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MMP2 matrix metallopeptidase 2 [ Homo sapiens (human) ]

Gene ID: 4313, updated on 6-Oct-2024

Summary

Official Symbol
MMP2provided by HGNC
Official Full Name
matrix metallopeptidase 2provided by HGNC
Primary source
HGNC:HGNC:7166
See related
Ensembl:ENSG00000087245 MIM:120360; AllianceGenome:HGNC:7166
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CLG4; MONA; CLG4A; MMP-2; TBE-1; MMP-II
Summary
This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
Expression
Broad expression in gall bladder (RPKM 482.6), urinary bladder (RPKM 341.0) and 15 other tissues See more
Orthologs
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Try the new Transcript table

Genomic context

See MMP2 in Genome Data Viewer
Location:
16q12.2
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (55478830..55506691)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (61276956..61304813)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (55512742..55540603)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371279 Neighboring gene VISTA enhancer hs23 Neighboring gene MMP2 antisense RNA 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:55503673-55504564 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:55504565-55505455 Neighboring gene NANOG hESC enhancer GRCh37_chr16:55508340-55508859 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:55536405-55536906 Neighboring gene lysophosphatidylcholine acyltransferase 2 Neighboring gene calpain small subunit 2 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:55633008-55633567 Neighboring gene Sharpr-MPRA regulatory region 3138 Neighboring gene uncharacterized LOC124903693 Neighboring gene solute carrier family 6 member 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 JRFL Env (gp120) upregulates MMP2 in ARPE-19 and primary human RPE cells and is dependent upon DC-SIGN PubMed
env HIV-1 gp120 interaction with human mannose receptor (hMR) results in increased production of matrix metalloproteinase-2 (MMP-2) in astrocytes PubMed
env Matrix metalloproteinases MMP2 and MMP9 participate in the maturation process of cleavage and activation of IL-1beta based on the intracerebroventricular injection of the HIV-1 envelope glycoprotein gp120 PubMed
Envelope transmembrane glycoprotein gp41 env Treatment of human glial and neuronal cells with an HIV-1 gp41 peptide (amino acids 583-599) markedly increases the activity of matrix metalloproteinase 2 (MMP-2) PubMed
Nef nef Overexpression of HIV-1 Nef and ALK effect gelatinase activation in astrocytic glioma cells PubMed
Tat tat HIV-1 Tat from AIDS patients with HIV-associated dementia upregulates MMP-2 and MMP-7 release and activation, leading to neurotoxicity PubMed
tat HIV-1 Tat and methamphetamine enhance the release of MMP-1, MMP-2, and uPA from human brain cells PubMed
tat HIV-1 Tat and bFGF synergize to upregulate MMP-2 (type-IV collagenase) secretion and activation in endothelial cells and also synergize in inducing angiogenic Kaposi's sarcoma-like lesions in mice as a result of enhanced MMP-2 expression PubMed
Vpu vpu HIV-1 Vpu-expressing U937 monocytes coculture with LX2 stellate cells to upregulate expression of profibrogenic markers COL-1, PCT, SMA-1, VEGF, and MMP2, which is inhibited by MIF treatment PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables fibronectin binding IEA
Inferred from Electronic Annotation
more info
 
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metalloendopeptidase activity TAS
Traceable Author Statement
more info
 
enables metallopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables serine-type endopeptidase activity EXP
Inferred from Experiment
more info
PubMed 
enables serine-type endopeptidase activity TAS
Traceable Author Statement
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in blood vessel maturation IEA
Inferred from Electronic Annotation
more info
 
involved_in bone trabecula formation IEA
Inferred from Electronic Annotation
more info
 
involved_in cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to UV-A IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to amino acid stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to estradiol stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to fluid shear stress IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to interleukin-1 IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to reactive oxygen species IEA
Inferred from Electronic Annotation
more info
 
involved_in collagen catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in collagen catabolic process TAS
Traceable Author Statement
more info
 
involved_in embryo implantation IEA
Inferred from Electronic Annotation
more info
 
involved_in endodermal cell differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in ephrin receptor signaling pathway TAS
Traceable Author Statement
more info
 
involved_in extracellular matrix disassembly TAS
Traceable Author Statement
more info
PubMed 
involved_in extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in face morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in heart development IEA
Inferred from Electronic Annotation
more info
 
involved_in intramembranous ossification IEA
Inferred from Electronic Annotation
more info
 
involved_in luteinization IEA
Inferred from Electronic Annotation
more info
 
involved_in macrophage chemotaxis IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of vasoconstriction IEA
Inferred from Electronic Annotation
more info
 
involved_in ovarian follicle development IEA
Inferred from Electronic Annotation
more info
 
involved_in ovulation from ovarian follicle IEA
Inferred from Electronic Annotation
more info
 
