SLC30A5 solute carrier family 30 member 5 [Gallus gallus (chicken)] - Gene

Summary

Symbol: SLC30A5provided by CGNC
Full Name: solute carrier family 30 member 5provided by CGNC
Primary source: CGNC:10966
See related: Ensembl:ENSGALG00010010751
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: ZnT5
Orthologs: human mouse all
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Genomic context

Location:: chromosome: Z

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	Z	NC_052572.1 (22425459..22445960)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	Z	NC_059536.1 (22425459..22445960)

Chromosome Z - NC_052572.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ZnT5(-)ZnT7(-/-) cells showed exacerbation of the unfolded protein response as did the wild-type cells cultured under a zinc-deficient condition, revealing that both complexes play a role in homeostatic maintenance of secretory pathway function
Title: Zinc transport complexes contribute to the homeostatic maintenance of secretory pathway function in vertebrate cells.
contributes to the conversion of apo-alkaline phosphatase to holo-alkaline phosphatase
Title: Zinc transporters, ZnT5 and ZnT7, are required for the activation of alkaline phosphatases, zinc-requiring enzymes that are glycosylphosphatidylinositol-anchored to the cytoplasmic membrane.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables zinc ion transmembrane transporter activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in intracellular zinc ion homeostasis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info	PubMed
involved_in zinc ion transport	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: proton-coupled zinc antiporter SLC30A5; zinc transporter 5

Names: solute carrier family 30 (zinc transporter), member 5; znT-5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001031419.3 → NP_001026590.2 proton-coupled zinc antiporter SLC30A5

See identical proteins and their annotated locations for NP_001026590.2

Status: PROVISIONAL

Source sequence(s)

JAENSK010000089

UniProtKB/Swiss-Prot

Q5MNV7, Q5ZLF4

UniProtKB/TrEMBL

A0A8V0Y696

Related

ENSGALP00010014482.1, ENSGALT00010025697.1

Conserved Domains (2) summary

COG1230
Location:412 → 734

CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]

pfam01545
Location:425 → 654

Cation_efflux; Cation efflux family

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052572.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

22425459..22445960

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_025144707.3 → XP_025000475.1 zinc transporter 5 isoform X1

UniProtKB/TrEMBL

A0A8V0Y1M8

Conserved Domains (1) summary

COG1230
Location:342 → 664

CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]