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rbpms2a RNA binding protein, mRNA processing factor 2a [ Danio rerio (zebrafish) ]

Gene ID: 436682, updated on 2-Nov-2024

Summary

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Official Symbol
rbpms2aprovided by ZNC
Official Full Name
RNA binding protein, mRNA processing factor 2aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040718-106
See related
Ensembl:ENSDARG00000045930 AllianceGenome:ZFIN:ZDB-GENE-040718-106
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:92689
Summary
Predicted to enable mRNA binding activity. Acts upstream of or within several processes, including heart contraction; neuron projection morphogenesis; and regulation of retinal ganglion cell axon guidance. Predicted to be located in cytoplasmic stress granule; cytosol; and nucleus. Is expressed in cardiovascular system; gut; mesoderm; pleuroperitoneal region; and retina. Orthologous to human RBPMS2 (RNA binding protein, mRNA processing factor 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See rbpms2a in Genome Data Viewer
Location:
chromosome: 25
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 25 NC_007136.7 (6122942..6149982)
105 previous assembly GRCz10 (GCF_000002035.5) 25 NC_007136.6 (5995527..6022580)

Chromosome 25 - NC_007136.7Genomic Context describing neighboring genes Neighboring gene synaptic vesicle glycoprotein 2 Neighboring gene cytoplasmic polyadenylation element binding protein 1a Neighboring gene ornithine decarboxylase antizyme 2a Neighboring gene proteasome 20S subunit alpha 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Exploring the Activities of RBPMS Proteins in Myocardial Biology. Akerberg AA, et al. Pediatr Cardiol, 2019 Oct. PMID 31399780, Free PMC Article
  2. RNA-binding protein Hermes/RBPMS inversely affects synapse density and axon arbor formation in retinal ganglion cells in vivo. Hörnberg H, et al. J Neurosci, 2013 Jun 19. PMID 23785151, Free PMC Article
  3. rbpms2 functions in Balbiani body architecture and ovary fate. Kaufman OH, et al. PLoS Genet, 2018 Jul. PMID 29975683, Free PMC Article
  4. Genome-wide Trans-ethnic Meta-analysis Identifies Seven Genetic Loci Influencing Erythrocyte Traits and a Role for RBPMS in Erythropoiesis. van Rooij FJA, et al. Am J Hum Genet, 2017 Jan 5. PMID 28017375, Free PMC Article
  5. RBPMS2 Is a Myocardial-Enriched Splicing Regulator Required for Cardiac Function. Akerberg AA, et al. Circ Res, 2022 Dec 2. PMID 36367103, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RBPMS2 Is a Myocardial-Enriched Splicing Regulator Required for Cardiac Function.
    Title: RBPMS2 Is a Myocardial-Enriched Splicing Regulator Required for Cardiac Function.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within dendrite morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within female sex differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within female sex differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heart contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heart morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of smooth muscle cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within regulation of retinal ganglion cell axon guidance IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within retinal ganglion cell axon guidance IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic stress granule ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
RNA-binding protein, mRNA-processing factor 2a
Names
RNA binding protein with multiple splicing 2a
heart and RRM expressed sequence
hermes
protein hermes A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002409.1 → NP_001002409.1  RNA-binding protein, mRNA-processing factor 2a

    See identical proteins and their annotated locations for NP_001002409.1

    Status: PROVISIONAL

    Source sequence(s)
    BC076171
    UniProtKB/Swiss-Prot
    Q6DH13
    Related
    ENSDARP00000067513.4, ENSDART00000067514.6
    Conserved Domains (1) summary
    cd12683
    Location:19 → 94
    RRM_RBPMS2; RNA recognition motif (RRM) found in vertebrate RNA-binding protein with multiple splicing 2 (RBP-MS2)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007136.7 Reference GRCz11 Primary Assembly

    Range
    6122942..6149982
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021470475.2 → XP_021326150.1  RNA-binding protein, mRNA-processing factor 2a isoform X3

    UniProtKB/TrEMBL
    A0A8M9PYB9
    Conserved Domains (1) summary
    cd12683
    Location:70 → 145
    RRM_RBPMS2; RNA recognition motif in vertebrate RNA-binding protein with multiple splicing 2 (RBP-MS2)

  2. XM_021470473.2 → XP_021326148.1  RNA-binding protein, mRNA-processing factor 2a isoform X1

    UniProtKB/TrEMBL
    A0A8M9PGS4
    Conserved Domains (1) summary
    cd12683
    Location:70 → 145
    RRM_RBPMS2; RNA recognition motif in vertebrate RNA-binding protein with multiple splicing 2 (RBP-MS2)

  3. XM_021470476.2 → XP_021326151.1  RNA-binding protein, mRNA-processing factor 2a isoform X4

    UniProtKB/TrEMBL
    A0A8M9PUW5
    Conserved Domains (1) summary
    cd12683
    Location:70 → 145
    RRM_RBPMS2; RNA recognition motif in vertebrate RNA-binding protein with multiple splicing 2 (RBP-MS2)

  4. XM_021470474.2 → XP_021326149.1  RNA-binding protein, mRNA-processing factor 2a isoform X2

    UniProtKB/TrEMBL
    A0A8M9PMP2
    Conserved Domains (1) summary
    cd12683
    Location:70 → 145
    RRM_RBPMS2; RNA recognition motif in vertebrate RNA-binding protein with multiple splicing 2 (RBP-MS2)

  5. XM_005162967.5 → XP_005163024.1  RNA-binding protein, mRNA-processing factor 2a isoform X7

    UniProtKB/TrEMBL
    A0A8M2B9Y7
    Conserved Domains (1) summary
    cl17169
    Location:19 → 94
    RRM_SF; RNA recognition motif (RRM) superfamily

  6. XM_009297758.4 → XP_009296033.1  RNA-binding protein, mRNA-processing factor 2a isoform X5

    UniProtKB/TrEMBL
    A0A8M3AWB5
    Conserved Domains (1) summary
    cl17169
    Location:19 → 94
    RRM_SF; RNA recognition motif (RRM) superfamily

  7. XM_068217360.1 → XP_068073461.1  RNA-binding protein, mRNA-processing factor 2a isoform X6

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6DH13.1 GenPept UniProtKB/Swiss-Prot:Q6DH13

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