallikrein-12 isoform 1 precursor

    See identical proteins and their annotated locations for NP_062544.1

    Status: REVIEWED

    Source sequence(s)
    AC011473
    Consensus CDS
    CCDS12820.1
    UniProtKB/Swiss-Prot
    Q9UKR0
    Related
    ENSP00000250351.4, ENST00000250351.4
    Conserved Domains (2) summary
    smart00020
    Location:21 → 236
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:22 → 236
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  6. NM_145894.2 → NP_665901.1  kallikrein-12 isoform 2 precursor

    See identical proteins and their annotated locations for NP_665901.1

    Status: REVIEWED

    Source sequence(s)
    AC011473
    Consensus CDS
    CCDS12821.1
    UniProtKB/Swiss-Prot
    Q9UKR0, Q9UKR1, Q9UKR2
    UniProtKB/TrEMBL
    A0A024R4M4
    Related
    ENSP00000324181.4, ENST00000319590.8
    Conserved Domains (1) summary
    cd00190
    Location:22 → 244
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  7. NM_145895.2 → NP_665902.2  kallikrein-12 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC011473
    Consensus CDS
    CCDS54298.1
    UniProtKB/TrEMBL
    B9EGA9
    Conserved Domains (1) summary
    smart00020
    Location:37 → 131
    Tryp_SPc; Trypsin-like serine protease

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    51029094..51035002 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    54117609..54123558 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UKR0.1 GenPept UniProtKB/Swiss-Prot:Q9UKR0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous