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ZP2 zona pellucida glycoprotein 2 [ Gallus gallus (chicken) ]

Gene ID: 427006, updated on 10-Oct-2024

Summary

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Symbol
ZP2provided by CGNC
Full Name
zona pellucida glycoprotein 2provided by CGNC
Primary source
CGNC:1731
See related
Ensembl:ENSGALG00010017068
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
ZPA
Orthologs
human mouse all
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Genomic context

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See ZP2 in Genome Data Viewer
Location:
chromosome: 14
Exon count:
21
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 14 NC_052545.1 (15145549..15153351, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 14 NC_052586.1 (14477770..14485551)

Chromosome 14 - NC_052545.1Genomic Context describing neighboring genes Neighboring gene dynein axonemal heavy chain 3 Neighboring gene transmembrane protein 159 Neighboring gene ankyrin repeat and sterile alpha motif domain containing 4B Neighboring gene crystallin mu Neighboring gene ubiquinol-cytochrome c reductase core protein II

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Glycosylated chicken ZP2 accumulates in the egg coat of immature oocytes and remains localized to the germinal disc region of mature eggs. Nishio S, et al. Biol Reprod, 2014 Nov. PMID 25253730
  2. Isolation and mapping the chicken zona pellucida genes: an insight into the evolution of orthologous genes in different species. Smith J, et al. Mol Reprod Dev, 2005 Feb. PMID 15570621
  3. An expressed sequence tag analysis of the chicken reproductive tract transcriptome. Froman DP, et al. Poult Sci, 2006 Aug. PMID 16903475
  4. A comprehensive collection of chicken cDNAs. Boardman PE, et al. Curr Biol, 2002 Nov 19. PMID 12445392
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A role for ZP2 in the preferential binding and penetration of sperm in the germinal disc region of bird eggs.
    Title: Glycosylated chicken ZP2 accumulates in the egg coat of immature oocytes and remains localized to the germinal disc region of mature eggs.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables acrosin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables structural constituent of egg coat IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in binding of sperm to zona pellucida IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in prevention of polyspermy IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in egg coat IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
zona pellucida sperm-binding protein 2
Names
zona pellucida A
zona pellucida glycoprotein 2 (sperm receptor)
zona pellucida protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001397405.1 → NP_001384334.1  zona pellucida sperm-binding protein 2

    Status: VALIDATED

    Source sequence(s)
    AB197938, BU472281, BX266771, BX268842, DT655971, DT658349, HAEK01066119, HAEK01134372, JAENSK010000258
    UniProtKB/TrEMBL
    A0A8V0YZB7, A0A8V0Z133
    Related
    ENSGALP00010024142.1, ENSGALT00010041243.1

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052545.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    15145549..15153351 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_015294817.4 → XP_015150303.2  zona pellucida sperm-binding protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A8V0Z133
    Related
    ENSGALP00010024133.1, ENSGALT00010041226.1
    Conserved Domains (1) summary
    smart00241
    Location:349 → 614
    ZP; Zona pellucida (ZP) domain

  2. XM_015294816.3 → XP_015150302.2  zona pellucida sperm-binding protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8V0YZB1, A0A8V0Z133
    Related
    ENSGALP00010024137.1, ENSGALT00010041234.1
    Conserved Domains (1) summary
    smart00241
    Location:498 → 763
    ZP; Zona pellucida (ZP) domain

  3. XM_040647428.2 → XP_040503362.1  zona pellucida sperm-binding protein 2 isoform X2

    Conserved Domains (1) summary
    cl27758
    Location:498 → 642
    Zona_pellucida; Zona pellucida-like domain

  4. XM_040647430.2 → XP_040503364.1  zona pellucida sperm-binding protein 2 isoform X4

    Conserved Domains (1) summary
    cl27758
    Location:498 → 629
    Zona_pellucida; Zona pellucida-like domain

RNA

  1. XR_005839736.2 RNA Sequence

  2. XR_006931465.1 RNA Sequence

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052586.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    14477770..14485551
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046927529.1 → XP_046783485.1  zona pellucida sperm-binding protein 2 isoform X1

  2. XM_046927531.1 → XP_046783487.1  zona pellucida sperm-binding protein 2 isoform X3

  3. XM_046927530.1 → XP_046783486.1  zona pellucida sperm-binding protein 2 isoform X2

  4. XM_046927533.1 → XP_046783489.1  zona pellucida sperm-binding protein 2 isoform X4

  5. XM_046927532.1 → XP_046783488.1  zona pellucida sperm-binding protein 2 isoform X5

RNA

  1. XR_006936201.1 RNA Sequence

  2. XR_006936202.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001039098.1: Suppressed sequence

    Description
    NM_001039098.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version

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