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CG2246 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43637, updated on 2-Nov-2024

Summary

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Official Symbol
CG2246provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0039790
Locus tag
Dmel_CG2246
See related
AllianceGenome:FB:FBgn0039790
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG2246
Summary
Predicted to enable enzyme regulator activity. Predicted to be involved in 5-phosphoribose 1-diphosphate biosynthetic process and purine nucleotide biosynthetic process. Predicted to be active in cytoplasm. Is expressed in several structures, including adult head; embryonic/larval midgut primordium; gut section; mesoderm; and visceral mesoderm derivative. Orthologous to several human genes including PRPSAP2 (phosphoribosyl pyrophosphate synthetase associated protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See CG2246 in Genome Data Viewer
Location:
99F10-100A1; 3-100 cM
Exon count:
11
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (30592971..30601489, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (26418693..26427211, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Regulatory particle triple-A ATPase 6-related Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene prolyl-4-hydroxylase-alpha NE3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. PRPS-Associated Disorders and the Drosophila Model of Arts Syndrome. Delos Santos K, et al. Int J Mol Sci, 2020 Jul 8. PMID 32650483, Free PMC Article
  2. A computational and experimental approach toward a priori identification of alternatively spliced exons. Philipps DL, et al. RNA, 2004 Dec. PMID 15525709, Free PMC Article
  3. Proteins rather than mRNAs regulate nucleation and persistence of Oskar germ granules in Drosophila. Curnutte HA, et al. Cell Rep, 2023 Jul 25. PMID 37384531, Free PMC Article
  4. Genome-wide phenotypic RNAi screen in the Drosophila wing: global parameters. López-Varea A, et al. G3 (Bethesda), 2021 Dec 8. PMID 34599819, Free PMC Article
  5. Sex-Specific Transcript Diversity in the Fly Head Is Established during Pupal Stages and Adulthood and Is Largely Independent of the Mating Process and the Germline. Mohr C, et al. Sex Dev, 2017. PMID 28273663

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables enzyme regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 5-phosphoribose 1-diphosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in purine nucleotide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG2246-PA
CG2246-PB
CG2246-PC
CG2246-PD
CG2246-PE
CG2246-PF
CG2246-PG
CG2246-PH
CG2246-PI
CG2246-PJ
CG2246-PK
CG2246-PL
CG2246-PM
CG2246-PN
CG2246-PO
CG2246-PP
NP_001163778.1
NP_001189321.1
NP_001189322.1
NP_001189323.1
NP_001189324.1
NP_001189325.1
NP_001189326.1
NP_001263115.1
NP_001263116.1
NP_001263117.1
NP_651813.2
NP_733386.1
NP_733387.1
NP_733388.1
NP_733389.2
NP_733390.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    30592971..30601489 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001202395.2 → NP_001189324.1  uncharacterized protein Dmel_CG2246, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189324.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q961V3
    Conserved Domains (2) summary
    pfam13793
    Location:9 → 124
    Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
    pfam14572
    Location:165 → 361
    Pribosyl_synth; Phosphoribosyl synthetase-associated domain

  2. NM_170511.2 → NP_733390.1  uncharacterized protein Dmel_CG2246, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733390.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KRU0
    Related
    FBpp0085036
    Conserved Domains (2) summary
    pfam13793
    Location:9 → 124
    Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
    pfam14572
    Location:165 → 380
    Pribosyl_synth; Phosphoribosyl synthetase-associated domain

  3. NM_170507.2 → NP_733386.1  uncharacterized protein Dmel_CG2246, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733386.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IMI0
    Related
    FBpp0085037
    Conserved Domains (2) summary
    pfam13793
    Location:29 → 144
    Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
    pfam14572
    Location:185 → 381
    Pribosyl_synth; Phosphoribosyl synthetase-associated domain

  4. NM_001202392.2 → NP_001189321.1  uncharacterized protein Dmel_CG2246, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189321.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VA53
    Conserved Domains (2) summary
    pfam13793
    Location:29 → 144
    Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
    pfam14572
    Location:185 → 400
    Pribosyl_synth; Phosphoribosyl synthetase-associated domain

  5. NM_170510.2 → NP_733389.2  uncharacterized protein Dmel_CG2246, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733389.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VA53
    Related
    FBpp0085035
    Conserved Domains (2) summary
    pfam13793
    Location:29 → 144
    Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
    pfam14572
    Location:185 → 400
    Pribosyl_synth; Phosphoribosyl synthetase-associated domain

