eef1a2 eukaryotic translation elongation factor 1 alpha 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: eef1a2provided by ZNC
Official Full Name: eukaryotic translation elongation factor 1 alpha 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-040718-64
See related: Ensembl:ENSDARG00000006838 AllianceGenome:ZFIN:ZDB-GENE-040718-64
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:92085
Summary: Predicted to enable GTPase activity and translation elongation factor activity. Predicted to be involved in translational elongation. Is expressed in central nervous system; muscle; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability 38; developmental and epileptic encephalopathy 33; and ovarian cancer. Orthologous to human EEF1A2 (eukaryotic translation elongation factor 1 alpha 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 23

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	23	NC_007134.7 (15850938..15878879, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	23	NC_007134.6 (16094861..16122802, complement)

Chromosome 23 - NC_007134.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables translation elongation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation elongation factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in translation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within translation	IEA Inferred from Electronic Annotation more info
involved_in translational elongation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within translational elongation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: elongation factor 1-alpha 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002371.1 → NP_001002371.1 elongation factor 1-alpha 2

See identical proteins and their annotated locations for NP_001002371.1

Status: PROVISIONAL

Source sequence(s)

BC075885

UniProtKB/TrEMBL

A0A8M1N084, Q6DHT2

Related

ENSDARP00000010921.6, ENSDART00000010119.7

Conserved Domains (4) summary

PTZ00141
Location:1 → 460

PTZ00141; elongation factor 1- alpha; Provisional

cd01883
Location:9 → 238

EF1_alpha; Elongation Factor 1-alpha (EF1-alpha) protein family

cd03693
Location:242 → 332

EF1_alpha_II; Domain II of elongation factor 1-alpha

cd03705
Location:336 → 438

EF1_alpha_III; Domain III of Elongation Factor 1