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CXCR1 C-X-C motif chemokine receptor 1 [ Gallus gallus (chicken) ]

Gene ID: 430652, updated on 17-Aug-2024

Summary

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Symbol
CXCR1provided by CGNC
Full Name
C-X-C motif chemokine receptor 1provided by CGNC
Primary source
CGNC:15413
See related
Ensembl:ENSGALG00010019250
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
CXCR2; IL8RB
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Genomic context

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See CXCR1 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
3
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 7 NC_052538.1 (22210751..22213598)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 7 NC_052579.1 (22130403..22133249)

Chromosome 7 - NC_052538.1Genomic Context describing neighboring genes Neighboring gene transmembrane BAX inhibitor motif containing 1 Neighboring gene paroxysmal nonkinesigenic dyskinesia Neighboring gene angio associated migratory cell protein Neighboring gene actin related protein 2/3 complex subunit 2 Neighboring gene RUN and FYVE domain containing 4 Neighboring gene tensin 1 Neighboring gene uncharacterized LOC101749755

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. cCXCR1 is a receptor for cIL-8 (9E3/cCAF) and its N- and C-terminal peptides and is also activated by hIL-8 (CXCL8). Li QJ, et al. J Leukoc Biol, 2005 Mar. PMID 15576419
  2. Isolation and characterization of a new chemokine receptor gene, the putative chicken CXCR1. Li QJ, et al. Gene, 2000 Oct 31. PMID 11080597
  3. Re-evaluation of chicken CXCR1 determines the true gene structure: CXCLi1 (K60) and CXCLi2 (CAF/interleukin-8) are ligands for this receptor. Poh TY, et al. J Biol Chem, 2008 Jun 13. PMID 18417470
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The chicken CXCR1 Receptor is activated by chicken IL-8 and its N- and C-terminal peptides and whether it responds to human IL-8.
    Title: cCXCR1 is a receptor for cIL-8 (9E3/cCAF) and its N- and C-terminal peptides and is also activated by hIL-8 (CXCL8).
  2. CXCLi1 (K60) and CXCLi2 (CAF/interleukin-8) look equally like orthologues of human CXCL8 and are ligands for chicken CXCR1
    Title: Re-evaluation of chicken CXCR1 determines the true gene structure: CXCLi1 (K60) and CXCLi2 (CAF/interleukin-8) are ligands for this receptor.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables C-X-C chemokine receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in neutrophil chemotaxis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
C-X-C chemokine receptor type 2
Names
G-protein coupled receptor
chemokine (C-X-C motif) receptor 1
chemokine (C-X-C motif) receptor 2
interleukin 8 receptor, beta
putative C-X-C chemokine receptor type 1, CXCR1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282432.2 → NP_001269361.1  C-X-C chemokine receptor type 2

    See identical proteins and their annotated locations for NP_001269361.1

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000236
    UniProtKB/TrEMBL
    Q334G8
    Conserved Domains (1) summary
    pfam00001
    Location:78 → 313
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052538.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    22210751..22213598
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015289858.4 → XP_015145344.1  C-X-C chemokine receptor type 2 isoform X1

    UniProtKB/TrEMBL
    Q334G8
    Related
    ENSGALP00010027706.1, ENSGALT00010046535.1
    Conserved Domains (1) summary
    pfam00001
    Location:78 → 313
    7tm_1; 7 transmembrane receptor (rhodopsin family)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052579.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    22130403..22133249
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046921667.1 → XP_046777623.1  C-X-C chemokine receptor type 2 isoform X1

    UniProtKB/TrEMBL
    Q334G8

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001031591.1: Suppressed sequence

    Description
    NM_001031591.1: This RefSeq was permanently suppressed because there were insertions and deletions compared to available sequence data. These differences resulted in frame-shifts and a protein that is not supported by available protein (homology) data.
Nucleotide Protein Strain
Heading Accession and Version

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