  6. NM_001202396.2 → NP_001189325.1  uncharacterized protein Dmel_CG2246, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189325.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q961V3
    Conserved Domains (2) summary
    pfam13793
    Location:9 → 124
    Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
    pfam14572
    Location:165 → 361
    Pribosyl_synth; Phosphoribosyl synthetase-associated domain

  7. NM_001202397.2 → NP_001189326.1  uncharacterized protein Dmel_CG2246, isoform M [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189326.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q961V3
    Conserved Domains (2) summary
    pfam13793
    Location:9 → 124
    Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
    pfam14572
    Location:165 → 361
    Pribosyl_synth; Phosphoribosyl synthetase-associated domain

  8. NM_001276188.1 → NP_001263117.1  uncharacterized protein Dmel_CG2246, isoform P [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001263117.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KHW7
    Conserved Domains (3) summary
    COG0462
    Location:5 → 350
    PrsA; Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism, Amino acid transport and metabolism]
    pfam13793
    Location:9 → 124
    Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
    pfam14572
    Location:165 → 350
    Pribosyl_synth; Phosphoribosyl synthetase-associated domain

  9. NM_170508.2 → NP_733387.1  uncharacterized protein Dmel_CG2246, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733387.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q961V3
    Related
    FBpp0085038
    Conserved Domains (2) summary
    pfam13793
    Location:9 → 124
    Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
    pfam14572
    Location:165 → 361
    Pribosyl_synth; Phosphoribosyl synthetase-associated domain

  10. NM_143556.4 → NP_651813.2  uncharacterized protein Dmel_CG2246, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651813.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KRU0
    Related
    FBpp0085040
    Conserved Domains (2) summary
    pfam13793
    Location:9 → 124
    Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
    pfam14572
    Location:165 → 380
    Pribosyl_synth; Phosphoribosyl synthetase-associated domain

  11. NM_170509.2 → NP_733388.1  uncharacterized protein Dmel_CG2246, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733388.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q961V3
    Related
    FBpp0085039
    Conserved Domains (2) summary
    pfam13793
    Location:9 → 124
    Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
    pfam14572
    Location:165 → 361
    Pribosyl_synth; Phosphoribosyl synthetase-associated domain

  12. NM_001202394.2 → NP_001189323.1  uncharacterized protein Dmel_CG2246, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189323.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4JD23
    Conserved Domains (2) summary
    pfam13793
    Location:27 → 142
    Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
    pfam14572
    Location:183 → 379
    Pribosyl_synth; Phosphoribosyl synthetase-associated domain

  13. NM_001202393.2 → NP_001189322.1  uncharacterized protein Dmel_CG2246, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189322.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4JDE3
    Conserved Domains (2) summary
    pfam13793
    Location:27 → 142
    Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
    pfam14572
    Location:183 → 398
    Pribosyl_synth; Phosphoribosyl synthetase-associated domain

  14. NM_001276186.1 → NP_001263115.1  uncharacterized protein Dmel_CG2246, isoform N [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001263115.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KHJ3
    Conserved Domains (2) summary
    pfam13793
    Location:29 → 144
    Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
    pfam14572
    Location:185 → 370
    Pribosyl_synth; Phosphoribosyl synthetase-associated domain

  15. NM_001276187.1 → NP_001263116.1  uncharacterized protein Dmel_CG2246, isoform O [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001263116.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KHF5
    Conserved Domains (2) summary
    pfam13793
    Location:29 → 144
    Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
    pfam14572
    Location:185 → 371
    Pribosyl_synth; Phosphoribosyl synthetase-associated domain

  16. NM_001170307.1 → NP_001163778.1  uncharacterized protein Dmel_CG2246, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163778.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8IMI0
    Conserved Domains (2) summary
    pfam13793
    Location:29 → 144
    Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase
    pfam14572
    Location:185 → 381
    Pribosyl_synth; Phosphoribosyl synthetase-associated domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4JD23 A0A0B4JD23
A0A0B4JDE3 A0A0B4JDE3
A0A0B4KHF5 A0A0B4KHF5
A0A0B4KHJ3 A0A0B4KHJ3
A0A0B4KHW7 A0A0B4KHW7
Q7KRU0 Q7KRU0
Q8IMI0 Q8IMI0
Q961V3 Q961V3
Q9VA53 Q9VA53

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