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Nf1 Neurofibromin 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43149, updated on 2-Nov-2024

Summary

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Official Symbol
Nf1provided by FlyBase
Official Full Name
Neurofibromin 1provided by FlyBase
Primary source
FLYBASE:FBgn0015269
Locus tag
Dmel_CG8318
See related
AllianceGenome:FB:FBgn0015269
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8318; Dmel\CG8318; dNf1; dNF1; FBpp0084326; Nf-1; NF-1; nf1; NF1
Summary
Enables GTPase activator activity. Involved in several processes, including Ras protein signal transduction; determination of adult lifespan; and learning or memory. Is expressed in several structures, including adult brain; adult brain cell body rind; adult head; ganglia; and synaptic neuropil domain. Used to study attention deficit hyperactivity disorder; neurofibromatosis; neurofibromatosis 1; and sleep disorder. Human ortholog(s) of this gene implicated in several diseases, including Watson syndrome; autistic disorder; hematologic cancer (multiple); neurofibromatosis 1 (multiple); and peripheral nervous system neoplasm (multiple). Orthologous to human NF1 (neurofibromin 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Nf1 in Genome Data Viewer
Location:
96F9-96F9; 3-89 cM
Exon count:
19
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25983013..25995737)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21808735..21821459)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene bride of sevenless Neighboring gene fire dancer Neighboring gene Enhancer of split mdelta, helix-loop-helix Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Developmental loss of neurofibromin across distributed neuronal circuits drives excessive grooming in Drosophila. King LB, et al. PLoS Genet, 2020 Jul. PMID 32697780, Free PMC Article
  2. Polymorphism in the neurofibromin gene, Nf1, is associated with antagonistic selection on wing size and development time in Drosophila melanogaster. Lee SF, et al. Mol Ecol, 2013 May. PMID 23506114, Free PMC Article
  3. Drosophila Contributions towards Understanding Neurofibromatosis 1. Atsoniou K, et al. Cells, 2024 Apr 21. PMID 38667335, Free PMC Article
  4. Neurofibromin 1 mediates sleep depth in Drosophila. Brown EB, et al. PLoS Genet, 2023 Dec. PMID 38091360, Free PMC Article
  5. A particular GAP in mind. Zhu Y, et al. Nat Genet, 2001 Apr. PMID 11279509

See all (138) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Neurofibromin 1 mediates sleep depth in Drosophila.
    Title: Neurofibromin 1 mediates sleep depth in Drosophila.
  2. Neurofibromin 1 in mushroom body neurons mediates circadian wake drive through activating cAMP-PKA signaling.
    Title: Neurofibromin 1 in mushroom body neurons mediates circadian wake drive through activating cAMP-PKA signaling.
  3. Social Behavioral Deficits with Loss of Neurofibromin Emerge from Peripheral Chemosensory Neuron Dysfunction.
    Title: Social Behavioral Deficits with Loss of Neurofibromin Emerge from Peripheral Chemosensory Neuron Dysfunction.
  4. Developmental loss of neurofibromin across distributed neuronal circuits drives excessive grooming in Drosophila.
    Title: Developmental loss of neurofibromin across distributed neuronal circuits drives excessive grooming in Drosophila.
  5. Polymorphism in the neurofibromin gene, Nf1, is associated with antagonistic selection on wing size and development time in Drosophila melanogaster.
    Title: Polymorphism in the neurofibromin gene, Nf1, is associated with antagonistic selection on wing size and development time in Drosophila melanogaster.
  6. The N-terminal region of NF1 mediates the interaction with Fak56 and is required for the signaling activity and presynaptic localization of NF1
    Title: Neurofibromin mediates FAK signaling in confining synapse growth at Drosophila neuromuscular junctions.
  7. These results identify dAlk as an upstream activator of dNf1-regulated Ras signaling responsible for several dNf1 defects, and they implicate human Alk as a potential therapeutic target in NF1
    Title: The receptor tyrosine kinase Alk controls neurofibromin functions in Drosophila growth and learning.
  8. memory-related functions of Rut-AC are both Nf1-dependent and -independent, that Nf1 mediates the formation of two distinct memory components within a single neuron population.
    Title: A distinct set of Drosophila brain neurons required for neurofibromatosis type 1-dependent learning and memory.
  9. survival of a subset of midline glia cells depends upon direct suppression of the proapoptotic protein HID via the EGF receptor/RAS/MAPK pathway
    Title: Regulation of cell number by MAPK-dependent control of apoptosis: a mechanism for trophic survival signaling.
  10. Data show that rolled nuclear translocation is regulated by a second mechanism in addition to phosphorylation, and may be held in the cytoplasm for hours.
    Title: Nuclear translocation of activated MAP kinase is developmentally regulated in the developing Drosophila eye.
Submit: New GeneRIF Correction See all GeneRIFs (17)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA surveillance IEA
Inferred from Electronic Annotation
more info
  
involved_in Ras protein signal transduction IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in adult locomotory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in locomotor rhythm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in long-term memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of synaptic assembly at neuromuscular junction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear-transcribed mRNA catabolic process, no-go decay IEA
Inferred from Electronic Annotation
more info
  
involved_in nuclear-transcribed mRNA catabolic process, non-stop decay IEA
Inferred from Electronic Annotation
more info
  
involved_in olfactory learning IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in perineurial glial growth IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of Ras protein signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of circadian rhythm IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to heat IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in short-term memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sleep IGI
Inferred from Genetic Interaction
more info
 PubMed 

