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EOMES eomesodermin [ Gallus gallus (chicken) ]

Gene ID: 428443, updated on 17-Aug-2024

Summary

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Symbol
EOMESprovided by CGNC
Full Name
eomesoderminprovided by CGNC
Primary source
CGNC:66561
See related
Ensembl:ENSGALG00010002605
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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See EOMES in Genome Data Viewer
Location:
chromosome: 2
Exon count:
6
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 2 NC_052533.1 (38502625..38507358, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 2 NC_052574.1 (38553599..38558344, complement)

Chromosome 2 - NC_052533.1Genomic Context describing neighboring genes Neighboring gene NIMA related kinase 10 Neighboring gene solute carrier family 4 member 7 Neighboring gene uncharacterized LOC121113110 Neighboring gene uncharacterized LOC121113109

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A genomic duplication is associated with ectopic eomesodermin expression in the embryonic chicken comb and two duplex-comb phenotypes. Dorshorst B, et al. PLoS Genet, 2015 Mar. PMID 25789773, Free PMC Article
  2. Comparison of extraembryonic expression of Eomes and Cdx2 in pregastrulation chick and mouse embryo unveils regulatory changes along evolution. Pernaute B, et al. Dev Dyn, 2010 Feb. PMID 20014105
  3. Splenic gene expression profiling in White Leghorn layer inoculated with the Salmonella enterica serovar Enteritidis. Wu G, et al. Anim Genet, 2015 Dec. PMID 26358731
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This suggests that the 20 Kb duplication contains regulatory elements affecting EOMES expression. These findings complete our characterization of the genetic basis of the three major comb loci in the chicken
    Title: A genomic duplication is associated with ectopic eomesodermin expression in the embryonic chicken comb and two duplex-comb phenotypes.
  2. expressed in extraembryonic tissues, but temporal pattern of expression differs from what occurs in mouse
    Title: Comparison of extraembryonic expression of Eomes and Cdx2 in pregastrulation chick and mouse embryo unveils regulatory changes along evolution.
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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in CD8-positive, alpha-beta T cell differentiation involved in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in endodermal cell fate specification IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in mesoderm formation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
eomesodermin homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321555.2 → NP_001308484.1  eomesodermin homolog

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000037
    UniProtKB/TrEMBL
    R4GH67
    Related
    ENSGALP00010003753.1, ENSGALT00010006022.1
    Conserved Domains (2) summary
    cd00182
    Location:224 → 417
    TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
    pfam16176
    Location:439 → 659
    T-box_assoc; T-box transcription factor-associated

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    38502625..38507358 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_426003.7 → XP_426003.3  eomesodermin homolog isoform X1

    Conserved Domains (2) summary
    cd00182
    Location:224 → 417
    TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
    pfam16176
    Location:420 → 640
    T-box_assoc; T-box transcription factor-associated

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052574.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    38553599..38558344 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046911695.1 → XP_046767651.1  eomesodermin homolog isoform X1

Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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Molecular Biology Databases
Research Materials