involved_in parturition IEA
Inferred from Electronic Annotation
more info
 
involved_in peripheral nervous system axon regeneration IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of vascular associated smooth muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in prostate gland epithelium morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to activity IEA
Inferred from Electronic Annotation
more info
 
involved_in response to amyloid-beta ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to electrical stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in response to estrogen IEA
Inferred from Electronic Annotation
more info
 
involved_in response to hydrogen peroxide IEA
Inferred from Electronic Annotation
more info
 
involved_in response to hyperoxia IEA
Inferred from Electronic Annotation
more info
 
involved_in response to hypoxia IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to mechanical stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in response to nicotine IEA
Inferred from Electronic Annotation
more info
 
involved_in response to retinoic acid IEA
Inferred from Electronic Annotation
more info
 
involved_in response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in tissue remodeling IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
72 kDa type IV collagenase
Names
collagenase type IV-A
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
matrix metalloproteinase-2
matrix metalloproteinase-II
neutrophil gelatinase
NP_001121363.1
NP_001289437.1
NP_001289438.1
NP_001289439.1
NP_004521.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008989.1 RefSeqGene

    Range
    5030..32523
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001127891.3NP_001121363.1  72 kDa type IV collagenase isoform 2

    See identical proteins and their annotated locations for NP_001121363.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AC007336, AK310314, BQ004983, BX357054
    Consensus CDS
    CCDS45487.1
    UniProtKB/Swiss-Prot
    P08253
    Related
    ENSP00000394237.2, ENST00000437642.6
    Conserved Domains (5) summary
    smart00059
    Location:292340
    FN2; Fibronectin type 2 domain
    cd00094
    Location:416610
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:68396
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    pfam00413
    Location:68396
    Peptidase_M10; Matrixin
    pfam01471
    Location:2047
    PG_binding_1; Putative peptidoglycan binding domain
  2. NM_001302508.1NP_001289437.1  72 kDa type IV collagenase isoform 3

    See identical proteins and their annotated locations for NP_001289437.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' terminal exon, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1. Variants 3, 4, and 5 all encode the same isoform (3).
    Source sequence(s)
    AC007336, AK301536, BQ004983, BX357054, DA579926
    Consensus CDS
    CCDS76869.1
    UniProtKB/Swiss-Prot
    P08253
    Conserved Domains (4) summary
    smart00059
    Location:266314
    FN2; Fibronectin type 2 domain
    cd00094
    Location:390584
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:42370
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    pfam00413
    Location:42370
    Peptidase_M10; Matrixin
  3. NM_001302509.2NP_001289438.1  72 kDa type IV collagenase isoform 3

    See identical proteins and their annotated locations for NP_001289438.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an alternate 5' terminal exon, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1. Variants 3, 4, and 5 all encode the same isoform (3).
    Source sequence(s)
    AK301536, BQ004983, BX357054
    Consensus CDS
    CCDS76869.1
    UniProtKB/Swiss-Prot
    P08253
    Related
    ENSP00000444143.1, ENST00000543485.5
    Conserved Domains (4) summary
    smart00059
    Location:266314
    FN2; Fibronectin type 2 domain
    cd00094
    Location:390584
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:42370
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    pfam00413
    Location:42370
    Peptidase_M10; Matrixin
  4. NM_001302510.2NP_001289439.1  72 kDa type IV collagenase isoform 3

    See identical proteins and their annotated locations for NP_001289439.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains an alternate 5' terminal exon, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus than isoform 1. Variants 3, 4, and 5 all encode the same isoform (3).
    Source sequence(s)
    AK301536, AU133104, BQ004983, BX357054
    Consensus CDS
    CCDS76869.1
    UniProtKB/Swiss-Prot
    P08253
    Related
    ENSP00000461421.1, ENST00000570308.5
    Conserved Domains (4) summary
    smart00059
    Location:266314
    FN2; Fibronectin type 2 domain
    cd00094
    Location:390584
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:42370
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    pfam00413
    Location:42370
    Peptidase_M10; Matrixin
  5. NM_004530.6NP_004521.1  72 kDa type IV collagenase isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_004521.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC007336, AK312711, BP341649, BQ004983, BX357054
    Consensus CDS
    CCDS10752.1
    UniProtKB/Swiss-Prot
    B2R6U1, B4DWH3, E9PE45, P08253, Q9UCJ8
    Related
    ENSP00000219070.4, ENST00000219070.9
    Conserved Domains (4) summary
    smart00059
    Location:342390
    FN2; Fibronectin type 2 domain
    cd00094
    Location:466660
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam00413
    Location:118446
    Peptidase_M10; Matrixin
    pfam01471
    Location:7097
    PG_binding_1; Putative peptidoglycan binding domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    55478830..55506691
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    61276956..61304813
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)