General protein information

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Preferred Names
neurofibromin 1
Names
CG8318-PB
CG8318-PC
CG8318-PD
CG8318-PE
CG8318-PF
Neurofibromatosis-1
Nf1-PB
Nf1-PC
Nf1-PD
Nf1-PE
Nf1-PF
neurofibramatosis-1
neurofibromatosis 1
neurofibromatosis factor 1
neurofibromatosis type 1
neurofibromin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    25983013..25995737
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001014668.2 → NP_001014668.1  neurofibromin 1, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014668.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O01399, Q59DT9
    Conserved Domains (4) summary
    cd05130
    Location:1242 → 1575
    RasGAP_Neurofibromin; Ras-GTPase Activating Domain of neurofibromin
    cd13313
    Location:1759 → 1868
    PH_NF1; Neurofibromin-1 Pleckstrin homology-like domain
    pfam14228
    Location:1931 → 2109
    MOR2-PAG1_mid; Cell morphogenesis central region
    pfam13716
    Location:1633 → 1767
    CRAL_TRIO_2; Divergent CRAL/TRIO domain

  2. NM_001276049.1 → NP_001262978.1  neurofibromin 1, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262978.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KI28, O01399
    Conserved Domains (5) summary
    cd05130
    Location:1242 → 1575
    RasGAP_Neurofibromin; Ras-GTPase Activating Domain of neurofibromin
    smart00323
    Location:1227 → 1581
    RasGAP; GTPase-activator protein for Ras-like GTPases
    cd13313
    Location:1759 → 1868
    PH_NF1; Neurofibromin-1 Pleckstrin homology-like domain
    pfam13716
    Location:1633 → 1759
    CRAL_TRIO_2; Divergent CRAL/TRIO domain
    pfam14228
    Location:1931 → 2086
    MOR2-PAG1_mid; Cell morphogenesis central region

  3. NM_001276050.1 → NP_001262979.1  neurofibromin 1, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262979.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KHX4, O01399
    Conserved Domains (5) summary
    cd05130
    Location:1242 → 1575
    RasGAP_Neurofibromin; Ras-GTPase Activating Domain of neurofibromin
    smart00323
    Location:1227 → 1581
    RasGAP; GTPase-activator protein for Ras-like GTPases
    cd13313
    Location:1759 → 1868
    PH_NF1; Neurofibromin-1 Pleckstrin homology-like domain
    pfam13716
    Location:1633 → 1759
    CRAL_TRIO_2; Divergent CRAL/TRIO domain
    pfam14228
    Location:1931 → 2086
    MOR2-PAG1_mid; Cell morphogenesis central region

  4. NM_170252.3 → NP_733131.2  neurofibromin 1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733131.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    O01399, Q8IMS2
    Related
    FBpp0084327
    Conserved Domains (4) summary
    cd05130
    Location:1242 → 1575
    RasGAP_Neurofibromin; Ras-GTPase Activating Domain of neurofibromin
    cd13313
    Location:1759 → 1868
    PH_NF1; Neurofibromin-1 Pleckstrin homology-like domain
    pfam14228
    Location:1931 → 2109
    MOR2-PAG1_mid; Cell morphogenesis central region
    pfam13716
    Location:1633 → 1767
    CRAL_TRIO_2; Divergent CRAL/TRIO domain

  5. NM_170253.2 → NP_733132.2  neurofibromin 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_733132.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    O01397, O01398, Q9VBJ2
    Related
    FBpp0084326, FBtr0084952
    Conserved Domains (4) summary
    cd05130
    Location:1242 → 1575
    RasGAP_Neurofibromin; Ras-GTPase Activating Domain of neurofibromin
    cd13313
    Location:1759 → 1868
    PH_NF1; Neurofibromin-1 Pleckstrin homology-like domain
    pfam14228
    Location:1931 → 2109
    MOR2-PAG1_mid; Cell morphogenesis central region
    pfam13716
    Location:1633 → 1767
    CRAL_TRIO_2; Divergent CRAL/TRIO domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KHX4 A0A0B4KHX4
A0A0B4KI28 A0A0B4KI28
O01397 O01397
O01398 O01398
O01399 O01399
Q59DT9 Q59DT9
Q8IMS2 Q8IMS2
Q95U43 Q95U43
Q9VBJ2 Q9VBJ2

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