CYR61 cysteine rich angiogenic inducer 61 [Gallus gallus (chicken)] - Gene

Summary

Symbol: CYR61provided by CGNC
Full Name: cysteine rich angiogenic inducer 61provided by CGNC
Primary source: CGNC:53551
See related: Ensembl:ENSGALG00010020677
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: CCN1
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	8	NC_052539.1 (15923041..15925475, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	8	NC_052580.1 (15931668..15934101, complement)

Chromosome 8 - NC_052539.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Upregulation of Cyr61 significantly decreased IM-induced cellular apoptosis of K562 cells through nuclear factor kappa B/B-cell lymphoma 2 pathways.
Title: Cysteine-rich protein 61 regulates the chemosensitivity of chronic myeloid leukemia to imatinib mesylate through the nuclear factor kappa B/Bcl-2 pathway.
Overexpression of Btg1 induced intense upregulation of Ccn1. In complementary knockdown experiments, this marker was regulated in an opposite fashion.
Title: The tumor suppressor BTG1 is expressed in the developing digits and regulates skeletogenic differentiation of limb mesodermal progenitors in high density cultures.
Ccn1 appeared as a precocious marker of the digit blastemas. As development progressed, transcripts accumulated in the developing joints and in the tendon blastemas, whereas expression in the digit rays was restricted to the distal phalanx in course of differentiation. Interdigital implantation of beads bearing CCN1 induced the upregulation of Tenascin C and the downregulation of CG-8
Title: Defining the earliest transcriptional steps of chondrogenic progenitor specification during the formation of the digits in the embryonic limb.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in signal transduction	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: CCN family member 1

Names: Protein CEF-10; cellular communication network factor 1; protein CYR61

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001031563.2 → NP_001026734.1 CCN family member 1 precursor

See identical proteins and their annotated locations for NP_001026734.1

Status: PROVISIONAL

Source sequence(s)

JAENSK010000239

UniProtKB/Swiss-Prot

P19336

UniProtKB/TrEMBL

A0A8V0ZE58

Related

ENSGALP00010029502.1, ENSGALT00010049947.1

Conserved Domains (4) summary

smart00209
Location:227 → 267

TSP1; Thrombospondin type 1 repeats

smart00214
Location:100 → 159

VWC; von Willebrand factor (vWF) type C domain

pfam00007
Location:288 → 371

Cys_knot; Cystine-knot domain

pfam00219
Location:26 → 78

IGFBP; Insulin-like growth factor binding protein

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052539.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

15923041..15925475 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052580.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

15931668..15934101 complement

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GenBank, FASTA, Sequence Viewer (Graphics)