GAP43 growth associated protein 43 [Gallus gallus (chicken)] - Gene

Summary

Symbol: GAP43provided by CGNC
Full Name: growth associated protein 43provided by CGNC
Primary source: CGNC:11226
See related: Ensembl:ENSGALG00010006492
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: GAP-43
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	1	NC_052532.1 (82287310..82345932, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	1	NC_052573.1 (82473255..82531915, complement)

Chromosome 1 - NC_052532.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GAP-43 protein is expressed in the rostral brain neurons of early chick embryos
Title: Differential expression of GAP-43 protein in the rostral brain neurons of early chick embryos.
permanently dephosphorylated GAP-43 may disrupt normal axonal fasciculation which gives rise to the ectopic growth into distal stratum oriens
Title: Ectopic growth of hippocampal mossy fibers in a mutated GAP-43 transgenic mouse with impaired spatial memory retention.
first evidence that links increased GAP-43 expression with growth of central axons; findings raise questions about the properties of granule cells and the mossy fiber mechanisms that differentially regulate axonal remodeling in the adult hippocampus
Title: Overexpression of GAP-43 reveals unexpected properties of hippocampal mossy fibers.
GAP-43 expression in the adult and developing oscine song control system.
Title: Conservation and expression of IQ-domain-containing calpacitin gene products (neuromodulin/GAP-43, neurogranin/RC3) in the adult and developing oscine song control system.
role of GAP-43 protein levels in regulating memory function
Title: GAP-43 gene expression regulates information storage.

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General gene information

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Markers

GDB:181207 (e-PCR)
- UniSTS:155175

GAP43 (e-PCR)
- UniSTS:479844

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables calmodulin binding	IEA Inferred from Electronic Annotation more info	PubMed
enables lysophosphatidic acid binding	IEA Inferred from Electronic Annotation more info	PubMed
enables phosphatidylinositol phosphate binding	IEA Inferred from Electronic Annotation more info	PubMed
enables phosphatidylserine binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in axon choice point recognition	IEA Inferred from Electronic Annotation more info	PubMed
involved_in axon regeneration	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of growth	IEA Inferred from Electronic Annotation more info	PubMed
involved_in tissue regeneration	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: neuromodulin

Names: axonal membrane protein GAP-43

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001305054.2 → NP_001291983.2 neuromodulin

Status: VALIDATED

Source sequence(s)

JAENSK010000017

UniProtKB/Swiss-Prot

P35001

Related

ENSGALP00010009014.1, ENSGALT00010015437.1

Conserved Domains (2) summary

smart00015
Location:31 → 53

IQ; Calmodulin-binding motif

pfam06614
Location:69 → 246

Neuromodulin

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

82287310..82345932 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

82473255..82531915 complement

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GenBank, FASTA, Sequence Viewer (Graphics)