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NfI Nuclear factor I [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43782, updated on 2-Nov-2024

Summary

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Official Symbol
NfIprovided by FlyBase
Official Full Name
Nuclear factor Iprovided by FlyBase
Primary source
FLYBASE:FBgn0042696
Locus tag
Dmel_CG2380
See related
AllianceGenome:FB:FBgn0042696
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG2380; Dmel\CG2380; NFI
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in dorsal pharyngeal muscle cell; embryonic dorsal epidermis; embryonic ventral epidermis; larval muscle system; and larval ventral nerve cord. Human ortholog(s) of this gene implicated in Marshall-Smith syndrome; NFIA-related disorder; and Sotos syndrome 2. Orthologous to several human genes including NFIC (nuclear factor I C). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See NfI in Genome Data Viewer
Location:
102B1-102B2; 4-0 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 4 NC_004353.4 (268175..276369, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 4 NC_004353.3 (288801..296995, complement)

Chromosome 4 - NC_004353.4Genomic Context describing neighboring genes Neighboring gene defective proboscis extension response 7 Neighboring gene Rho GTPase activating protein at 102A Neighboring gene long non-coding RNA:CR44023 Neighboring gene Synaptotagmin 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Single-nuclei transcriptome analysis of Huntington disease iPSC and mouse astrocytes implicates maturation and functional deficits. Reyes-Ortiz AM, et al. iScience, 2023 Jan 20. PMID 36590162, Free PMC Article
  2. Roles of the NFI/CTF gene family in transcription and development. Gronostajski RM. Gene, 2000 May 16. PMID 10831836
  3. The Nuclear Factor I (NFI) gene family in mammary gland development and function. Murtagh J, et al. J Mammary Gland Biol Neoplasia, 2003 Apr. PMID 14635798
  4. Recurrent NFIA K125E substitution represents a loss-of-function allele: Sensitive in vitro and in vivo assays for nontruncating alleles. Uehara T, et al. Am J Med Genet A, 2021 Jul. PMID 33973697, Free PMC Article
  5. The KRÜPPEL-like transcription factor DATILÓGRAFO is required in specific cholinergic neurons for sexual receptivity in Drosophila females. Schinaman JM, et al. PLoS Biol, 2014 Oct. PMID 25291190, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Recurrent NFIA K125E substitution represents a loss-of-function allele: Sensitive in vitro and in vivo assays for nontruncating alleles.
    Title: Recurrent NFIA K125E substitution represents a loss-of-function allele: Sensitive in vitro and in vivo assays for nontruncating alleles.
  2. The drosophila NfI gene structure is discussed in this paper in relation to the structures of other metazoan NFI genes.
    Title: The Nuclear Factor I (NFI) gene family in mammary gland development and function.
  3. The initial description of the Drosophila NfI gene and conserved intron positions relative to the C. elegans nfi-1 gene and vertebrate NFI genes are discussed in this paper.
    Title: Roles of the NFI/CTF gene family in transcription and development.
  4. Evidence of conserved intron locations within DNA-binding domain of Drosophila, C. elegans and Ciona NFI genes
    Title: The Nuclear Factor I (NFI) gene family in mammary gland development and function.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

mobile_element

  • Loc: c270135-269973 mobile_element_type = transposon:INE-1{}5322
  • Loc: c272913-272866 mobile_element_type = transposon:INE-1{}5323

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
nuclear factor I
Names
CG2380-PB
CG2380-PC
NfI-PB
NfI-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004353.4 Reference assembly

    Range
    268175..276369 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001272122.2 → NP_001259051.1  nuclear factor I, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259051.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    L0MPW8
    Conserved Domains (2) summary
    cl00055
    Location:85 → 193
    MH1; N-terminal Mad Homology 1 (MH1) domain
    pfam10524
    Location:25 → 64
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus

  2. NM_205870.3 → NP_995592.2  nuclear factor I, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995592.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KQN8, Q86P06
    Conserved Domains (2) summary
    cl00055
    Location:85 → 193
    MH1; N-terminal Mad Homology 1 (MH1) domain
    pfam10524
    Location:25 → 64
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
L0MPW8 L0MPW8
Q86P06 Q86P06

Gene LinkOut

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